Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

The Comparison of Supraperiosteal Nerve Block With Opiate Analgesia in Alleviating the Pain of Toothache

Phase 4

Completed

Conditions: Toothache

Interventions: Drug: hydrocodone/acetaminophen
Drug: bupivacaine (supraperiosteal nerve block)

First Posted Date: 2007-12-14

Last Posted Date: 2014-03-24

Lead Sponsor: Albany Medical College

Target Recruit Count: 18

Registration Number: NCT00574015

Locations: 🇺🇸
Albany Medical Center Hospital, Albany, New York, United States

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Phase 4

Completed

Conditions: Osteoarthritis of the Knee

Interventions: Drug: ropivacaine
Drug: adrenaline
Drug: fentanyl
Drug: ketorolac
Drug: bupivacaine
Drug: morphine

First Posted Date: 2007-11-22

Last Posted Date: 2011-08-08

Lead Sponsor: Asker & Baerum Hospital

Target Recruit Count: 102

Registration Number: NCT00562627

Locations: 🇳🇴
Asker and Baerum Hospital, Rud, Norway

Continuous Bupivacaine Infusion Following Colonic Surgery

Not Applicable

Withdrawn

Conditions: Abdominal Surgery

Interventions: Drug: Bupivacaine
Drug: Saline

First Posted Date: 2007-11-14

Last Posted Date: 2018-05-21

Lead Sponsor: The Cleveland Clinic

Registration Number: NCT00557843

Fentanyl With or Without Bupivacaine in Reducing Pain in Patients Undergoing Video-Assisted Chest Surgery

Not Applicable

Completed

Conditions: Perioperative/Postoperative Complications
Pain

Interventions: Drug: Fentanyl citrate
Procedure: videothoracoscopy
Drug: Bupivacaine hydrocloride

First Posted Date: 2007-10-02

Last Posted Date: 2017-02-09

Lead Sponsor: Roswell Park Cancer Institute

Target Recruit Count: 30

Registration Number: NCT00538499

Locations: 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States

Phase 2 Dose-Ranging Study of SKY0402 for Prolonged Postoperative Analgesia in Subject Undergoing Hemorrhoidectomy

Phase 2

Completed

Conditions: Postoperative Pain

Interventions: Drug: SKY0402
Drug: Bupivacaine HCl

First Posted Date: 2007-09-14

Last Posted Date: 2021-03-04

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 100

Registration Number: NCT00529126

Locations: 🇬🇪
JSC Imereti Regional Clinical Hospital of the Name A. Dzotsenidze, Kutaisi, Georgia
🇬🇪
JSC K. Eristavi National Center of Experimental and Clinical Surgery, Tbilisi, Georgia
🇬🇪
Socieety with limited responsibility Proctology Center, Tbilisi, Georgia

and more 4 locations