Children's Oncology Group

🇺🇸United States

Country: 🇺🇸United States

Ownership: -

Employees: -

Market Cap: -

Website

Clinical Trials

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

Phase 3

Recruiting

Conditions: Embryonal Rhabdomyosarcoma
Fusion-Negative Alveolar Rhabdomyosarcoma
Spindle Cell/Sclerosing Rhabdomyosarcoma

Interventions: Procedure: Biopsy
Procedure: Bone Scan
Procedure: Computed Tomography
Drug: Cyclophosphamide
Biological: Dactinomycin
Procedure: Magnetic Resonance Elastography
Procedure: Positron Emission Tomography
Radiation: Radiation Therapy
Drug: Vincristine

First Posted Date: 2022-03-31

Last Posted Date: 2024-12-04

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 205

Registration Number: NCT05304585

Locations: 🇺🇸
Cleveland Clinic Foundation, Cleveland, Ohio, United States
🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States
🇦🇺
Sydney Children's Hospital, Randwick, New South Wales, Australia

and more 155 locations

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Phase 3

Recruiting

Conditions: Metastatic Malignant Neoplasm in the Lung
Osteosarcoma
Metastatic Osteosarcoma

Interventions: Procedure: Biospecimen Collection
Procedure: Computed Tomography
Other: Questionnaire Administration
Procedure: Thoracoscopy
Procedure: Thoracotomy

First Posted Date: 2022-02-11

Last Posted Date: 2024-12-04

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 250

Registration Number: NCT05235165

Locations: 🇺🇸
Ascension Borgess Hospital, Kalamazoo, Michigan, United States
🇺🇸
Presbyterian Hospital, Albuquerque, New Mexico, United States
🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States

and more 227 locations

Evaluation of Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer

Recruiting

Conditions: Malignant Solid Neoplasm
Hematopoietic and Lymphatic System Neoplasm
COVID-19 Infection

Interventions: Procedure: Biospecimen Collection
Other: Survey Administration

First Posted Date: 2022-02-08

Last Posted Date: 2024-12-04

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 549

Registration Number: NCT05228275

Locations: 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸
Kingman Regional Medical Center, Kingman, Arizona, United States
🇺🇸
UCSF Benioff Children's Hospital Oakland, Oakland, California, United States

and more 69 locations

Genetic Overlap Between Anomalies and Cancer in Kids in the Children's Oncology Group: The COG GOBACK Study

Recruiting

Conditions: Congenital Anomaly
Pediatric Cancer

Interventions: Other: Whole Genome Sequencing
Other: Questionnaire Administration
Other: Biospecimen collection
Other: Laboratory Biomarker Analysis

First Posted Date: 2021-10-08

Last Posted Date: 2024-12-20

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 1000

Registration Number: NCT05071859

Locations: 🇺🇸
Baylor College of Medicine/ Dan L Duncan Comprehensive Cancer Center, Houston, Texas, United States

Pilot Study to Enable Electronic Laboratory Data Transfer From Participating Institutions to MediData/RAVE

Active, not recruiting

Conditions: Accurate and Complete Data Acquisition for Clinical Trials

Interventions: Other: Medidata RAVE

First Posted Date: 2021-08-25

Last Posted Date: 2024-11-25

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 118

Registration Number: NCT05020951

Locations: 🇺🇸
Seattle Children's Hospital, Seattle, Washington, United States
🇺🇸
Memorial Sloan Kettering Cancer Center, New York, New York, United States
🇺🇸
Texas Children's Hospital, Houston, Texas, United States

and more 5 locations

Backtracking Leukemia-Typical Somatic Mutations in Cord Blood

Recruiting

Conditions: Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia

Interventions: Other: Cord blood Sample Collection
Other: Case identification and recruitment
Other: Questionnaire Administration

First Posted Date: 2021-08-20

Last Posted Date: 2024-12-13

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 300

Registration Number: NCT05014165

Locations: 🇺🇸
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota, United States

A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma

First Posted Date: 2021-08-06

Last Posted Date: 2024-12-20

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 118

Registration Number: NCT04994132

Locations: 🇺🇸
Augusta University Medical Center, Augusta, Georgia, United States
🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸
USA Health Strada Patient Care Center, Mobile, Alabama, United States

and more 250 locations

A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for Primary Central Nervous System Tumors

Phase 3

Recruiting

Conditions: Central Nervous System Carcinoma

Interventions: Procedure: Biospecimen Collection
Procedure: Cognitive Assessment
Procedure: Magnetic Resonance Imaging
Drug: Memantine Hydrochloride
Drug: Placebo Administration
Other: Questionnaire Administration

First Posted Date: 2021-06-25

Last Posted Date: 2024-12-04

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 192

Registration Number: NCT04939597

Locations: 🇺🇸
UCSF Benioff Children's Hospital Oakland, Oakland, California, United States
🇺🇸
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida, United States
🇺🇸
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia, United States

and more 132 locations

Financial Distress During Treatment for Pediatric Acute Lymphoblastic Leukemia in the United States

Active, not recruiting

Conditions: Acute Lymphoblastic Leukemia

Interventions: Other: Electronic Health Record Review
Other: Interview
Other: Survey Administration

First Posted Date: 2021-06-16

Last Posted Date: 2024-10-22

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 100

Registration Number: NCT04928599

Locations: 🇺🇸
Sunrise Hospital and Medical Center, Las Vegas, Nevada, United States
🇺🇸
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada, United States
🇺🇸
Summerlin Hospital Medical Center, Las Vegas, Nevada, United States

and more 38 locations

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Phase 1

Recruiting

Conditions: Diffuse Midline Glioma, H3 K27M-Mutant
Recurrent Diffuse Intrinsic Pontine Glioma
Metastatic Malignant Neoplasm in the Central Nervous System
Recurrent Osteosarcoma
Refractory Malignant Solid Neoplasm
Refractory Primary Malignant Central Nervous System Neoplasm
Recurrent Lymphoma
Recurrent Primary Malignant Central Nervous System Neoplasm
Refractory Osteosarcoma
Refractory Lymphoma

Interventions: Procedure: Biospecimen Collection
Procedure: Bone Marrow Aspirate
Procedure: Bone Marrow Biopsy
Procedure: Echocardiography
Drug: FACT Complex-targeting Curaxin CBL0137

First Posted Date: 2021-05-04

Last Posted Date: 2024-12-04

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 95

Registration Number: NCT04870944

Locations: 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸
Children's Hospital of Orange County, Orange, California, United States

and more 29 locations

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