Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
- -
Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery
- First Posted Date
- 2016-01-20
- Last Posted Date
- 2016-01-20
- Lead Sponsor
- Bagcilar Training and Research Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT02658721
A Randomized, Double-Blind, Parallel-Group, Vehicle-Controlled, Multicenter Study Comparing Diclofenac Sodium Gel, 3% to Solaraze® Gel, 3% in the Treatment of Actinic Keratosis on the Face or Bald Scalp
- First Posted Date
- 2015-11-23
- Last Posted Date
- 2017-05-05
- Lead Sponsor
- Teva Pharmaceuticals USA
- Target Recruit Count
- 492
- Registration Number
- NCT02611804
- Locations
- 🇺🇸
Tampa Bay Medical Research, Clearwater, Florida, United States
🇺🇸Greenville Dermatology, Greenville, South Carolina, United States
🇺🇸Clinical Science Institute, Santa Monica, California, United States
Efficacy of Preprocedural Diclofenac in Males Undergoing Double J Stent Removal Under Local Anesthesia
- First Posted Date
- 2015-11-05
- Last Posted Date
- 2018-08-28
- Lead Sponsor
- Institute of Nephro Urology, Bangalore
- Target Recruit Count
- 150
- Registration Number
- NCT02598102
- Locations
- 🇮🇳
Institute of Nephro Urology, Bangalore, Karnataka, India
A Study Investigating Pain Following Single-port or Multi-port Video Assisted Thoracoscopic Surgery
Effectiveness of Diclofenac and Its Association to Codeine After Lower Third Molar Extraction.
- Conditions
- Interventions
- First Posted Date
- 2015-09-11
- Last Posted Date
- 2015-09-11
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 50
- Registration Number
- NCT02547896
Safety and Efficacy of Neuromultivit in Treatment of Vertebrogenic Radiculopathy
- Conditions
- Interventions
- First Posted Date
- 2015-07-27
- Last Posted Date
- 2017-05-09
- Lead Sponsor
- Bausch Health Americas, Inc.
- Target Recruit Count
- 100
- Registration Number
- NCT02508805
- Locations
- 🇷🇺
State Autonomous Institution Republican Clinical Centre of Neurology, Kazan, Republic of Tatarstan, Russian Federation
Comparison of Diclofenac vs. Nepafenac Ophthalmic Drops: Patient Comfort
- Conditions
- Interventions
- First Posted Date
- 2015-07-23
- Last Posted Date
- 2015-07-24
- Lead Sponsor
- Wolfson Medical Center
- Target Recruit Count
- 30
- Registration Number
- NCT02506348
- Locations
- 🇮🇱
The E.Wolfson Medical Center, Holon, Israel
Drug Interaction Study of Safinamide and a BCRP Substrate, Diclofenac, Concomitantly Administered to Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2015-07-13
- Last Posted Date
- 2016-04-15
- Lead Sponsor
- Zambon SpA
- Target Recruit Count
- 24
- Registration Number
- NCT02495831
- Locations
- 🇨🇭
Cross Research SA, Phase I Unit, Arzo, Ticino, Switzerland
A Study to Assess the Efficacy and Tolerability of Diclofenac Potassium Soft Gelatin Capsules Compared With Ibuprofen Tablets in Patients With Moderate to Severe Postoperative Dental Pain
- Conditions
- Interventions
- First Posted Date
- 2015-06-19
- Last Posted Date
- 2016-10-17
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 328
- Registration Number
- NCT02476422
- Locations
- 🇺🇸
Novartis Investigative Site, Austin, Texas, United States
Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder Pain
- First Posted Date
- 2015-05-15
- Last Posted Date
- 2017-03-09
- Lead Sponsor
- University of Debrecen
- Target Recruit Count
- 3
- Registration Number
- NCT02445599
- Locations
- 🇭🇺
UNIVERSITY OF DEBRECEN FACULTY OF MEDICINE Department of Anesthesiology and Intensive Care, Debrecen, Hajdú-Bihar, Hungary
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.