Pharmacological modulation of heterosynaptic LOng-TErm POtentiation in humans by LOrazepam and METHylphenidat

Completed

Conditions: Hyperalgesic pain
Signs and Symptoms

Registration Number: ISRCTN88124420

Lead Sponsor: Individual sponsor (Germany)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 18

Inclusion Criteria

1. Healthy volunteers of full age
2. Subject familiarized with the experimental procedure prior to experimentation and had given written informed consent
3. At least a 50% increase of pain to pinprick stimuli and a 25% increase of pain to electrical stimuli following high-frequency electrical stimulation in a screening visit

Exclusion Criteria

1. Skin lesions at the test and/or control site
2. Use of any medication within one day prior to study onset except contraceptives
3. Known hypersensitivity to histamine or methylphenidate and lorazepam and their derivates
4. Any history of allergy or drug hypersensitivity
5. Chronic use of analgesics or Central Nervous System (CNS) active drugs
6. Pregnancy or nursing
7. Any acute or chronic disease

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The following outcomes will be assessed based on the sensory changes determined by QST during the intervention: <br>1. Spread of the area of dynamic allodynia and static hyperalgesia <br>2. Combined analgesic and anti-hyperalgesic effect to mechanical and electrical stimuli on the site of conditioning stimulation

Secondary Outcome Measures

Name	Time	Method
The following outcomes will be assessed based on the sensory changes determined by QST during the intervention:<br>1. Anti-hyperalgesic effect to electrical and mechanical test stimuli <br>2. Analgesic effect to electrical and mechanical test stimuli <br>3. Anti-wind up pain, tested by mechanical pinprick stimuli