Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Four Quadrants Transverse Abdominus Plane (4Q-TAP) Block With Plain and Liposomal Bupivacaine vs. Thoracic Epidermal Analgesia (TEA) in Patients Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) on an Enhanced Recovery Pathway

Phase 3

Completed

Conditions: Peritoneal Cancer

Interventions: Drug: Local Anesthetic Solution
Drug: Bupivacaine HCl
Drug: Liposomal Bupivacaine

First Posted Date: 2017-12-02

Last Posted Date: 2022-02-18

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 75

Registration Number: NCT03359811

Locations: 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Post-operative Pain Relief in Laparoscopic Cholecystectomy

Not Applicable

Conditions: Postoperative Pain

Interventions: Drug: bupivacaine
Drug: morphine
Drug: fentanyl

First Posted Date: 2017-11-28

Last Posted Date: 2017-11-28

Lead Sponsor: Assiut University

Target Recruit Count: 120

Registration Number: NCT03355716

Wound Infiltration of Liposomal Bupivacaine v Plain Bupivacaine for Post-Op Pain Control in Elective Cesarean Delivery

Phase 4

Conditions: Bupivacaine
Pain, Postoperative

Interventions: Drug: Placebos
Drug: Bupivacaine
Drug: Liposomal bupivacaine

First Posted Date: 2017-11-27

Last Posted Date: 2018-01-18

Lead Sponsor: Brooke Army Medical Center

Target Recruit Count: 132

Registration Number: NCT03353363

Locations: 🇺🇸
Brooke Army Medical Center, Fort Sam Houston, Texas, United States

Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site Post-operative Pain Control

Phase 3

Recruiting

Conditions: Breast Cancer

Interventions: Behavioral: patient-reported pain scores
Drug: Bupivacaine
Other: saline

First Posted Date: 2017-11-22

Last Posted Date: 2024-12-05

Lead Sponsor: Memorial Sloan Kettering Cancer Center

Target Recruit Count: 144

Registration Number: NCT03351348

Locations: 🇺🇸
Memorial Sloan Kettering Commack (Consent and follow-up only), Commack, New York, United States
🇺🇸
Memorial Sloan Kettering Nassau (Consent and follow-up only), Uniondale, New York, United States
🇺🇸
Memorial Sloan Kettering Westchester (Consent and follow-up only), Harrison, New York, United States

and more 4 locations

Superficial Serratus Plane Block for Modified Radical Mastectomy and Axillary Lymph Node Disection

Not Applicable

Completed

Conditions: Pain, Postoperative
Opioid Consumption
Postoperative Analgesia

Interventions: Drug: Saline
Drug: Bupivacaine
Device: Ultrasound

First Posted Date: 2017-11-14

Last Posted Date: 2017-11-14

Lead Sponsor: Ataturk University

Target Recruit Count: 48

Registration Number: NCT03341234

Locations: 🇹🇷
Regional Training and Research Hospital, Erzurum, Turkey

Pharmacokinetics and Dynamics of Dexmedetomidine as Adjuvant in TAP Block

Phase 2

Completed

Conditions: Postoperative Pain

Interventions: Drug: bupivacaine
Drug: Dexmedetomidine

First Posted Date: 2017-11-01

Last Posted Date: 2020-10-22

Lead Sponsor: Assiut University

Target Recruit Count: 24

Registration Number: NCT03328299

Locations: 🇪🇬
South Egypt Cancer instIitute, Assuit, Egypt

Norepinephrine Versus Phenylephrine Continuous Variable Infusion in Cesarean Delivery

Phase 4

Completed

Conditions: Cesarean Section Complications
Spinal Anesthesia

Interventions: Drug: Phenylephrine
Drug: Norepinephrine
Drug: Bupivacaine

First Posted Date: 2017-11-01

Last Posted Date: 2018-07-17

Lead Sponsor: Cairo University

Target Recruit Count: 123

Registration Number: NCT03328533

Locations: 🇪🇬
Cairo University, Cairo, Egypt

Study of Peri-Articular Anaesthetic for Replacement of the Knee

Phase 3

Completed

Conditions: Knee Osteoarthritis

Interventions: Drug: Liposomal bupivacaine
Drug: Bupivacaine hydrochloride

First Posted Date: 2017-10-31

Last Posted Date: 2022-11-04

Lead Sponsor: University of Leeds

Target Recruit Count: 533

Registration Number: NCT03326180

Locations: 🇬🇧
The Royal Orthopaedic Hospital, Birmingham, United Kingdom
🇬🇧
The Whittington Hospital, London, United Kingdom
🇬🇧
Chapel Allerton Hospital, Leeds, United Kingdom

and more 8 locations