Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

First Posted Date
2020-02-17
Last Posted Date
2024-10-31
Lead Sponsor
Sanofi
Target Recruit Count
337
Registration Number
NCT04270409
Locations
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Investigational Site Number :0360008, Liverpool, New South Wales, Australia

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Investigational Site Number :3920001, Shibuya-ku, Tokyo, Japan

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Investigational Site Number :4400001, Vilnius, Lithuania

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First Posted Date
2020-02-13
Last Posted Date
2024-06-14
Lead Sponsor
University of Miami
Target Recruit Count
306
Registration Number
NCT04268498
Locations
🇺🇸

University of Miami, Miami, Florida, United States

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MD Anderson Cancer Center, Houston, Texas, United States

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Moffitt Cancer Center, Tampa, Florida, United States

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Effect of Paracetamol on Kidney Function in Severe Malaria

First Posted Date
2020-01-31
Last Posted Date
2023-06-13
Lead Sponsor
University of British Columbia
Target Recruit Count
460
Registration Number
NCT04251351
Locations
🇨🇩

The Kinshasa Medical Oxford Research Unit (KIMORU), Kinshasa, Congo, Congo, The Democratic Republic of the

Multimodal Pain Study in Free Flap Patients

First Posted Date
2020-01-29
Last Posted Date
2023-08-18
Lead Sponsor
University of Kansas Medical Center
Target Recruit Count
30
Registration Number
NCT04246697
Locations
🇺🇸

University of Kansas Medical Center, Kansas City, Kansas, United States

A Study of the Newly Formulated Tylenol Tablet (Acetaminophen) to the Tylenol 8 Hour (H) Extended Release (ER) Tablet (Acetaminophen) in Healthy Participants

Phase 1
Completed
Conditions
Interventions
First Posted Date
2020-01-18
Last Posted Date
2024-03-29
Lead Sponsor
Janssen Korea, Ltd., Korea
Target Recruit Count
30
Registration Number
NCT04230252
Locations
🇰🇷

H plus Yangji Hospital, Seoul, Korea, Republic of

A Study To Evaluate The Efficacy And Safety Of Obinutuzumab In Patients With ISN/RPS 2003 Class III Or IV Lupus Nephritis

First Posted Date
2020-01-09
Last Posted Date
2024-10-15
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
271
Registration Number
NCT04221477
Locations
🇺🇸

North Shore University Hospital, Manhasset, New York, United States

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University of Texas Southwestern, Dallas, Texas, United States

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Universitaetsmedizin Johannes Gutenberg; Rheumatologie, Mainz, Germany

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A Study of Newly Formulated Tylenol Tablet (Acetaminophen) and Tylenol 8 Hour (H) Extended Release (ER) Tablet (Acetaminophen) in Healthy Participants

Phase 1
Completed
Conditions
Interventions
First Posted Date
2020-01-02
Last Posted Date
2023-01-05
Lead Sponsor
Janssen Korea, Ltd., Korea
Target Recruit Count
30
Registration Number
NCT04214691
Locations
🇰🇷

H plus Yangji Hospital, Seoul, Korea, Republic of

Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Success in Patients With Acute Pulpitis

First Posted Date
2019-12-17
Last Posted Date
2021-07-21
Lead Sponsor
Cairo University
Target Recruit Count
69
Registration Number
NCT04202406
Locations
🇪🇬

Faculty of dentistry Cairo university, Giza, Non-US/Non-Canadian, Egypt

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