Cefazolin
- Generic Name
- Cefazolin
- Drug Type
- Small Molecule
- Chemical Formula
- C14H14N8O4S3
- CAS Number
- 25953-19-9
- Unique Ingredient Identifier
- IHS69L0Y4T
- Background
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
- Indication
Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
- Associated Conditions
- Bacterial Septicemia caused by susceptible Bacterial Infections, Biliary tract infection bacterial caused by susceptible Bacterial Infections, Bone and Joint Infections caused by susceptible Bacterial Infections, Catheter-related Bloodstream Infection (CRBSI) NOS, Community Acquired Pneumonia (CAP), Endocarditis caused by susceptible Bacterial Infections, Genital infection caused by susceptible Bacterial Infections, Osteoarticular Infections, Postoperative Infections, Respiratory Tract Infection Bacterial caused by susceptible Bacterial Infections, Skin and Soft Tissue Infections (SSTIs), Skin and Subcutaneous Tissue Infection caused by susceptible Bacterial Infections, Susceptible infections, Urinary Tract Infection caused by susceptible Bacterial Infections, Perioperative infection, Susceptible Bacterial Infections
- Associated Therapies
- Antibiotic pre-surgical prophylaxis
Antibiotic Prophylaxis in Bariatric Surgery With Cefazolin: Concentration in Adipose Tissue
- First Posted Date
- 2013-05-03
- Last Posted Date
- 2013-05-03
- Lead Sponsor
- Universidade Federal de Pernambuco
- Target Recruit Count
- 18
- Registration Number
- NCT01845363
- Locations
- 🇧🇷
Universidade Federal de Pernambuco - Hospital das Clínicas, Recife, Pernambuco, Brazil
PROPHYLACTIC ANTIBIOTICS PRIOR TO CESAREAN SECTION IN OBESE WOMEN
- First Posted Date
- 2013-03-13
- Last Posted Date
- 2014-07-24
- Lead Sponsor
- Women and Infants Hospital of Rhode Island
- Target Recruit Count
- 58
- Registration Number
- NCT01810354
- Locations
- 🇺🇸
Women & Infants Hospital, Providence, Rhode Island, United States
Antimicrobial Prophylaxis in Thyroid and Parathyroid Surgery
- Conditions
- Thyroid DiseaseParathyroid Disease
- Interventions
- First Posted Date
- 2013-03-06
- Last Posted Date
- 2013-03-06
- Lead Sponsor
- Ito Hospital
- Target Recruit Count
- 2164
- Registration Number
- NCT01805856
- Locations
- 🇯🇵
Ito Hospital, Tokyo, Japan
Staphylococcus Aureus Bacteremia Antibiotic Treatment Options
- Conditions
- Staphylococcus Aureus Infection
- Interventions
- Drug: Trimethoprim-Sulfamethoxazole
- First Posted Date
- 2013-02-15
- Last Posted Date
- 2020-05-27
- Lead Sponsor
- Heinrich-Heine University, Duesseldorf
- Target Recruit Count
- 215
- Registration Number
- NCT01792804
- Locations
- 🇳🇱
Amsterdam, Amsterdam, Netherlands
🇳🇱Tilburg, Tilburg, Netherlands
🇳🇱Diakonessenhuis Utrecht, Utrecht, Netherlands
Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in CAPD Patients
- Conditions
- Peritonitis
- Interventions
- Drug: ceftazidime+ciprofloxacinDrug: cefazolin+gentamicin
- First Posted Date
- 2013-02-07
- Last Posted Date
- 2024-02-21
- Lead Sponsor
- Chulalongkorn University
- Target Recruit Count
- 300
- Registration Number
- NCT01785641
- Locations
- 🇹🇭
Chulalongkorn university, Bangkok, Thailand
Serum and Tissue Cefazolin Concentrations in Patients Undergoing Cesarean Delivery
- First Posted Date
- 2012-12-21
- Last Posted Date
- 2013-08-21
- Lead Sponsor
- Michael Stitely
- Target Recruit Count
- 23
- Registration Number
- NCT01755026
- Locations
- 🇺🇸
West Virginia University Hospital, Morgantown, West Virginia, United States
Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis
- First Posted Date
- 2012-11-06
- Last Posted Date
- 2015-05-05
- Lead Sponsor
- University of Missouri, Kansas City
- Registration Number
- NCT01721616
- Locations
- 🇺🇸
Truman Medical Center - Hospital Hill, Kansas City, Missouri, United States
Pre-operative Prophylaxis With Vancomycin and Cefazolin in Pediatric Cardiovascular Surgery Patients
- Conditions
- Congenital Heart DiseasesAortic Valve Disorder
- Interventions
- First Posted Date
- 2012-06-15
- Last Posted Date
- 2018-05-16
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 32
- Registration Number
- NCT01619982
- Locations
- 🇺🇸
Lucile Packard Children's Hospital at Stanford, Palo Alto, California, United States
Prevention of Arrhythmia Device Infection Trial (PADIT)
- First Posted Date
- 2012-06-06
- Last Posted Date
- 2014-10-10
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 241
- Registration Number
- NCT01613092
- Locations
- 🇨🇦
University of Ottawa Heart Institute, Ottawa, Ontario, Canada
🇨🇦Hamilton General Hospital, McMaster University, Hamilton, Ontario, Canada
Tissue and Plasma Pharmacokinetics of Cefazolin in Antibiotic Prophylaxis in Bariatric Surgery
- First Posted Date
- 2012-02-23
- Last Posted Date
- 2017-07-19
- Lead Sponsor
- Nantes University Hospital
- Target Recruit Count
- 117
- Registration Number
- NCT01537380
- Locations
- 🇫🇷
Nantes University Hospital, Nantes, France
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.