Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
- -
Contribution of UGT2B17 to the Pharmacokinetics of Diclofenac
- Conditions
- Interventions
- First Posted Date
- 2023-09-25
- Last Posted Date
- 2024-11-18
- Lead Sponsor
- Washington State University
- Target Recruit Count
- 30
- Registration Number
- NCT06053411
- Locations
- 🇺🇸
Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, Washington, United States
Diclofenac as a KMO Inhibitor
- First Posted Date
- 2023-09-08
- Last Posted Date
- 2024-11-26
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 12
- Registration Number
- NCT06029296
- Locations
- 🇺🇸
Maryland Psychiatric Research Center (MPRC) Treatment Research Program (TRP), Catonsville, Maryland, United States
Long-term Outcomes of Breast Cancer Patients After Wound Infiltration Analgesia
- First Posted Date
- 2023-04-26
- Last Posted Date
- 2023-04-28
- Lead Sponsor
- Osijek University Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT05829707
COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
- Conditions
- Interventions
- First Posted Date
- 2022-11-23
- Last Posted Date
- 2022-11-23
- Lead Sponsor
- Pakistan Institute of Medical Sciences
- Target Recruit Count
- 120
- Registration Number
- NCT05626140
- Locations
- 🇵🇰
Mehreen Mirza, Rawalpindi, Punjab, Pakistan
Effect of Diclofenac Sodium Versus Calcium Hydroxide as Intracanal Medication on the Intensity of Postoperative Pain, Bacterial Load Reduction and MMP-9 Levels in Patients With Necrotic Pulp.
- Conditions
- Interventions
- First Posted Date
- 2022-10-17
- Last Posted Date
- 2022-11-10
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 30
- Registration Number
- NCT05582421
Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block.
- Conditions
- Interventions
- First Posted Date
- 2022-08-05
- Last Posted Date
- 2022-08-05
- Lead Sponsor
- Farjad Zafar
- Target Recruit Count
- 120
- Registration Number
- NCT05488925
- Locations
- 🇵🇰
Department of Operative Dentistry, Baqai Dental College, Baqai Medical University., Karachi, Sindh, Pakistan
The Incidence of Thoracic Disc Herniation in Patients Presenting With Chronic Upper Back Pain
- Conditions
- First Posted Date
- 2022-04-06
- Last Posted Date
- 2022-08-05
- Lead Sponsor
- Kocaeli University
- Target Recruit Count
- 194
- Registration Number
- NCT05313997
- Locations
- 🇹🇷
Private Medar Hospital, Kocaeli, Turkey
Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures
- Conditions
- Interventions
- First Posted Date
- 2021-11-16
- Last Posted Date
- 2021-11-16
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 100
- Registration Number
- NCT05121233
Tamsulosin as Adjunctive Therapy After Extracorporeal Shock Wave Lithotripsy for Renal Stones
- Conditions
- Interventions
- First Posted Date
- 2021-03-29
- Last Posted Date
- 2021-04-01
- Lead Sponsor
- Hospital Regional de Alta Especialidad del Bajio
- Target Recruit Count
- 60
- Registration Number
- NCT04819828
PROUD Study - Preventing Opioid Use Disorders
- Conditions
- Interventions
- Behavioral: Guided mindfulness exercisesOther: Self-administered aromatherapyDrug: Baby aspirinDrug: Tylenol/AcetaminophenDrug: PregabalinDrug: PrednisoneDrug: MeloxicamDrug: PrilosecDrug: TramadolDrug: VoltarenDrug: ZofranDrug: PepcidDrug: ReglanDrug: VersedDrug: LidocaineDrug: PropofolDrug: AncefDrug: Tranexamic Acid (TXA)Drug: DecadronDrug: Bupivacaine hydrochlorideDrug: Toradol
- First Posted Date
- 2021-02-23
- Last Posted Date
- 2023-06-22
- Lead Sponsor
- Emory University
- Target Recruit Count
- 57
- Registration Number
- NCT04766996
- Locations
- 🇺🇸
Emory University Orthopaedic and Spine Hospital, Atlanta, Georgia, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.