Isosorbide dinitrate

Generic Name: Isosorbide dinitrate

Brand Names: Bidil, Dilatrate, Isordil

Drug Type: Small Molecule

Chemical Formula: C_₆H_₈N_₂O_₈

CAS Number: 87-33-2

Unique Ingredient Identifier: IA7306519N

Background: A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.

Indication: For the prevention of angina pectoris due to coronary artery disease.

Associated Conditions: Angina Pectoris, Heart Failure

Clinical Trials

Intensive Arterial Pressure Control in Acute Coronary Syndrome

Not Applicable

Completed

Conditions: Acute Coronary Syndrome

Interventions: Drug: Isosorbide Dinitrate

First Posted Date: 2014-05-09

Last Posted Date: 2022-08-24

Lead Sponsor: University of Monastir

Target Recruit Count: 1500

Registration Number: NCT02135315

Locations: 🇹🇳
university of Monastir, Monastir, Tunisia

Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure

Phase 3

Conditions: Acute Heart Failure
Left Ventricular Dysfunction

Interventions: Drug: Isosorbide Dinitrate
Drug: Hydralazine

First Posted Date: 2013-04-02

Last Posted Date: 2015-08-14

Lead Sponsor: University of Cape Town

Target Recruit Count: 500

Registration Number: NCT01822808

Locations: 🇿🇦
Hatter Institute for Cardiovascular Research in Africa, Cape Town, Western Cape, South Africa

Vasodilator Therapy for Heart Failure and Preserved Ejection Fraction

Phase 2

Completed

Conditions: Congestive Heart Failure
Heart Failure

Interventions: Drug: Placebo
Drug: Isosorbide Dinitrate + Hydralazine
Drug: Isosorbide Dinitrate

First Posted Date: 2012-01-24

Last Posted Date: 2022-06-21

Lead Sponsor: Corporal Michael J. Crescenz VA Medical Center

Target Recruit Count: 44

Registration Number: NCT01516346

Locations: 🇺🇸
Philadelphia VA Medical Center, Philadelphia, Pennsylvania, United States

A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis

Phase 4

Completed

Conditions: Coronary Artery Stenosis
Coronary Heart Disease

Interventions: Drug: Quick-Acting Heart Reliever
Drug: Isosorbide Dinitrate
Drug: Placebo of Isosorbide Dinitrate
Drug: Placebo of Quick-Acting Heart Reliever
Drug: Aspirin Enteric-coated Tablets

First Posted Date: 2012-01-20

Last Posted Date: 2014-08-05

Lead Sponsor: Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Target Recruit Count: 120

Registration Number: NCT01513070

Locations: 🇨🇳
Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, Beijing, China

To Compare the Pharmacokinetics Profiles of ISO 20, IBU 200 and IBU Plus ISO Combinations 200 + 20

Phase 1

Completed

Conditions: Duchenne Muscular Dystrophy (DMD)

Interventions: Drug: Ibuprofen
Other: Ibuprofen and Isosorbide Dinitrate combination
Drug: Isosorbide Dinitrate

First Posted Date: 2011-11-23

Last Posted Date: 2018-08-31

Lead Sponsor: Parent Project, Italy

Target Recruit Count: 12

Registration Number: NCT01478022

Locations: 🇮🇹
Clinical Phase 1 Unit - Luigi Sacco Hospital, Milan, Italy

Pilot Study of Organic Nitrates on Endothelial Function in CAD Patients

Not Applicable

Conditions: Coronary Artery Disease

Interventions: Drug: PETN, ISDN

First Posted Date: 2009-12-11

Last Posted Date: 2009-12-11

Lead Sponsor: Julius-Maximilians University

Target Recruit Count: 50

Registration Number: NCT01030367

Locations: 🇩🇪
Julius-Maximilians University, Würzburg, Bavaria, Germany

Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure

Phase 4

Completed

Conditions: Anal Fissure

Interventions: Procedure: Botox
Drug: ISDN ointment
Drug: Placebo

First Posted Date: 2009-01-23

Last Posted Date: 2009-01-23

Lead Sponsor: Onze Lieve Vrouwe Gasthuis

Target Recruit Count: 73

Registration Number: NCT00827736

Locations: 🇳🇱
Onze Lieve Vrouwe Gasthuis, Amsterdam, Noord Holland, Netherlands

Treatment of Orthostatic Intolerance

Phase 1

Active, not recruiting

Conditions: Tachycardia
Chronic Orthostatic Intolerance

Interventions: Drug: Entacapone & Propranolol
Drug: Atomoxetine
Drug: Acetazolamide
Dietary Supplement: Melatonin
Other: NO Drug
Drug: Isosorbide Dinitrate
Radiation: Placebo
Device: Breathing Device
Other: Drinking Water
Procedure: IV Saline
Device: Abdominal binder
Drug: Indomethacin
Drug: Midodrine
Drug: Mecamylamine
Drug: Clonidine
Drug: Entacapone
Drug: memantine
Drug: Modafinil
Drug: Octreotide
Drug: Sertraline
Drug: Atomoxetine & Propranolol
Drug: Modafinil & Propranolol
Drug: Propranolol

First Posted Date: 2005-12-06

Last Posted Date: 2024-10-02

Lead Sponsor: Satish R. Raj

Target Recruit Count: 150

Registration Number: NCT00262470

Locations: 🇺🇸
Vanderbilt University Autonomic Dysfunction Center, Nashville, Tennessee, United States

Asymptomatic Cardiac Ischemia Pilot (ACIP) Study

Phase 3

Completed

Conditions: Cardiovascular Diseases
Coronary Disease
Myocardial Ischemia
Heart Diseases

First Posted Date: 1999-10-28

Last Posted Date: 2016-03-25

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Registration Number: NCT00000478

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