Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
- -
Diclofenac for the Treatment of Patients with Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy
- Conditions
- Interventions
- First Posted Date
- 2024-12-12
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- Emory University
- Target Recruit Count
- 20
- Registration Number
- NCT06731270
- Locations
- 🇺🇸
Emory University Hospital Midtown, Atlanta, Georgia, United States
🇺🇸Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States
Topical Treatments for Ankle Sprains
- First Posted Date
- 2024-10-02
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- Ankara City Hospital Bilkent
- Target Recruit Count
- 100
- Registration Number
- NCT06623929
- Locations
- 🇹🇷
Ankara Etlik City Hospital, Ankara, Turkey
KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism
- Conditions
- Interventions
- First Posted Date
- 2024-08-22
- Last Posted Date
- 2024-08-22
- Lead Sponsor
- Helsinki University Central Hospital
- Target Recruit Count
- 12
- Registration Number
- NCT06566794
- Locations
- 🇫🇮
Department of Clinical Pharmacology, Helsinki, Finland
Evaluation of the Effect of Intra-ligamentary Injection of Diclofenac Potassium Versus Articaine on Anaesthetic Efficacy in Mandibular Molars With Symptomatic Irreversible Pulpitis.
- Conditions
- Interventions
- First Posted Date
- 2024-07-15
- Last Posted Date
- 2024-08-06
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 40
- Registration Number
- NCT06500871
NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow
- Conditions
- Interventions
- First Posted Date
- 2024-04-18
- Last Posted Date
- 2024-08-22
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 92
- Registration Number
- NCT06373978
- Locations
- 🇺🇸
The Cleveland Clinic Florida, Coral Springs, Florida, United States
🇺🇸The Cleveland Clinic Ohio, Avon, Ohio, United States
The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain
- Conditions
- Interventions
- First Posted Date
- 2024-03-07
- Last Posted Date
- 2024-03-07
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 120
- Registration Number
- NCT06298383
Comparative Analysis of Radiotherapeutic and Medical Procedures for the Prophylaxis of Heterotopic Ossifications
- Conditions
- Interventions
- First Posted Date
- 2024-02-09
- Last Posted Date
- 2024-02-09
- Lead Sponsor
- University of Jena
- Target Recruit Count
- 512
- Registration Number
- NCT06251349
- Locations
- 🇩🇪
Department of Radiooncology, Jena, Jena, Germany
Efficacy of Single Dose Rectal Diclofenac With Oral Diclofenac for the Relief of Perineal Pain Within 24 Hours After Episiotomy
- First Posted Date
- 2024-01-23
- Last Posted Date
- 2024-01-23
- Lead Sponsor
- Federal Teaching Hospital Abakaliki
- Target Recruit Count
- 146
- Registration Number
- NCT06220279
- Locations
- 🇳🇬
Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi, Nigeria
🇳🇬Federal Teaching Hospital, Abakaliki, Abakaliki, Ebonyi, Nigeria
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
- Conditions
- Interventions
- First Posted Date
- 2024-01-16
- Last Posted Date
- 2024-01-17
- Lead Sponsor
- British University In Egypt
- Target Recruit Count
- 48
- Registration Number
- NCT06207253
- Locations
- 🇪🇬
British university in Egypt, Cairo, Egypt
Comparative Evaluation of the Effectiveness of Diclofenac Sodium Versus Vitamin D on Myofascial Pain
- Conditions
- Interventions
- First Posted Date
- 2023-11-01
- Last Posted Date
- 2023-11-03
- Lead Sponsor
- Yuzuncu Yıl University
- Target Recruit Count
- 40
- Registration Number
- NCT06111573
- Locations
- 🇹🇷
Van Yüzüncü Yıl University, Van, Turkey
Drug Development Updates
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