Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
- -
Effectiveness and Safety of Breeded Leech for Symptomatic Primary Arthrosis of the First Carpometacarpal Joint
- First Posted Date
- 2017-01-13
- Last Posted Date
- 2019-02-12
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 52
- Registration Number
- NCT03020368
- Locations
- 🇩🇪
Hochschulambulanz für Naturheilkunde der Charité-Universitätsmedizin Berlin am Immanuel-Krankenhaus, Berlin, Germany
Evaluating Acupuncture Relationship With the Catecholaminergic Pathway
- Conditions
- Interventions
- First Posted Date
- 2016-08-23
- Last Posted Date
- 2018-08-01
- Lead Sponsor
- Universidad Autónoma Benito Juárez de Oaxaca
- Target Recruit Count
- 30
- Registration Number
- NCT02876432
CYP4A11 and CYP4F2 Gene Variants as Makers of Cardiovascular Adverse Events of Non-steroidal Anti-inflammatory Drugs
- Conditions
- Interventions
- First Posted Date
- 2016-05-20
- Last Posted Date
- 2016-05-20
- Lead Sponsor
- Eduardo Barbosa Coelho
- Target Recruit Count
- 20
- Registration Number
- NCT02779530
- Locations
- 🇧🇷
Unidade de Pesquisa Clínica HCRP-USP, Ribeirao Preto, Sao Paulo, Brazil
Oral Tramadol Versus Diclofenac For Pain Relief Before Outpatient Hysteroscopy:
- First Posted Date
- 2016-05-04
- Last Posted Date
- 2016-05-04
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 102
- Registration Number
- NCT02760888
- Locations
- 🇪🇬
Ain Shams University, Cairo, Egypt
Delayed Release Diclofenac Sodium Formulation vs Voltaren®
- Conditions
- Interventions
- First Posted Date
- 2016-03-22
- Last Posted Date
- 2016-09-28
- Lead Sponsor
- BDD Pharma Ltd
- Target Recruit Count
- 36
- Registration Number
- NCT02714842
- Locations
- 🇬🇧
Bio Images Research Ltd, Glasgow, United Kingdom
Oral Hyoscine Butyl Bromide Versus Diclofenac Potassium Before Office Hysteroscopy
- Conditions
- Interventions
- First Posted Date
- 2016-03-21
- Last Posted Date
- 2018-01-05
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 129
- Registration Number
- NCT02714699
- Locations
- 🇪🇬
Ahmed Abbas, Assiut, Cairo, Egypt
Capsaicin + Diclofenac Gel in Acute Back Pain or Neck Pain
- First Posted Date
- 2016-03-07
- Last Posted Date
- 2019-05-06
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 746
- Registration Number
- NCT02700815
- Locations
- 🇩🇪
Anästhesiologie Rheinbach, Rheinbach, Germany
🇩🇪Praxis Dr. Schaefer, 45355 Essen, Essen, Germany
🇩🇪Dünnwaldpraxis, Köln, Köln, Germany
Comparison of the Use of Dexamethasone and Diclofenac Sodium in Immediate Post-Operative Care in Third Molar Surgery
- Conditions
- Interventions
- First Posted Date
- 2016-03-03
- Last Posted Date
- 2016-03-03
- Lead Sponsor
- Hospital Geral de Vila Penteado
- Target Recruit Count
- 30
- Registration Number
- NCT02698306
- Locations
- 🇧🇷
Hospital Geral de Vila Penteado, São Paulo, Brazil
Delirium in Elderly Patients With Trauma of the Hip
- First Posted Date
- 2016-02-23
- Last Posted Date
- 2023-08-04
- Target Recruit Count
- 239
- Registration Number
- NCT02689024
- Locations
- 🇳🇱
Meander Medical Center, Amersfoort, Netherlands
🇳🇱VU Medical Center, Amsterdam, Netherlands
🇳🇱Academic Medical Center, Amsterdam, Netherlands
Assess the Efficacy and Safety in Volunteers of DCF100, TIB200 and SPR300 vs. Placebo and Control(s) in a UV Pain Model
- Conditions
- Interventions
- First Posted Date
- 2016-01-28
- Last Posted Date
- 2021-01-27
- Lead Sponsor
- Futura Medical Developments Ltd.
- Target Recruit Count
- 60
- Registration Number
- NCT02666846
- Locations
- 🇬🇧
PAREXEL EPCU Northwick Park, Harrow, Middlesex, United Kingdom
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.