Indomethacin
- Generic Name
- Indomethacin
- Brand Names
- Indocin, Tivorbex
- Drug Type
- Small Molecule
- Chemical Formula
- C19H16ClNO4
- CAS Number
- 53-86-1
- Unique Ingredient Identifier
- XXE1CET956
- Background
Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-ace...
- Indication
Oral indometacin is indicated for symptomatic management of moderate to severe rheumatoid arthritis including acute flares of chronic disease, moderate to severe ankylosing spondylitis, moderate to severe osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis.
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- Associated Conditions
- Acute Gouty Arthritis, Joint Pain, Moderate to Severe Osteoarthritis, Moderate to Severe Rheumatoid Arthritis, Moderate to severe ankylosing spondylitis, Myalgia, Patent Ductus Arteriosus (PDA), Acute Shoulder Pain
- Associated Therapies
- -
Effect of Indomethacin on the Progression of Alzheimer's Disease
- Conditions
- First Posted Date
- 2007-02-06
- Last Posted Date
- 2007-02-06
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 160
- Registration Number
- NCT00432081
- Locations
- 🇳🇱
Rijnstate Hospital, Arnhem, Netherlands
🇳🇱Radboud University Medical Center, Nijmegen, Netherlands
Treatment of Orthostatic Intolerance
- Conditions
- Interventions
- Drug: AtomoxetineDrug: AcetazolamideDietary Supplement: MelatoninOther: NO DrugDrug: Isosorbide DinitrateRadiation: PlaceboDevice: Breathing DeviceOther: Drinking WaterProcedure: IV SalineDevice: Abdominal binderDrug: IndomethacinDrug: MidodrineDrug: MecamylamineDrug: ClonidineDrug: EntacaponeDrug: memantineDrug: ModafinilDrug: OctreotideDrug: SertralineDrug: Atomoxetine & PropranololDrug: Entacapone & PropranololDrug: PropranololDrug: Modafinil & Propranolol
- First Posted Date
- 2005-12-06
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- Satish R. Raj
- Target Recruit Count
- 150
- Registration Number
- NCT00262470
- Locations
- 🇺🇸
Vanderbilt University Autonomic Dysfunction Center, Nashville, Tennessee, United States
The Effect of Indomethacin in Monosymptomatic Enuresis Nocturnal
- Conditions
- First Posted Date
- 2005-09-26
- Last Posted Date
- 2010-06-25
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 56
- Registration Number
- NCT00226122
- Locations
- 🇩🇰
Dept of Pediatrics, Aarhus University Hospital, Aarhus N, Jutland, Denmark
Treatment of Orthostatic Hypotension in Autonomic Failure
- Conditions
- Interventions
- Drug: AtomoxetineDrug: placeboDrug: AcarboseDevice: inflatable abdominal binder (sham)Drug: Pyridostigmine BromideDrug: YohimbineDrug: Midodrine HClDrug: ModafinilDrug: OctreotideOther: water intakeDrug: Diphenhydramine HydrochlorideDrug: Ranitidine HCLDrug: TranylcypromineDrug: Ergotamine/ CaffeineDrug: CelecoxibDrug: PseudoephedrineDrug: MethylphenidateDrug: IndomethacinDrug: IbuprofenDrug: Oxymetazoline 0.05% nasal solutionDietary Supplement: BovrilDrug: AcetazolamideDrug: Rivastigmine tartrateDrug: Carbidopa/levodopaDevice: Inflatable abdominal binder
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-01-18
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 389
- Registration Number
- NCT00223691
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer
- Conditions
- Interventions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2020-12-11
- Lead Sponsor
- Brooklyn ImmunoTherapeutics, LLC
- Target Recruit Count
- 27
- Registration Number
- NCT00210470
Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers
- Conditions
- First Posted Date
- 2005-09-09
- Last Posted Date
- 2017-11-01
- Lead Sponsor
- University Hospital, Angers
- Target Recruit Count
- 85
- Registration Number
- NCT00152724
- Locations
- 🇫🇷
Laboratoire de Physiologie et Explorations Vasculaires - CHU Angers, Angers, France
Magnesium Sulfate Versus Indomethacin for Preterm Labor
- Conditions
- First Posted Date
- 2005-06-30
- Last Posted Date
- 2016-08-15
- Lead Sponsor
- University of Pennsylvania
- Registration Number
- NCT00116623
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Indomethacin Plus Biological Therapy in Treating Patients With Advanced Melanoma
- Conditions
- First Posted Date
- 2004-07-29
- Last Posted Date
- 2013-06-26
- Lead Sponsor
- St. Luke's Medical Center
- Registration Number
- NCT00002535
- Locations
- 🇺🇸
St. Luke's Medical Center, Milwaukee, Wisconsin, United States
Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
- Conditions
- Interventions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-02-01
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 46
- Registration Number
- NCT00002796
- Locations
- 🇺🇸
Mount Sinai Medical Center, New York, New York, United States
Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial
- Conditions
- Interventions
- First Posted Date
- 2002-04-15
- Last Posted Date
- 2013-03-28
- Lead Sponsor
- Yale University
- Target Recruit Count
- 630
- Registration Number
- NCT00033917
- Locations
- 🇺🇸
Yale University School of Medicine, New Haven, Connecticut, United States
🇺🇸Maine Medical Center, Portland, Maine, United States
🇺🇸Brown University School of Medicine, Providence, Rhode Island, United States
Drug Development Updates
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