Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Minimal Opioid Use After Total Hip Replacement (THR)

Phase 4

Completed

Conditions: Osteoarthritis, Hip

Interventions: Procedure: Periarticular injection (Deep injection)
Drug: Bupivacaine
Procedure: Periarticular injection (Superficial injection)
Drug: Placebo

First Posted Date: 2017-03-24

Last Posted Date: 2024-12-27

Lead Sponsor: Hospital for Special Surgery, New York

Target Recruit Count: 180

Registration Number: NCT03090152

Locations: 🇺🇸
Hospital for Special Surgery, New York, New York, United States

PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery

Phase 2

Completed

Conditions: Breast Cancer Female
Cancer of Breast
Breast Cancer

Interventions: Drug: Bupivacaine
Drug: Gabapentin
Drug: Celecoxib
Drug: Acetaminophen
Drug: Midazolam
Drug: Fentanyl

First Posted Date: 2017-03-21

Last Posted Date: 2024-12-24

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 134

Registration Number: NCT03084536

Locations: 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States

TAP Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery

Phase 4

Completed

Conditions: Colorectal Surgery
TAP Blocks

Interventions: Drug: Exparel
Drug: Ropivacaine

First Posted Date: 2017-03-15

Last Posted Date: 2021-04-27

Lead Sponsor: University of California, Davis

Target Recruit Count: 86

Registration Number: NCT03080142

Locations: 🇺🇸
UC Davis Health, Sacramento, California, United States

Analgesic Efficacy of Ultrasound Guided Quadratus Lumborum Block During ESWL

Phase 4

Completed

Conditions: Pain, Acute

Interventions: Drug: Bupivacaine
Drug: Lidocaine

First Posted Date: 2017-03-15

Last Posted Date: 2017-11-14

Lead Sponsor: Ataturk University

Target Recruit Count: 40

Registration Number: NCT03080363

Locations: 🇹🇷
Ataturk University, Erzurum, Turkey

Ultrasound Guided Modified Thoracolumbar Interfascial Plane Block for Spinal Surgery

Phase 4

Completed

Conditions: Spine Disease
Pain, Postoperative

Interventions: Drug: Saline
Drug: Bupivacaine

First Posted Date: 2017-03-14

Last Posted Date: 2017-05-17

Lead Sponsor: Ataturk University

Target Recruit Count: 40

Registration Number: NCT03079076

Locations: 🇹🇷
Ataturk University, Erzurum, Turkey

The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta

Phase 1

Completed

Conditions: Coarctation of Aorta

Interventions: Device: ultrasound
Drug: Dexamethasone
Procedure: paravertebral block
Drug: Bupivacaine
Other: isotonic saline

First Posted Date: 2017-03-09

Last Posted Date: 2017-07-19

Lead Sponsor: Cairo University

Target Recruit Count: 50

Registration Number: NCT03074773

Locations: 🇪🇬
Amany Hassan Saleh, Cairo, Egypt

Neurostimulation in Pudendal Nerve Block

Not Applicable

Completed

Conditions: Penile Surgery

Interventions: Procedure: Pudendal nerve block
Drug: Bupivacaine

First Posted Date: 2017-03-07

Last Posted Date: 2017-03-07

Lead Sponsor: Hôpital d'enfants Béchir-Hamza

Target Recruit Count: 150

Registration Number: NCT03072329

Locations: 🇹🇳
Hôpital d'Enfants Béchir Hamza, Bab Saadoun, Tunis, Tunisia

A Trial of Levator Muscle Blocks Following Posterior Colporrhaphy Surgery to Reduce Post-operative Pain.

Not Applicable

Conditions: Post Operative Pain

Interventions: Drug: normal saline 0.9%
Drug: Bupivacaine

First Posted Date: 2017-03-01

Last Posted Date: 2019-01-07

Lead Sponsor: The Christ Hospital

Target Recruit Count: 128

Registration Number: NCT03067168

Locations: 🇺🇸
The Christ Hospital, Cincinnati, Ohio, United States
🇺🇸
The University of Toledo, Toledo, Ohio, United States
🇺🇸
The University of Kansas Medical Center, Kansas City, Kansas, United States