Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Effects of Thoracic Epidural Administered Ropivacaine Versus Bupivacaine on Bladder Function

Phase 4

Completed

Conditions: Post Operative Urinary Retention

Interventions: Drug: Ropivacaine 2mg/ml
Drug: Bupivacaine
Device: 6 French transurethral dual channel catheter (Gaeltec, Dunvegan, Scotland)
Device: 14 French rectal balloon catheter (Gaeltec, Dunvegan, Scotland)

First Posted Date: 2015-04-10

Last Posted Date: 2017-05-18

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 42

Registration Number: NCT02414373

Locations: 🇨🇭
Patrick Wuethrich, Department of Anaesthesiology and Pain Therapy, University Hospital Bern Inselspital Bern, Bern, BE, Switzerland

Comparative Study of Ultrasound-guided Paravertebral Block Versus Intravenous Tramadol in Percutaneous Nephrolithotomy

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Group Tramadol
Procedure: Ultrasound-guided Paravertebral Block
Drug: Bupivacaine
Device: Ultrasound

First Posted Date: 2015-04-09

Last Posted Date: 2017-03-22

Lead Sponsor: Cukurova University

Target Recruit Count: 53

Registration Number: NCT02412930

Locations: 🇹🇷
Cukurova University Faculty of Medicine, Adana, Turkey

Anesthetics in Rhytidoplasty - A Comparison Study

Not Applicable

Completed

Conditions: Rhytidoplasty

Interventions: Drug: clonidine
Drug: glycopyrrolate
Drug: propofol
Drug: scopolamine
Drug: ketamine
Drug: midazolam
Device: ondansetron
Drug: marcaine
Drug: lidocaine
Drug: metoclopramide
Drug: famotidine
Drug: desflurane
Drug: sevoflurane

First Posted Date: 2015-04-07

Last Posted Date: 2015-04-07

Lead Sponsor: Mercy Facial Plastic Surgery Center

Target Recruit Count: 30

Registration Number: NCT02410460

Locations: 🇺🇸
Mercy Facial Plastic Surgery Center, Springfield, Missouri, United States

Obturator Nerve Block in Patients With Hip Fracture

Phase 4

Withdrawn

Conditions: Hip Fractures

Interventions: Drug: Saline
Drug: Bupivacaine

First Posted Date: 2015-04-03

Last Posted Date: 2015-09-14

Lead Sponsor: University of Aarhus

Registration Number: NCT02408419

Locations: 🇩🇰
Aarhus University Hospital, Aarhus, Denmark

TAP Block With Liposomal Bupivacaine Versus Pre-incisional Wound Infiltration With Bupivacaine for Postoperative Pain

Phase 1

Terminated

Conditions: Postoperative Pain

Interventions: Procedure: Pre-incisional wound infiltration
Procedure: Laparoscope to place TAP block with liposomal bupivacaine
Drug: Bupivacaine
Drug: Liposomal bupivacaine
Drug: Ketorolac

First Posted Date: 2015-03-27

Last Posted Date: 2020-04-28

Lead Sponsor: University of Tennessee

Target Recruit Count: 69

Registration Number: NCT02400645

Transversus Abdominis Plane Versus Caudal Block for Pediatrics

Phase 1

Completed

Conditions: Lower Abdominal Surgery

Interventions: Other: Caudal block
Other: Transversus abdominis plane block
Drug: Bupivacaine

First Posted Date: 2015-03-25

Last Posted Date: 2015-09-16

Lead Sponsor: Mansoura University

Target Recruit Count: 28

Registration Number: NCT02398123

Locations: 🇪🇬
Mansoura University, Mansoura, DK, Egypt

is There an Alternative to Ultrasound Guided Interscalene Block?

Not Applicable

Conditions: Shoulder Surgery
Regional Anesthesia
Interscalene Block

Interventions: Drug: bupivacaine
Device: ultrasound
Drug: morphine

First Posted Date: 2015-03-24

Last Posted Date: 2015-03-24

Lead Sponsor: Tunisian Military Hospital

Target Recruit Count: 60

Registration Number: NCT02397330

Exparel for Pain Control During Care of Rib Fractures

Phase 4

Withdrawn

Conditions: Pain

Interventions: Drug: EXPAREL

First Posted Date: 2015-03-17

Last Posted Date: 2017-01-19

Lead Sponsor: Michael Moncure, MD

Registration Number: NCT02390440

Locations: 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States

Caudal Bupivacaine vs Bupivacaine Plus Two Doses of Dexmedetomidine for Postoperative Analgesia in Children

Phase 2

Completed

Conditions: Pain, Postoperative

Interventions: Drug: dexmedetomidine 1μg.kg-1
Drug: dexmedetomidine 2μg.kg-1
Drug: Bupivacaine

First Posted Date: 2015-03-11

Last Posted Date: 2015-03-11

Lead Sponsor: University of Jordan

Target Recruit Count: 91

Registration Number: NCT02385435

Exparel Injection for Postoperative Orbital Pain

Phase 4

Recruiting

Conditions: Pain, Postoperative

Interventions: Drug: Bupivacaine

First Posted Date: 2015-03-06

Last Posted Date: 2024-06-13

Lead Sponsor: Mayo Clinic

Target Recruit Count: 88

Registration Number: NCT02381353

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
🇺🇸
University of Michigan Kellogg Eye Institute, Ann Arbor, Michigan, United States

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