Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery

First Posted Date
2019-11-25
Last Posted Date
2024-11-12
Lead Sponsor
Case Comprehensive Cancer Center
Target Recruit Count
30
Registration Number
NCT04176419
Locations
🇺🇸

Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

KEYMAKER-U01 Substudy 3: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Participants With Advanced Non-small Cell Lung Cancer (NSCLC), Previously Treated With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Therapy (MK-3475-01C/KEYMAKER-U01C)

First Posted Date
2019-11-15
Last Posted Date
2024-12-12
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
135
Registration Number
NCT04165096
Locations
🇺🇸

Cleveland Clinic Main ( Site 0006), Cleveland, Ohio, United States

🇺🇸

Banner MD Anderson Cancer Center ( Site 0001), Gilbert, Arizona, United States

🇺🇸

City of Hope ( Site 0014), Duarte, California, United States

and more 36 locations

Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty

First Posted Date
2019-10-11
Last Posted Date
2023-06-01
Lead Sponsor
Naestved Hospital
Target Recruit Count
1060
Registration Number
NCT04123873
Locations
🇩🇰

Køge Hospital, Køge, Denmark

🇩🇰

Næstved-Slagelse-Ringsted Hospitals, Næstved, Danmark, Denmark

🇩🇰

Gentofte Hospital, Hellerup, Denmark

and more 4 locations

Acetaminophen (APAP) +/- Oxycodone

Phase 4
Completed
Conditions
Interventions
First Posted Date
2019-10-10
Last Posted Date
2024-02-28
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
393
Registration Number
NCT04122443
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Research Study to Investigate the Effect of NNC0174-0833 on a Birth Control Pill in Women Who Are Not Able to Become Pregnant

First Posted Date
2019-08-29
Last Posted Date
2022-01-10
Lead Sponsor
Novo Nordisk A/S
Target Recruit Count
31
Registration Number
NCT04074174
Locations
🇨🇦

Novo Nordisk Investigational Site, Montreal, Quebec, Canada

Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion Surgery

First Posted Date
2019-08-02
Last Posted Date
2021-06-18
Lead Sponsor
Peking University Third Hospital
Target Recruit Count
183
Registration Number
NCT04042948
Locations
🇨🇳

Peking University Third Hospital, Beijing, Haidian, China

Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus Arteriosus

First Posted Date
2019-07-30
Last Posted Date
2019-07-30
Lead Sponsor
Máximo Vento Torres
Target Recruit Count
300
Registration Number
NCT04037514
Locations
🇪🇸

Hospital Reina Sofía, Córdoba, Cordoba, Spain

🇪🇸

Hospital Universitario de Cabueñes, Gijón, Spain

🇪🇸

Hospital Universitari i Politècnic La Fe, Valencia, Spain

and more 1 locations

Pre-emptive Paracetamol for Prevention of Intraoperative Shoulder Tip Pain

First Posted Date
2019-07-30
Last Posted Date
2020-01-27
Lead Sponsor
Cairo University
Target Recruit Count
120
Registration Number
NCT04038307
Locations
🇪🇬

Faculty of medicine, Cairo, Egypt

Symptomatic Management of Lyme Arthritis

First Posted Date
2019-07-30
Last Posted Date
2023-12-05
Lead Sponsor
Desiree Neville, MD
Target Recruit Count
300
Registration Number
NCT04038346
Locations
🇺🇸

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States

Measuring Blood Flow in the Brain After Epileptic Activity

First Posted Date
2019-07-22
Last Posted Date
2023-11-18
Lead Sponsor
Rijnstate Hospital
Target Recruit Count
34
Registration Number
NCT04028596
Locations
🇳🇱

Rijnstate Hospital, Arnhem, Gelderland, Netherlands

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