Naloxone
- Generic Name
- Naloxone
- Brand Names
- Kloxxado, Narcan, Suboxone, Targin, Targiniq, Zimhi, Zubsolv, Nyxoid
- Drug Type
- Small Molecule
- Chemical Formula
- C19H21NO4
- CAS Number
- 465-65-6
- Unique Ingredient Identifier
- 36B82AMQ7N
- Background
Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other d...
- Indication
Naloxone nasal sprays are indicated for the reversal of an opioid overdose or suspected opioid overdose: it is intended for immediate administration as emergency therapy in settings where opioids may be present. Intramuscular, intravenous, and subcutaneous injections are indicated for complete or partial reversal of opioid depression, diagnosis of known or s...
- Associated Conditions
- Opioid Dependence, Opioid Overdose, Pruritus, Respiratory Depression, Septic Shock, Severe Pain, Moderate Pain, Suspected Opioid Overdose
- Associated Therapies
- Emergency Care
Role of Endorphins in Perception of Dyspnea With Resistive Loading in Chronic Obstructive Pulmonary Disease (COPD)
- Conditions
- Interventions
- First Posted Date
- 2009-08-14
- Last Posted Date
- 2013-04-11
- Lead Sponsor
- Dartmouth-Hitchcock Medical Center
- Target Recruit Count
- 14
- Registration Number
- NCT00958919
- Locations
- 🇺🇸
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
Efficacy of Intramuscular Naloxone 0.4mg. in Prophylaxis of Intrathecal Morphine Induced Pruritus After Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2009-04-30
- Last Posted Date
- 2011-07-25
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 60
- Registration Number
- NCT00890942
- Locations
- 🇹🇭
Anesthesiology department, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Abuse Liability of Suboxone Versus Subutex
- Conditions
- Interventions
- First Posted Date
- 2008-07-04
- Last Posted Date
- 2016-12-05
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 19
- Registration Number
- NCT00710385
- Locations
- 🇺🇸
New York State Psychiatric Institute/Columbia University, New York, New York, United States
Mechanisms of Hypoglycemia Associated Autonomic Failure
- First Posted Date
- 2008-05-15
- Last Posted Date
- 2021-01-14
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 116
- Registration Number
- NCT00678145
- Locations
- 🇺🇸
Albert Einstein College of Medicine / General Clinical Research Center, Bronx, New York, United States
Drug Discrimination in Methadone-Maintained Humans Study 1
- Conditions
- Interventions
- First Posted Date
- 2008-01-15
- Last Posted Date
- 2011-03-11
- Lead Sponsor
- University of Arkansas
- Target Recruit Count
- 40
- Registration Number
- NCT00593463
- Locations
- 🇺🇸
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Optimal Dose of Prophylactic Naloxone in Reducing Opioid-Induced Side Effects in Children/Adolescents
- First Posted Date
- 2006-05-26
- Last Posted Date
- 2017-07-19
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 75
- Registration Number
- NCT00330343
- Locations
- 🇺🇸
John Hopkins Hospital, Baltimore, Maryland, United States
Opioid Receptors Influence Ischemia-Reperfusion Injury
- Conditions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2008-03-28
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 40
- Registration Number
- NCT00184938
- Locations
- 🇳🇱
Radboud University Nijmegen Medical Centre / Department of Pharmacology and Toxicology, Nijmegen, Gelderland, Netherlands
Tramadol to Reduce Opioid Withdrawal Symptoms
- Conditions
- First Posted Date
- 2005-09-02
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 16
- Registration Number
- NCT00142896
- Locations
- 🇺🇸
Johns Hopkins University (BPRU) Bayview Campus, Baltimore, Maryland, United States
Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome
- Conditions
- First Posted Date
- 2005-04-18
- Last Posted Date
- 2009-01-21
- Lead Sponsor
- US Department of Veterans Affairs
- Registration Number
- NCT00108446
- Locations
- 🇺🇸
Malcom Randall VAMC, Gainesville, Florida, United States
Determine the Safety of a Sublingual Tablet Formulation of Buprenorphine and Naloxone by Extending the Combination Tablet Availability to Physicians in Office-Based Practice
- Conditions
- First Posted Date
- 2001-01-01
- Last Posted Date
- 2009-01-21
- Lead Sponsor
- US Department of Veterans Affairs
- Target Recruit Count
- 600
- Registration Number
- NCT00007527
- Locations
- 🇺🇸
Paul Casadonte, M.D. VAMC New York, New York, New York, United States
🇺🇸Andrew Saxon, M.D.-Addictions Treatment (116ATC), Seattle, Washington, United States
Drug Development Updates
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