Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Pharmacokinetics of Paracetamol and Antiepileptic Drugs After Sleeve Gastrectomy

First Posted Date
2017-05-19
Last Posted Date
2021-09-24
Lead Sponsor
Rambam Health Care Campus
Target Recruit Count
2
Registration Number
NCT03161509
Locations
🇮🇱

Rambam Healthcare Campus, Haifa, Israel

Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine in Emergency Department

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-05-09
Last Posted Date
2017-05-09
Lead Sponsor
Pamukkale University
Target Recruit Count
200
Registration Number
NCT03145467
Locations
🇹🇷

Pamukkale University, Denizli, Turkey

Preoperative Acetaminophen and Carbohydrate Loading

Phase 3
Completed
Conditions
Interventions
First Posted Date
2017-04-27
Last Posted Date
2019-10-07
Lead Sponsor
Tufts Medical Center
Target Recruit Count
101
Registration Number
NCT03131713
Locations
🇺🇸

Tufts Dermatology, Boston, Massachusetts, United States

Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery

First Posted Date
2017-04-25
Last Posted Date
2017-09-05
Lead Sponsor
Western University, Canada
Target Recruit Count
100
Registration Number
NCT03128346
Locations
🇨🇦

London Health Sciences Centre, London, Ontario, Canada

Postoperative Effects of TAP Block Versus QLB Type 2 Block

First Posted Date
2017-04-24
Last Posted Date
2017-11-14
Lead Sponsor
Bozyaka Training and Research Hospital
Target Recruit Count
90
Registration Number
NCT03126084
Locations
🇹🇷

Izmir Bozyaka Training and Research Hospital, Izmir, Turkey

Pain Management in Head and Neck Surgery Patients

First Posted Date
2017-04-20
Last Posted Date
2021-06-22
Lead Sponsor
University of Alabama at Birmingham
Registration Number
NCT03121963

Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Nontraumatic Musculoskeletal Pain

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-04-20
Last Posted Date
2017-04-21
Lead Sponsor
Pamukkale University
Target Recruit Count
200
Registration Number
NCT03122314
Locations
🇹🇷

Pamukkale University, Denizli, Turkey

Acetaminophen IV vs Hydromorphone IV in the ED

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-04-11
Last Posted Date
2017-11-17
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
220
Registration Number
NCT03107481
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction

First Posted Date
2017-04-10
Last Posted Date
2022-08-03
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
100
Registration Number
NCT03105518
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

The Effectiveness of IV/PO Acetaminophen in the Perioperative Period in Reducing Opiate Use After Lumbar Spine Fusion

First Posted Date
2017-04-07
Last Posted Date
2019-10-08
Lead Sponsor
University of Southern California
Target Recruit Count
28
Registration Number
NCT03104816
Locations
🇺🇸

Keck Hospital of USC, Los Angeles, California, United States

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