Risk Factors Related to Postoperative Acute Kidney Injury in Elderly Patients Undergoing Joint Replacement
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- Incidence and outcome of AKI after joint replacement
研究概览
简要总结
Total hip arthroplasty refers to the replacement of the femoral head and acetabulum damaged by disease or trauma with an artificial hip joint, thereby restoring joint activity and original function. Acute kidney injury is a common complication after total hip arthroplasty. Previous studies have shown that the incidence of acute kidney injury after hip replacement is as high as 21.9%. Acute kidney injury has become a global safety issue, and the occurrence of acute kidney injury can lead to an increase in hospital stay, medical costs and increased risk of death.There is currently no global survey of the incidence of AKI, and only a number of studies have been conducted on specific patient groups (eg, inpatients, intensive care units [ICU] patients or children) due to differences in study design and definition of acute kidney injury.
详细描述
The incidence and prevalence of different studies vary widely, ranging from 0.32% to 44.30%. There are few studies on the risk factors associated with acute kidney injury after total hip arthroplasty, and early acute kidney injury is often overlooked due to the limitations of the current KDIGO-based diagnostic method. Therefore, it is particularly important for clinicians to understand the risk factors for postoperative acute kidney injury .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients age 65 or older
- •One-sided joint replacement;
- •ASA score grade I-III
排除标准
- •Emergency surgery patients;
- •Patients with severe liver and kidney dysfunction;
- •Missing related data;
- •Serious systemic diseases before surgery;
结局指标
主要结局
Incidence and outcome of AKI after joint replacement
时间窗: Within 7 days after surgery
AKI can be diagnosed if one of the following conditions is true: (1) Serum creatinine increases by ≥26.5 μmol/L (0.3 mg / dl) within 48 h; (2)Serum creatinine rises more than 1.5 times of the baseline value, and is significantly or presumably the above situation occurred within 7 days;
次要结局
- Possible risk factors for AKI after joint replacement(1 day before surgery)
- Factors related to anesthesia(during sugery and within 7days after sugery)
- Intraoperative fluid volume and infusion type(during sugery and within 7days after surgery)
- Hemodynamic changes(during sugery and within 7days after sugery)
研究者
Jin Dong Liu
The Affiliated Hospital of Xuzhou Medical University
Xuzhou Medical University