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Children's Oncology Group

πŸ‡ΊπŸ‡ΈUnited States
Ownership
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Employees
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Market Cap
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Website

Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Phase 3
Active, not recruiting
Conditions
Mixed Phenotype Acute Leukemia
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Acute Lymphoblastic Leukemia
Interventions
Procedure: Biospecimen Collection
Procedure: Bone Marrow Aspiration
Procedure: Echocardiography Test
Procedure: Haploidentical Hematopoietic Cell Transplantation
Procedure: Lumbar Puncture
Procedure: Matched Unrelated Donor Hematopoietic Cell Transplantation
Procedure: Multigated Acquisition Scan
Procedure: Myeloablative Conditioning
Other: Quality-of-Life Assessment
Other: Questionnaire Administration
Radiation: Total-Body Irradiation
Procedure: T-Cell Depletion Therapy
First Posted Date
2022-07-14
Last Posted Date
2025-05-08
Lead Sponsor
Children's Oncology Group
Target Recruit Count
435
Registration Number
NCT05457556
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

Phoenix Childrens Hospital, Phoenix, Arizona, United States

πŸ‡ΊπŸ‡Έ

Arkansas Children's Hospital, Little Rock, Arkansas, United States

and more 60 locations

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Phase 3
Recruiting
Conditions
Childhood Medulloblastoma
Interventions
Procedure: Audiometric Test
Procedure: Auditory Brainstem Response
Procedure: Biospecimen Collection
Procedure: Magnetic Resonance Imaging
Other: Quality-of-Life Assessment
Radiation: Radiation Therapy
Other: Survey Administration
First Posted Date
2022-05-19
Last Posted Date
2025-06-11
Lead Sponsor
Children's Oncology Group
Target Recruit Count
225
Registration Number
NCT05382338
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

USA Health Strada Patient Care Center, Mobile, Alabama, United States

πŸ‡ΊπŸ‡Έ

Phoenix Childrens Hospital, Phoenix, Arizona, United States

and more 75 locations

Vincristine Pharmacokinetics in Infants

Recruiting
Conditions
Hematopoietic and Lymphoid Cell Neoplasm
Malignant Solid Neoplasm
Interventions
Procedure: Biospecimen Collection
First Posted Date
2022-05-03
Last Posted Date
2024-12-04
Lead Sponsor
Children's Oncology Group
Target Recruit Count
83
Registration Number
NCT05359237
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

Children's Hospital Los Angeles, Los Angeles, California, United States

πŸ‡ΊπŸ‡Έ

Children's Hospital of Orange County, Orange, California, United States

and more 26 locations

A Study of the Drug IMGN632 in Children With Leukemia That Has Come Back After Treatment or is Difficult to Treat

Phase 1
Withdrawn
Conditions
Recurrent Acute Myeloid Leukemia
Recurrent Mixed Phenotype Acute Leukemia
Refractory T Acute Lymphoblastic Leukemia
Refractory Acute Myeloid Leukemia
Recurrent T Acute Lymphoblastic Leukemia
Recurrent B Acute Lymphoblastic Leukemia
Refractory B Acute Lymphoblastic Leukemia
Refractory Mixed Phenotype Acute Leukemia
Interventions
First Posted Date
2022-04-11
Last Posted Date
2023-09-01
Lead Sponsor
Children's Oncology Group
Registration Number
NCT05320380

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

Phase 3
Recruiting
Conditions
Embryonal Rhabdomyosarcoma
Fusion-Negative Alveolar Rhabdomyosarcoma
Spindle Cell/Sclerosing Rhabdomyosarcoma
Interventions
Procedure: Biopsy
Procedure: Bone Scan
Procedure: Computed Tomography
Procedure: Magnetic Resonance Elastography
Procedure: Positron Emission Tomography
Radiation: Radiation Therapy
First Posted Date
2022-03-31
Last Posted Date
2025-06-10
Lead Sponsor
Children's Oncology Group
Target Recruit Count
205
Registration Number
NCT05304585
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

USA Health Strada Patient Care Center, Mobile, Alabama, United States

πŸ‡ΊπŸ‡Έ

Phoenix Childrens Hospital, Phoenix, Arizona, United States

and more 168 locations

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Phase 3
Recruiting
Conditions
Metastatic Malignant Neoplasm in the Lung
Osteosarcoma
Metastatic Osteosarcoma
Interventions
Procedure: Biospecimen Collection
Procedure: Computed Tomography
Other: Questionnaire Administration
Procedure: Thoracoscopy
Procedure: Thoracotomy
First Posted Date
2022-02-11
Last Posted Date
2025-06-10
Lead Sponsor
Children's Oncology Group
Target Recruit Count
250
Registration Number
NCT05235165
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

Providence Alaska Medical Center, Anchorage, Alaska, United States

πŸ‡ΊπŸ‡Έ

Kingman Regional Medical Center, Kingman, Arizona, United States

and more 228 locations

Evaluation of Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer

Active, not recruiting
Conditions
Malignant Solid Neoplasm
Hematopoietic and Lymphatic System Neoplasm
COVID-19 Infection
Interventions
Procedure: Biospecimen Collection
Other: Survey Administration
First Posted Date
2022-02-08
Last Posted Date
2025-04-03
Lead Sponsor
Children's Oncology Group
Target Recruit Count
549
Registration Number
NCT05228275
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

Kingman Regional Medical Center, Kingman, Arizona, United States

πŸ‡ΊπŸ‡Έ

UCSF Benioff Children's Hospital Oakland, Oakland, California, United States

and more 69 locations

Genetic Overlap Between Anomalies and Cancer in Kids in the Children's Oncology Group: The COG GOBACK Study

Recruiting
Conditions
Congenital Anomaly
Pediatric Cancer
Interventions
Other: Whole Genome Sequencing
Other: Questionnaire Administration
Other: Biospecimen collection
Other: Laboratory Biomarker Analysis
First Posted Date
2021-10-08
Last Posted Date
2024-12-20
Lead Sponsor
Children's Oncology Group
Target Recruit Count
1000
Registration Number
NCT05071859
Locations
πŸ‡ΊπŸ‡Έ

Baylor College of Medicine/ Dan L Duncan Comprehensive Cancer Center, Houston, Texas, United States

Pilot Study to Enable Electronic Laboratory Data Transfer From Participating Institutions to MediData/RAVE

Active, not recruiting
Conditions
Accurate and Complete Data Acquisition for Clinical Trials
Interventions
Other: Medidata RAVE
First Posted Date
2021-08-25
Last Posted Date
2024-11-25
Lead Sponsor
Children's Oncology Group
Target Recruit Count
118
Registration Number
NCT05020951
Locations
πŸ‡ΊπŸ‡Έ

UCSF Medical Center-Mission Bay, San Francisco, California, United States

πŸ‡ΊπŸ‡Έ

Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia, United States

πŸ‡ΊπŸ‡Έ

Children's Healthcare of Atlanta, Atlanta, Georgia, United States

and more 5 locations

Backtracking Leukemia-Typical Somatic Mutations in Cord Blood

Recruiting
Conditions
Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
Interventions
Other: Cord blood Sample Collection
Other: Case identification and recruitment
Other: Questionnaire Administration
First Posted Date
2021-08-20
Last Posted Date
2025-03-10
Lead Sponsor
Children's Oncology Group
Target Recruit Count
300
Registration Number
NCT05014165
Locations
πŸ‡ΊπŸ‡Έ

University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota, United States

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