Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
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Penile Fracture: A Comparison of Erectile Function After Immediate Repair Versus Delayed Repair
- Conditions
- Interventions
- First Posted Date
- 2018-02-28
- Last Posted Date
- 2018-03-01
- Lead Sponsor
- Ministry of Health, Jamaica
- Target Recruit Count
- 46
- Registration Number
- NCT03449940
- Locations
- 🇯🇲
Kingston Public Hospital, Kingston, Jamaica
🇯🇲University Hospital of the West Indies, Kingston, Jamaica
Lidocaine Infusion On Hysteroscopic Media Versus Oral Diclofinac For Pain Relief During Outpatient Hysteroscopy
- First Posted Date
- 2017-10-02
- Last Posted Date
- 2017-10-02
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 44
- Registration Number
- NCT03298646
- Locations
- 🇪🇬
Ain Shams maternity hospital, Cairo, Egypt
A Comparative Evaluation of Diclofenac Sodium Transdermal Patch, Oral Diclofenac Sodium With Intramuscular Injections of Diclofenac Sodium in Patients Suffering From Oral Pain
- First Posted Date
- 2017-07-19
- Last Posted Date
- 2017-12-19
- Target Recruit Count
- 90
- Registration Number
- NCT03221946
- Locations
- 🇮🇳
Panineeya Institute of Dental Sciences, Hyderabad, Telangana, India
Treatment of Renal Colic in the Emergency Departement (ED).
- Conditions
- Interventions
- First Posted Date
- 2017-06-27
- Last Posted Date
- 2022-08-10
- Lead Sponsor
- University of Monastir
- Target Recruit Count
- 600
- Registration Number
- NCT03199924
- Locations
- 🇹🇳
Emergency department of university hospital Fattouma Bourguiba of Monastir Monastir, Monastir Tunisia, Monastir, Tunisia
Comparative Study Between the Effect of Diclofanic and Ketorolac in Post Tonsillectomy Pain Management
- First Posted Date
- 2017-06-07
- Last Posted Date
- 2020-07-14
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 100
- Registration Number
- NCT03178539
- Locations
- 🇪🇬
Assiut university hospital, Assiut, Asyut Governorate, Egypt
Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis
- First Posted Date
- 2017-05-23
- Last Posted Date
- 2017-05-23
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 68
- Registration Number
- NCT03163420
- Locations
- 🇪🇬
Faculty of Oral and dental medicine, Cairo University, Cairo, Egypt
Use of Topical Liquid Diclofenac Following Laser Microporation of Cutaneous Neurofibromas in Patients With NF1
- Conditions
- Interventions
- First Posted Date
- 2017-03-27
- Last Posted Date
- 2017-10-26
- Lead Sponsor
- Fundação Educacional Serra dos Órgãos
- Target Recruit Count
- 7
- Registration Number
- NCT03090971
- Locations
- 🇧🇷
Fundação Educacional Serra dos Órgãos - UNIFESO, Teresópolis, RJ, Brazil
Comparison of the Bioavailability of Diclofenac in a Combination Product (Diclofenac 2% + Capsaicin 0.075% Topical Gel) With Two Diclofenac Only Products, Diclofenac Mono Gel 2% and Voltarol® 12 Hour Emulgel 2.32% Gel, in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2017-03-08
- Last Posted Date
- 2019-03-01
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 48
- Registration Number
- NCT03074162
- Locations
- 🇿🇦
Bloemfontein Early Phase Clinical Unit, PAREXEL International (South Africa), Bloemfontein, South Africa
Phase 1 Study of the Effects of Combining Topical FDA-approved Drugs on Age-related Pathways on the Skin of Healthy Volunteers
- First Posted Date
- 2017-03-07
- Last Posted Date
- 2019-04-01
- Lead Sponsor
- Anne Chang
- Target Recruit Count
- 10
- Registration Number
- NCT03072485
- Locations
- 🇺🇸
Stanford Dermatology, Redwood City, California, United States
Postoperative Cesarean Delivery Pain Relief; Diclofenac Versus Bupivacaine
- First Posted Date
- 2017-02-01
- Last Posted Date
- 2020-10-22
- Lead Sponsor
- Rajavithi Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT03039426
- Locations
- 🇹🇭
Natthida Mekwongtrakarn, Bangkok, Thailand
🇹🇭Rajavithi Hospital, Bangkok, Thailand
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.