Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Transversus Abdominis Plane Block Using Dexmedetomidine and Bupivacaine

Phase 2

Completed

Conditions: Laparoscopic Orcheopexy

Interventions: Drug: Bupivacaine
Drug: Dexmedetomidine

First Posted Date: 2017-05-17

Last Posted Date: 2018-09-24

Lead Sponsor: Assiut University

Target Recruit Count: 80

Registration Number: NCT03156296

Locations: 🇪🇬
Assiut University Hospital, Assiut, Egypt

Safety and Efficacy of Three Local Block Techniques for Diabetic Foot Surgery

Not Applicable

Conditions: Anesthesia, Regional

Interventions: Procedure: sciatic nerve block
Procedure: ankle block
Drug: Bupivacaine

First Posted Date: 2017-05-16

Last Posted Date: 2017-06-15

Lead Sponsor: Assiut University

Target Recruit Count: 90

Registration Number: NCT03155568

The Effects of Different Anesthetic Techniques on QT, Corrected QT (QTc), and P Wave Dispersions in Cesarean Section

Phase 4

Completed

Conditions: Anesthesia; Reaction
Caesarean Section

Interventions: Drug: Bupivacaine
Drug: Sevoflurane

First Posted Date: 2017-05-01

Last Posted Date: 2017-05-09

Lead Sponsor: Trakya University

Target Recruit Count: 90

Registration Number: NCT03134677

Local Anesthetic Infiltration VS Trasversalis Fascia Block VS Spinal Anesthesia

Not Applicable

Conditions: Inguinal Hernia

Interventions: Procedure: Blind Local Anesthetic infiltration
Procedure: Transversals Fascia Block
Procedure: Spinal Anesthesia
Drug: Ropivacaine
Drug: Bupivacaine

First Posted Date: 2017-04-25

Last Posted Date: 2017-04-25

Lead Sponsor: Istituti Ospitalieri di Cremona

Target Recruit Count: 48

Registration Number: NCT03128216

Locations: 🇮🇹
ASST Cremona, Creom, Cremona, Italy

Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement

Phase 4

Withdrawn

Conditions: Degenerative Joint Disease
Osteoarthritis

Interventions: Drug: Bupivicaine + epinephrine
Drug: Ropivacaine
Drug: Ketorolac
Drug: Bupivacaine
Drug: Clonidine Injection

First Posted Date: 2017-04-18

Last Posted Date: 2022-10-27

Lead Sponsor: Rush University Medical Center

Registration Number: NCT03119038

Locations: 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States

Epidural and Intravenous Patient-Controlled Analgesia Following Lumbar Spinal Fusion Surgery

Phase 4

Terminated

Conditions: Pain

Interventions: Drug: Hydromorphone
Drug: Bupivacaine
Drug: Fentanyl

First Posted Date: 2017-04-14

Last Posted Date: 2023-10-26

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 46

Registration Number: NCT03115151

Locations: 🇺🇸
University Of Texas Southwestern Medical Center, Zale University Hospital, Dallas, Texas, United States
🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States