Simethicone
- Generic Name
- Simethicone
- Brand Names
- Phazyme
- Drug Type
- Small Molecule
- Chemical Formula
- C6H18O4Si3
- CAS Number
- 8050-81-5
- Background
Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed.
Simethicone has been in use since the 1940s but was granted FDA approval in 1952.
- Indication
Simethicone is indicated for the treatment of bloating, pressure, and cramps caused by gas. Simethicone is also used as part of bowel preparation for colonoscopies.
- Associated Conditions
- Abdominal Cramping, Abdominal Pain, Bloating, Colic, Diarrhea, Distension, Distention, Dyspepsia, Flatulence, Gastric Ulcer, Gastritis, Heartburn, Hiatus Hernia, Hyperacidity, Pain, Pancreatic Insufficiency, Peptic Esophagitis, Peptic Ulcer, Reflux Acid, Stomach ache, Gastrointestinal cramping, Gastrointestinal cramps caused by Gas, Gastrointestinal spasms, Stomach cramps
- Associated Therapies
- Antacid therapy, Bowel preparation therapy
Simethicone Protocol
- Conditions
- SimethiconeBariatric SurgeryPost-operative Pain
- Interventions
- Drug: Placebo
- First Posted Date
- 2025-02-06
- Last Posted Date
- 2025-02-06
- Lead Sponsor
- Madigan Army Medical Center
- Target Recruit Count
- 260
- Registration Number
- NCT06812832
Impact of Timing of Premedication on Mucosal Visibility During Endoscopy-A Randomized Controlled Trial
- First Posted Date
- 2024-09-03
- Last Posted Date
- 2025-05-06
- Lead Sponsor
- Asian Institute of Gastroenterology, India
- Target Recruit Count
- 1200
- Registration Number
- NCT06581783
- Locations
- 🇮🇳
Asian Institute of Gastroenterology /Aig Hospitals, Hyderabad, Telangana, India
Fixed Low-dose Simethicone Combined With Macrogol 4000 (PEG) Reduces Colon Bubble Formation in Colonoscopy
- Conditions
- ColonoscopyColorectal CancerBowel Preparation Solution
- First Posted Date
- 2024-03-20
- Last Posted Date
- 2024-03-20
- Lead Sponsor
- Hospital St. Joseph, Marseille, France
- Target Recruit Count
- 601
- Registration Number
- NCT06319924
- Locations
- 🇫🇷
Clinique des Cèdres, Ramsay Santé,, Cornebarrieu, France
🇫🇷Polyclinique Louis Pasteur,, Essey-les-Nancy, France
🇫🇷Saint Joseph Hospital, Marseille, France
Pre-medication With N-acetylcysteine and Simethicone to Improve Mucosal Visibility During Gastroduodenoscopy
- Conditions
- Mucosal Erosion
- Interventions
- Drug: N Acetyl cysteine 600mgOther: Placebo
- First Posted Date
- 2023-07-19
- Last Posted Date
- 2023-07-24
- Lead Sponsor
- Asian Institute of Gastroenterology, India
- Target Recruit Count
- 800
- Registration Number
- NCT05951712
- Locations
- 🇮🇳
Asian institute of Gastroenterology, Hyderabad, Telangana, India
Efficacy and Safety of Mebeverine + Simethicone in Patients With Functional Bowel Disorders
- Conditions
- Functional Bowel Disorder
- Interventions
- First Posted Date
- 2022-01-03
- Last Posted Date
- 2024-01-03
- Lead Sponsor
- Abbott
- Target Recruit Count
- 465
- Registration Number
- NCT05175131
- Locations
- 🇷🇺
Null Research Facilities, Moscow, Russian Federation
The Impact of Air Travel on Passenger Cognitive Functions
- Conditions
- Air Travel
- Interventions
- Drug: Cytochrome C6Drug: Sodium Chloride Oral ProductDrug: Sodium Citrate Oral ProductDrug: Dextrose Oral Tablet, ChewableDrug: Probiotic Formula
- First Posted Date
- 2021-03-17
- Last Posted Date
- 2021-03-17
- Lead Sponsor
- Dinara Zhumanbayeva
- Target Recruit Count
- 50
- Registration Number
- NCT04802785
Low-volume vs High-volume Polyethylene Glycol Based Bowel Preparation for Colonoscopy in People Receiving Hemodialysis
- Conditions
- Colon PolypChronic Kidney DiseasesColon CancerDialysis; Complications
- Interventions
- Dietary Supplement: Low-residue diet
- First Posted Date
- 2021-01-14
- Last Posted Date
- 2021-01-14
- Lead Sponsor
- Alfredo Di Leo
- Target Recruit Count
- 264
- Registration Number
- NCT04709770
Effects of Multilac Baby on Fecal Calprotectin Levels of Colicky Babies
- Conditions
- Infantile Colic
- Interventions
- Dietary Supplement: Multilac Baby
- First Posted Date
- 2020-12-14
- Last Posted Date
- 2020-12-14
- Lead Sponsor
- The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz
- Target Recruit Count
- 100
- Registration Number
- NCT04666324
- Locations
- 🇵🇱
GP Clinic "Pro Familia", Koziegłowy, Poland
🇵🇱GP Clinic "Panaceum", Brody, Poland
Effects of Vivatlac Baby on Crying Behavior of Colicky Babies
- Conditions
- Infantile Colic
- Interventions
- Dietary Supplement: Vivatlac Baby
- First Posted Date
- 2020-07-27
- Last Posted Date
- 2023-11-22
- Lead Sponsor
- The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz
- Target Recruit Count
- 87
- Registration Number
- NCT04487834
- Locations
- 🇵🇱
Medical University in Poznań, Poznan, Poland
🇵🇱GP Practice Pro Familia, Koziegłowy, Poland
A Study of Combination Caplet With Loperamide Hydrochloride and Simethicone, and Imodium Express Tablets-lyophilizate Coadministered With Espumisan Capsule in Healthy Volunteers
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2019-12-05
- Last Posted Date
- 2020-09-10
- Lead Sponsor
- McNeil AB
- Target Recruit Count
- 48
- Registration Number
- NCT04186936
- Locations
- 🇷🇺
"Scientific and Research centre Eco-safety" Limited Liability Company, Saint-Petersburg, Russian Federation
Drug Development Updates
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