The genomics of taste receptors in the prevention of obesity

• Conditions: obesity; Diet and Nutrition - Obesity

• Registration Number: ACTRN12611000058976
• Lead Sponsor: Dr Conor Delahunty

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-01-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

For these studies, we are specifically seeking individuals who are:

- 18 years or older
- Living in metropolitan Sydney
- Proficient in both written and spoken English
- Able to attend testing sessions between the hours of 9:00 am - 5:00pm Monday to Friday

Exclusion Criteria

For these studies we are specifically excluding individuals based upon the following criteria:

- Adults with known medical conditions known to affect weight (hyperthyroidism, Cushing syndrome etc)
- Individuals who are currently on, or have been on a diet, or specific dietary routine within the past 3 months
- Individuals who have experienced fluctuations in their weight by > 3 kg in the past 3 months
- Individuals who do not have adequate taste function
- Individuals who are restrained eaters (as defined by a score of > 12 on factor one of the eating attitudes test
- Individuals who are allergic to, or do not wish to consume dairy products
- Individuals over the age of 55 years
-Smokers

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome will be taste sensitivity, as measured by detection and difference thresholds for sweet, fatty acid, salty, sour, umami and bitter tastes. Detection thresholds are considered the lowest amount of a tastant required for it to be detected, whereas difference thresholds are the concentration of tastant required for it be tasted as different from another sample at suprathreshold (above detection threshold) concentrations.[Taste thresholds, both detection and difference thresholds for these tastants will be measured in duplicate. Detection and difference thresholds will be measured on seperated occasions, seperated by 24 hours.]