Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Phenylephrine Infusion in Cesarean Delivery

Phase 4

Conditions: Spinal Anesthesia
Cesarean Section Complications

Interventions: Drug: fixed infusion phenylephrine
Drug: single shot phenylephrine
Drug: variable infusion phenylephrine
Drug: Bupivacaine

First Posted Date: 2017-08-14

Last Posted Date: 2019-11-25

Lead Sponsor: Cairo University

Target Recruit Count: 255

Registration Number: NCT03248817

Locations: 🇪🇬
Cairo University, Cairo, Egypt

Vasopressor Infusion in Cesarean Delivery

Phase 4

Conditions: Spinal Anesthesia
Cesarean Section Complications

Interventions: Drug: Phenylephrine
Drug: Norepinephrine
Drug: Bupivacaine

First Posted Date: 2017-08-14

Last Posted Date: 2021-09-27

Lead Sponsor: Cairo University

Target Recruit Count: 120

Registration Number: NCT03248791

Locations: 🇪🇬
Cairo University, Cairo, Egypt

Regional Analgesia After Cesarean Section

Phase 4

Completed

Conditions: Pain, Postoperative
Pain, Neuropathic
Cesarean Section

Interventions: Procedure: TAP (transversus abdominis plane block)
Drug: Paracetamol
Procedure: QLB (quadratus lumborum block)
Procedure: subarachnoid anesthesia
Device: Stimuplex Ultra 360 needle
Drug: Ropivacaine
Drug: Ketoprofen
Procedure: PCA (patient controlled analgesia)
Drug: Metamizol
Drug: Bupivacaine

First Posted Date: 2017-08-09

Last Posted Date: 2020-02-18

Lead Sponsor: Medical University of Lublin

Target Recruit Count: 105

Registration Number: NCT03244540

Locations: 🇵🇱
Szpital Specjalistyczny PRO-FAMILIA w Rzeszowie, Rzeszów, Poland
🇵🇱
Szpital Kliniczny Dzieciątka Jezus, Warszawa, Poland

Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)

Phase 3

Completed

Conditions: Postoperative Pain

Interventions: Drug: HTX-011
Drug: Saline placebo
Drug: Bupivacaine HCl
Device: Luer-lock applicator
Device: Vial access device

First Posted Date: 2017-08-02

Last Posted Date: 2021-10-27

Lead Sponsor: Heron Therapeutics

Target Recruit Count: 418

Registration Number: NCT03237481

Locations: 🇺🇸
Trovare Clinical Research, Inc., Bakersfield, California, United States
🇺🇸
Alliance Research Centers, Laguna Hills, California, United States
🇺🇸
Westside Surgical Hospital, Houston, Texas, United States

and more 21 locations

Vasopressor Prophylaxis After Spinal Anesthesia

Phase 4

Completed

Conditions: Cesarean Section Complications

Interventions: Drug: Norepinephrine 0.05 mcg /Kg/min
Drug: Norepinephrine 0.1 mcg /Kg/min
Drug: Norepinephrine 0.15 mcg /Kg/min
Drug: Bupivacaine

First Posted Date: 2017-07-31

Last Posted Date: 2019-01-15

Lead Sponsor: Cairo University

Target Recruit Count: 270

Registration Number: NCT03234816

Locations: 🇪🇬
Cairo University, Cairo, Egypt

Intrathecal Morphine for Unilateral Total Knee Arthroplasty

Not Applicable

Completed

Conditions: Primary Osteoarthritis of Knee Nos

Interventions: Procedure: No IT morphine
Procedure: 50 ug IT morphine
Procedure: 100 ug IT morphine
Drug: Morphine
Drug: Bupivacaine

First Posted Date: 2017-07-28

Last Posted Date: 2021-05-24

Lead Sponsor: Mahidol University

Target Recruit Count: 131

Registration Number: NCT03232957

Locations: 🇹🇭
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok, Thailand

Spinal Prilocaine for Caesarian Sections

Not Applicable

Completed

Conditions: Prilocaine
Combined Spinal Epidural Anesthesia
Pain
Bupivacaine

Interventions: Procedure: combined spinal epidural anaesthesia
Drug: Bupivacaine
Drug: Prilocaine

First Posted Date: 2017-07-17

Last Posted Date: 2022-08-05

Lead Sponsor: University Hospital, Antwerp

Target Recruit Count: 182

Registration Number: NCT03219086

Locations: 🇧🇪
AZ KLina, Brasschaat, Antwerp, Belgium
🇧🇪
AZ Middelheim, Berchem, Antwerpen, Belgium
🇧🇪
University Hospital Antwerp, Antwerp, Belgium

Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery

Phase 3

Recruiting

Conditions: Liver and Intrahepatic Bile Duct Disorder

Interventions: Drug: Bupivacaine
Drug: Fentanyl
Drug: Liposomal Bupivacaine
Drug: Hydromorphone Hydrochloride
Device: Implanted Medical Device
Behavioral: Questionnaire