Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Ultrasound-Guided Versus Conventional Method for Caudal Block
- Conditions
- Interventions
- First Posted Date
- 2018-02-09
- Last Posted Date
- 2018-02-09
- Lead Sponsor
- Omer Karaca
- Target Recruit Count
- 275
- Registration Number
- NCT03427437
- Locations
- 🇹🇷
Baskent University, Konya, Turkey
Suprazygomatic Block in Cleft Palate Surgery in Children
- Conditions
- Interventions
- First Posted Date
- 2018-01-26
- Last Posted Date
- 2018-09-24
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 80
- Registration Number
- NCT03412474
- Locations
- 🇪🇬
Assiut University Hospital, Assiut, Egypt
Safety and Efficacy of Addition of Hyaluronidase to Lidocaine and Bupivacaine in Scalp Nerves Block in Elective Craniotomy Operations, Comparative Study
- Conditions
- Interventions
- First Posted Date
- 2018-01-26
- Last Posted Date
- 2018-04-27
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 64
- Registration Number
- NCT03411330
- Locations
- 🇪🇬
Ahmed Abdalla Mohamed, Cairo, Egypt
Bupivacaine Versus Liposomal Bupivacaine For Breast Pain Management After Breast Recontruction
- Conditions
- Interventions
- First Posted Date
- 2018-01-08
- Last Posted Date
- 2020-07-22
- Lead Sponsor
- Case Comprehensive Cancer Center
- Registration Number
- NCT03393117
Laparoscopic Guided Transversus Abdominis Plane Block for Postoperative Analgesia After Pediatric Laparoscopic Surgery.
- First Posted Date
- 2018-01-03
- Last Posted Date
- 2020-07-14
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 44
- Registration Number
- NCT03388671
- Locations
- 🇪🇬
Pediatric hospital, faculty of medicine, Assiut university, Assiut, Assiut Governorate, Egypt
Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section
- Conditions
- Interventions
- First Posted Date
- 2017-12-26
- Last Posted Date
- 2020-01-13
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 26
- Registration Number
- NCT03383588
- Locations
- 🇺🇸
Albert Einstein College of Medicine/ Montefiore Medical Center, Bronx, New York, United States
Post C-Section Pain Control Using EXPAREL
- First Posted Date
- 2017-12-19
- Last Posted Date
- 2021-05-18
- Lead Sponsor
- University of Minnesota
- Registration Number
- NCT03377595
- Locations
- 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States
Fascia Iliaca Blocks for Pain Control After Total Hip Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2017-12-15
- Last Posted Date
- 2023-10-10
- Lead Sponsor
- Henry Ford Health System
- Target Recruit Count
- 122
- Registration Number
- NCT03375112
- Locations
- 🇺🇸
Henry Ford Hospital, Detroit, Michigan, United States
Effect of Ultra-low Dose Naloxone During Supraclavicular Brachial Plexus Block on Post-operative Opioi
- Conditions
- Interventions
- First Posted Date
- 2017-12-13
- Last Posted Date
- 2018-05-02
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 64
- Registration Number
- NCT03372486
- Locations
- 🇪🇬
Mansoura University, Central Hospital, emergency Unit, Mansourah, Dakahlia, Egypt
PEMF and PEC Blocks in Mastectomy Reconstruction Patients
- First Posted Date
- 2017-12-04
- Last Posted Date
- 2022-03-09
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 60
- Registration Number
- NCT03360214
- Locations
- 🇺🇸
Columbia University Irving Medical Center, New York, New York, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.