Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Paracetamol Versus Ibuprofen for PDA Closure

First Posted Date
2017-08-29
Last Posted Date
2017-08-29
Lead Sponsor
Ain Shams University
Target Recruit Count
30
Registration Number
NCT03265782

Regional Analgesia After Cesarean Section

First Posted Date
2017-08-09
Last Posted Date
2020-02-18
Lead Sponsor
Medical University of Lublin
Target Recruit Count
105
Registration Number
NCT03244540
Locations
🇵🇱

Szpital Specjalistyczny PRO-FAMILIA w Rzeszowie, Rzeszów, Poland

🇵🇱

Szpital Kliniczny Dzieciątka Jezus, Warszawa, Poland

Effect of Early Pain Management at Triage on Opioid Consumption

First Posted Date
2017-08-08
Last Posted Date
2017-11-30
Lead Sponsor
University of Monastir
Target Recruit Count
1500
Registration Number
NCT03243006

Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial

First Posted Date
2017-08-07
Last Posted Date
2021-10-29
Lead Sponsor
University of Texas at Austin
Target Recruit Count
102
Registration Number
NCT03241030
Locations
🇺🇸

Dell Children's Medical Center, Austin, Texas, United States

Validation of a Physiological Based Pharmacokinetic Model by the Study of Paracetamol Distribution in the Brain Compartments in Brain Injured Patients

Phase 1
Completed
Conditions
Interventions
First Posted Date
2017-07-21
Last Posted Date
2019-02-18
Lead Sponsor
Poitiers University Hospital
Target Recruit Count
17
Registration Number
NCT03223506
Locations
🇫🇷

CHU de Poitiers, Poitiers, France

NSAIDs Versus Paracetamol Versus Paracetamol + NSAIDs in Traumatic Pain Management

First Posted Date
2017-07-19
Last Posted Date
2020-09-30
Lead Sponsor
University of Monastir
Target Recruit Count
1500
Registration Number
NCT03222518
Locations
🇹🇳

Monastir University Hospital, Monastir, Tunisia

Acetaminophen Dosing in Obese Adolescents

Phase 3
Suspended
Conditions
Interventions
First Posted Date
2017-06-20
Last Posted Date
2024-08-22
Lead Sponsor
Children's National Research Institute
Target Recruit Count
6
Registration Number
NCT03192566
Locations
🇺🇸

Childrens National Health System, Washington, District of Columbia, United States

Ibuprofen, Paracetamol Versus Placebo on Pain During Local Anesthetic Injection (RCT)

First Posted Date
2017-06-12
Last Posted Date
2017-06-14
Lead Sponsor
Cairo University
Target Recruit Count
52
Registration Number
NCT03184649
Locations
🇪🇬

Faculty of Dentistry, Cairo, Egypt

Variability of Sulfotransferase 1A1 Activity in Humans: an Approach to Improve Predictive Drug Response - Part I: Analysis of Intraindividual Variation in Healthy Adults

Phase 1
Completed
Conditions
Interventions
First Posted Date
2017-06-09
Last Posted Date
2021-08-25
Lead Sponsor
Hospital da Luz, Portugal
Target Recruit Count
36
Registration Number
NCT03182595
Locations
🇵🇹

Hospital da Luz, Lisboa, Portugal

© Copyright 2024. All Rights Reserved by MedPath