Roche Holding AG

Roche Holding AG logo
🇨🇭Switzerland
Ownership
Public
Established
1896-01-15
Employees
103.6K
Market Cap
$270.5B
Website
http://www.roche.com

A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

First Posted Date
2020-05-29
Last Posted Date
2024-10-16
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
270
Registration Number
NCT04408638
Locations
🇵🇱

Uniwersytecki Szpital Kliniczny; Klinika Hematologii, Terapii Komórkowych i Chorób Wewn?trznych, Wroc?aw, Poland

🇺🇸

University of Alabama at Birmingham, Birmingham, Alabama, United States

🇺🇸

Community Cancer Institute (CCI), Fresno, California, United States

and more 64 locations

A Study Evaluating The Safety, Efficacy and Pharmacokinetics Of Ipatasertib In Combination With Atezolizumab And Docetaxel In Metastatic Castration-Resistant Prostate Cancer (mCRPC).

First Posted Date
2020-05-27
Last Posted Date
2023-10-17
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
6
Registration Number
NCT04404140
Locations
🇫🇷

Gustave Roussy, Villejuif, France

🇪🇸

Hospital Ramon y Cajal; Servicio de Oncologia, Madrid, Spain

🇫🇷

Centre Val Aurelle Paul Lamarque; Radiotherapie, Montpellier, France

and more 6 locations

A Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants With Alzheimer's Disease (AD)

Phase 3
Terminated
Conditions
Interventions
First Posted Date
2020-05-05
Last Posted Date
2024-05-08
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
1382
Registration Number
NCT04374253
Locations
🇺🇸

Research Center for Clinical Studies, Inc., Norwalk, Connecticut, United States

🇺🇸

Brain Matters Research, Inc., Delray Beach, Florida, United States

🇺🇸

Infinity Clinical Research, LLC, Sunrise, Florida, United States

and more 265 locations

A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia

Phase 2
Completed
Conditions
Interventions
First Posted Date
2020-04-27
Last Posted Date
2022-08-31
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
97
Registration Number
NCT04363736
Locations
🇺🇸

St Joseph's Regional Medical Center, Wayne, New Jersey, United States

🇺🇸

St. Jude Medical Center, Fullerton, California, United States

🇺🇸

Advocate Christ Medical Center, Oak Lawn, Illinois, United States

and more 21 locations

A Study Of The Pharmacokinetics And Safety Of Ipatasertib In Chinese Participants With Locally Advanced Or Metastatic Solid Tumors.

Phase 1
Completed
Conditions
Interventions
First Posted Date
2020-04-10
Last Posted Date
2023-05-08
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
12
Registration Number
NCT04341259
Locations
🇨🇳

Fudan University Shanghai Cancer Center, Shanghai City, China

A Study to Evaluate the Safety and Tolerability of Long-term Administration of Gantenerumab in Participants With Alzheimer's Disease (AD)

Phase 3
Terminated
Conditions
Interventions
First Posted Date
2020-04-09
Last Posted Date
2024-01-18
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
116
Registration Number
NCT04339413
Locations
🇦🇷

Instituto Neurologia Bs As, Ciudad Autonoma Buenos Aires, Argentina

🇯🇵

Juntendo University Urayasu Hospital; Neurology, Chiba, Japan

🇵🇱

NZOZ NEURO-KARD Ilkowski i Partnerzy Sp. Partn. Lek, Pozna?, Poland

and more 53 locations

A Study of Atezolizumab in Combination With Cabozantinib Compared to Cabozantinib Alone in Participants With Advanced Renal Cell Carcinoma After Immune Checkpoint Inhibitor Treatment

Phase 3
Active, not recruiting
Conditions
Interventions
First Posted Date
2020-04-08
Last Posted Date
2024-10-09
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
522
Registration Number
NCT04338269
Locations
🇺🇸

Texas Oncology - Central South, Austin, Texas, United States

🇺🇸

University of Arizona, Tucson, Arizona, United States

🇺🇸

City of Hope Comprehensive Cancer Center, Duarte, California, United States

and more 140 locations

A Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases

First Posted Date
2020-04-08
Last Posted Date
2024-12-09
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
55
Registration Number
NCT04338685
Locations
🇩🇰

Rigshospitalet; Onkologisk Klinik, København Ø, Denmark

🇺🇸

City of Hope Cancer Center, Duarte, California, United States

🇭🇰

Queen Mary Hospital; Dept of Medicine, Hong Kong, Hong Kong

and more 7 locations

A Study to Investigate the Efficacy and Safety of Atezolizumab (Tecentriq) in Previously-Treated Patients With Advanced Thymic Carcinoma

Phase 2
Completed
Conditions
Interventions
First Posted Date
2020-03-25
Last Posted Date
2024-06-11
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
34
Registration Number
NCT04321330
Locations
🇨🇳

West China Hospital, Sichuan University; Department of Breast, Chengdu, China

🇨🇳

Sichuan Cancer Hospital, Chengdu City, China

🇨🇳

The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

and more 7 locations

A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia

Phase 3
Completed
Conditions
Interventions
First Posted Date
2020-03-25
Last Posted Date
2021-06-30
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
452
Registration Number
NCT04320615
Locations
🇺🇸

Ochsner Clinic Foundation, Baton Rouge, Louisiana, United States

🇺🇸

Robert Wood Johnson University Hospital/Rutgers, New Brunswick, New Jersey, United States

🇨🇦

University Health Network, Toronto, Ontario, Canada

and more 59 locations
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