Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
...

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Ultrasound-Guided Extrafascial Versus Intrafascial Interscalene Brachial Plexus Block in Shoulder Arthroscopy

Not Applicable

Conditions: Arthroscopy
Intrafascial Interscalene Brachial Plexus Block
Analgesia

Interventions: Procedure: Intrafascial interscalene brachial plexus block
Procedure: Extrafascial interscalene brachial plexus block group
Drug: Bupivacaine

First Posted Date: 2022-02-03

Last Posted Date: 2022-02-03

Lead Sponsor: Tanta University

Target Recruit Count: 50

Registration Number: NCT05222334

The Effect of Caudal Block on Optic Nerve Sheath Diameter in Pediatric Patients

Not Applicable

Completed

Conditions: Postoperative Pain
Intracranial Hypertension

Interventions: Drug: Bupivacaine Hydrochloride

First Posted Date: 2022-01-31

Last Posted Date: 2022-12-23

Lead Sponsor: Ataturk University

Target Recruit Count: 60

Registration Number: NCT05216211

Locations: 🇹🇷
Ataturk University School of Medicine, Erzurum, Yakutiye, Turkey

Dexamethasone & Ketamine as Adjuvants to Bupivacaine for Incisional Infiltration in Pediatric Abdominal Operations

Not Applicable

Completed

Conditions: Pediatric ALL

Interventions: Drug: Bupivacaine
Drug: Dexamethasone
Drug: Ketamine

First Posted Date: 2022-01-13

Last Posted Date: 2022-01-13

Lead Sponsor: Ain Shams University

Target Recruit Count: 150

Registration Number: NCT05190952

Locations: 🇪🇬
Ain Shams university hospitals, Cairo, Al Abbassia, Egypt

Postoperative Pain Control by Use of Many Drugs in Small Doses Intrathecally

Phase 2

Conditions: Post Operative Pain

Interventions: Drug: Morphine Sulfate
Drug: dexamethasone, morphine, midazolam
Drug: Bupivacaine

First Posted Date: 2022-01-11

Last Posted Date: 2022-01-28

Lead Sponsor: Sohag University

Target Recruit Count: 60

Registration Number: NCT05186454

Locations: 🇪🇬
Fouad Soliman, Sohag, Egypt

Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs

Early Phase 1

Recruiting

Conditions: Ventral Hernia
Inguinal Hernia

Interventions: Drug: Liposomal Bupivacaine
Drug: Bupivacaine

First Posted Date: 2022-01-05

Last Posted Date: 2023-10-31

Lead Sponsor: Leslie Son

Target Recruit Count: 200

Registration Number: NCT05177991

Locations: 🇺🇸
Karl LeBlanc, Baton Rouge, Louisiana, United States

The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery

Phase 3

Recruiting

Conditions: Mammaplasty

Interventions: Procedure: Breast Reconstruction (Mammaplasty)
Device: Pecs blocks
Drug: Lidocaine
Drug: Bupivacaine
Drug: Exparel

First Posted Date: 2021-12-28

Last Posted Date: 2023-11-09

Lead Sponsor: Northwestern University

Target Recruit Count: 90

Registration Number: NCT05171179

Locations: 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States

Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy

Phase 3

Completed

Conditions: Bunionectomy
Hallux Valgus

Interventions: Drug: Bupivacaine liposome injectable suspension 266 mg
Drug: Bupivacaine liposome injectable suspension 133 mg
Drug: Bupivacaine HCl

First Posted Date: 2021-12-15

Last Posted Date: 2022-09-08

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 185

Registration Number: NCT05157841

Locations: 🇺🇸
Lotus Clinical Research, Pasadena, California, United States
🇺🇸
Midwest Clinical Research Center, Dayton, Ohio, United States
🇺🇸
HD Research- First Surgical Hospital, Bellaire, Texas, United States

and more 4 locations

Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

Phase 3

Completed

Conditions: Knee Osteoarthritis
Pain Management

Interventions: Drug: bupivacaine liposome injectable suspension
Drug: Bupivacaine Hydrochloride

First Posted Date: 2021-12-01

Last Posted Date: 2024-10-24

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 167

Registration Number: NCT05139030

Locations: 🇺🇸
Woodland International Research Group, Little Rock, Arkansas, United States
🇺🇸
Endeavor Clinical Trials, San Antonio, Texas, United States
🇺🇸
Lotus Clinical Research, Pasadena, California, United States

and more 3 locations