Etoricoxib

Generic Name: Etoricoxib

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₁₅ClN_₂O_₂S

CAS Number: 202409-33-4

Unique Ingredient Identifier: WRX4NFY03R

Background: Etoricoxib is a new COX-2 selective inhibitor. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2) to reduce the generation of prostaglandins (PGs) from arachidonic acid. It is approved in more than 60 countries worldwide but not in the US.

Indication: For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.

Associated Conditions: Ankylosing Spondylitis (AS), Gout, Osteoarthritis (OA), Rheumatoid Arthritis, Moderate Pain

Associated Therapies: -

Clinical Trials

Immunomodulating Therapy and Improved Vaccination Responses by Cox-2 Inhibitor in HIV-infected Patients

Phase 2

Completed

Conditions: HIV

Interventions: Drug: Etoricoxib

First Posted Date: 2011-01-04

Last Posted Date: 2017-05-31

Lead Sponsor: Dag Kvale

Target Recruit Count: 60

Registration Number: NCT01269515

Locations: 🇳🇴
Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway
🇳🇴
The Biotechnology Centre, University of Oslo, Oslo, Norway

Evaluation of the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Neuropathic Pain

Phase 4

Conditions: Postherpetic Neuralgia
Neuralgia

Interventions: Drug: Placebo
Drug: Etoricoxib

First Posted Date: 2010-12-21

Last Posted Date: 2011-03-23

Lead Sponsor: Analgesic Solutions

Target Recruit Count: 120

Registration Number: NCT01264237

Locations: 🇬🇧
MAC (UK) Neuroscience Ltd, Manchester, United Kingdom
🇬🇧
MAC (UK) Neruoscience Ltd, Liverpool, United Kingdom

Efficacy Study of Pre-emptive Etoricoxib for Postoperative Pain and Functional Outcome in Total Knee Arthroplasty

Phase 2

Completed

Conditions: Knee Osteoarthritis

Interventions: Drug: Control
Drug: Etoricoxib

First Posted Date: 2010-11-23

Last Posted Date: 2017-02-10

Lead Sponsor: Singapore General Hospital

Target Recruit Count: 65

Registration Number: NCT01246362

Locations: 🇸🇬
Singapore General Hospital, Singapore, Singapore

Use of Etoricoxib Compared to Diclofenac in the Perioperative Treatment of Patients After Total Hip Arthroplasty

Phase 3

Completed

Conditions: Perioperative Blood Loss
Arthroplasties Hip Replacement
Coxarthrosis

Interventions: Drug: Etoricoxib
Drug: Diclofenac

First Posted Date: 2010-10-28

Last Posted Date: 2014-09-15

Lead Sponsor: University of Regensburg

Target Recruit Count: 100

Registration Number: NCT01229774

Locations: 🇩🇪
Department of Orthopedic Surgery, Bad Abbach, Bavaria, Germany

A Study Comparing Etoricoxib and Diclofenac Sodium in Post Hallux Valgus Surgery Pain

Phase 4

Withdrawn

Conditions: Postoperative Pain
Hallux Valgus

Interventions: Drug: etoricoxib
Drug: Diclofenac

First Posted Date: 2010-08-30

Last Posted Date: 2017-12-02

Lead Sponsor: Karolinska Institutet

Registration Number: NCT01190722

Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache

Phase 4

Completed

Conditions: Headache
Fasting
Fasting Headache
Ramadan Headache

Interventions: Drug: Etoricoxib
Drug: Placebo

First Posted Date: 2010-06-22

Last Posted Date: 2011-03-08

Lead Sponsor: Hartford Hospital

Target Recruit Count: 220

Registration Number: NCT01148303

Locations: 🇮🇱
Shaare Zedek Medical Center, Jerusalem, Israel

Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs

Phase 3

Completed

Conditions: Ankylosing Spondylitis

Interventions: Drug: Etoricoxib

First Posted Date: 2010-03-24

Last Posted Date: 2015-08-25

Lead Sponsor: Spanish Foundation of Rheumatology

Target Recruit Count: 58

Registration Number: NCT01091675

Locations: 🇪🇸
Hospital General of Mostoles, Madrid, Spain
🇪🇸
Central Hospital of Asturias, Oviedo, Asturias, Spain
🇪🇸
Sant Rafael Hospital, Barcelona, Spain

and more 11 locations