Pentoxifylline

Generic Name: Pentoxifylline

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈N_₄O_₃

CAS Number: 6493-05-6

Unique Ingredient Identifier: SD6QCT3TSU

Background: Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties. Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated...

Indication: Pentoxifylline is indicated for the treatment of intermittent claudication in patients with chronic occlusive arterial disease. Pentoxifylline may improve limb function and reduce symptoms but cannot replace other therapies such as surgical bypass or removal of vascular obstructions.

Associated Conditions: Intermittent Claudication, Venous Leg Ulcer (VLU), Severe alcoholic liver disease

Associated Therapies: -

Clinical Trials

Trental for the Treatment of Vertigo/Dizziness/Imbalance

Not Applicable

Terminated

Conditions: Dizziness
Vertigo

Interventions: Drug: Placebo
Drug: Pentoxifylline

First Posted Date: 2015-10-30

Last Posted Date: 2024-10-11

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 26

Registration Number: NCT02592863

Locations: 🇺🇸
University of Missouri, Columbia, Missouri, United States

The Association of Miltefosine and Pentoxifylline to Treat Mucosal and Cutaneous Leishmaniasis: A Clinical Trial in Brazil

Phase 2

Active, not recruiting

Conditions: Leishmaniasis

Interventions: Drug: Meglumine antimoniate
Drug: Miltefosine
Drug: Pentoxifylline

First Posted Date: 2015-08-21

Last Posted Date: 2024-01-16

Lead Sponsor: University of Brasilia

Target Recruit Count: 160

Registration Number: NCT02530697

Locations: 🇧🇷
Hospital Universitário de Brasília, Brasília, DF, Brazil

Pentoxifylline Treatment in Acute Pancreatitis (AP)

Phase 3

Completed

Conditions: Idiopathic (Unknown) Acute Pancreatitis
Gallstone Pancreatitis
Acute Pancreatitis (AP)
Trauma Acute Pancreatitis
Medication Induced Acute Pancreatitis
Cancer Acute Pancreatitis
Hypertriglyceridemia Acute Pancreatitis
Miscellaneous (i.e. Acute on Chronic Pancreatitis)
Alcoholic Pancreatitis

Interventions: Drug: Placebo
Drug: Pentoxifylline

First Posted Date: 2015-07-01

Last Posted Date: 2019-01-23

Lead Sponsor: Mayo Clinic

Target Recruit Count: 83

Registration Number: NCT02487225

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

The Impact of Pentoxifylline and Vitamin E on Radiotherapy-induced Toxicity in Head & Neck Cancer Patients

Phase 2

Completed

Conditions: Head and Neck Neoplasms

Interventions: Drug: Pentoxifylline
Drug: Vitamin E
Drug: Cisplatin
Radiation: Radiation therapy

First Posted Date: 2015-03-25

Last Posted Date: 2019-11-26

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT02397486

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt

The Effect of Pentoxifylline on Liver Function Tests in Fatty Liver Disease

Phase 2

Completed

Conditions: Fatty Liver

Interventions: Behavioral: Lifestyle modification
Drug: Pentoxifylline

First Posted Date: 2014-11-05

Last Posted Date: 2014-11-06

Lead Sponsor: Tehran University of Medical Sciences

Target Recruit Count: 120

Registration Number: NCT02283710

Locations: 🇮🇷
Gastroenterology clinic, Sina Hospital, Tehran, Iran, Islamic Republic of

Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients

Phase 4

Conditions: Hepacivirus
HIV Infections

Interventions: Drug: Placebo
Drug: Pentoxifylline

First Posted Date: 2013-12-11

Last Posted Date: 2013-12-11

Lead Sponsor: Centro Universitario de Ciencias de la Salud, Mexico

Target Recruit Count: 60

Registration Number: NCT02008214

Locations: 🇲🇽
Hospital Civil de Guadalajara, Guadalajara, Jalisco, Mexico

Bromocriptine and Pentoxifylline in Ophthalmopathy Autoimmune Treatment

Not Applicable

Terminated

Conditions: Graves Ophthalmopathy

Interventions: Drug: Bromocriptine
Drug: Methimazole
Drug: Pentoxifylline

First Posted Date: 2013-07-09

Last Posted Date: 2013-07-09

Lead Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Target Recruit Count: 31

Registration Number: NCT01893450

Locations: 🇲🇽
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico

Safety of Pentoxifylline and Vitamin E With Stereotactic Ablative Radiotherapy (SABR) in Non-small Cell Lung Cancers

Phase 2

Recruiting

Conditions: Non-small Cell Lung Cancers

Interventions: Radiation: stereotactic ablative radiotherapy (SABR)
Drug: Pentoxifylline

First Posted Date: 2013-06-06

Last Posted Date: 2024-02-07

Lead Sponsor: University of Louisville

Target Recruit Count: 59

Registration Number: NCT01871454

Locations: 🇺🇸
James Graham Brown Cancer Center, U of Louisville, Louisville, Kentucky, United States

Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis

Phase 2

Completed

Conditions: Acute Alcoholic Hepatitis

Interventions: Drug: Anakinra
Drug: Methylprednisolone
Drug: Pentoxifylline
Drug: Zinc Sulfate

First Posted Date: 2013-03-12

Last Posted Date: 2021-11-01

Lead Sponsor: Mack Mitchell

Target Recruit Count: 104

Registration Number: NCT01809132

Locations: 🇺🇸
University of Louisville, Louisville, Kentucky, United States
🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

and more 1 locations

Pentoxifylline Therapy in Biliary Atresia

Phase 2

Terminated

Conditions: Biliary Atresia

Interventions: Drug: Pentoxifylline

First Posted Date: 2013-01-24

Last Posted Date: 2024-01-11

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 17

Registration Number: NCT01774487

Locations: 🇺🇸
Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, United States

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