Risk Factors Related to Postoperative Acute Kidney Injury in Elderly Patients Undergoing Joint Replacement

• Conditions: Acute Kidney Injury

• Registration Number: NCT04132921
• Lead Sponsor: Xuzhou Medical University

Brief Summary

Total hip arthroplasty refers to the replacement of the femoral head and acetabulum damaged by disease or trauma with an artificial hip joint, thereby restoring joint activity and original function. Acute kidney injury is a common complication after total hip arthroplasty. Previous studies have shown that the incidence of acute kidney injury after hip replacement is as high as 21.9%. Acute kidney injury has become a global safety issue, and the occurrence of acute kidney injury can lead to an increase in hospital stay, medical costs and increased risk of death.There is currently no global survey of the incidence of AKI, and only a number of studies have been conducted on specific patient groups (eg, inpatients, intensive care units \[ICU\] patients or children) due to differences in study design and definition of acute kidney injury.

Detailed Description

The incidence and prevalence of different studies vary widely, ranging from 0.32% to 44.30%. There are few studies on the risk factors associated with acute kidney injury after total hip arthroplasty, and early acute kidney injury is often overlooked due to the limitations of the current KDIGO-based diagnostic method. Therefore, it is particularly important for clinicians to understand the risk factors for postoperative acute kidney injury .

Study Timeline

• Status Verified: 2019-10
• Study First Submitted: 2019-10-11
• Study First Submitted QC: 2019-10-16
• Study First Posted: 2019-10-21
• Study Start: 2019-10-25
• Primary Completion: 2020-06-01
• Last Update Submitted: 2020-08-10
• Last Update Posted: 2020-08-11
• Study Completion: 2020-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

• Patients age 65 or older
• One-sided joint replacement;
• ASA score grade I-III

Exclusion Criteria

• Emergency surgery patients;
• Patients with severe liver and kidney dysfunction;
• Missing related data;
• Serious systemic diseases before surgery;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence and outcome of AKI after joint replacement	Within 7 days after surgery	AKI can be diagnosed if one of the following conditions is true: (1) Serum creatinine increases by ≥26.5 μmol/L (0.3 mg / dl) within 48 h; (2)Serum creatinine rises more than 1.5 times of the baseline value, and is significantly or presumably the above situation occurred within 7 days;

Secondary Outcome Measures

Name	Time	Method
Possible risk factors for AKI after joint replacement	1 day before surgery	Patient's age, gender, height, weight
Factors related to anesthesia	during sugery and within 7days after sugery	Record the type and dose of anesthetic used in the procedure
Intraoperative fluid volume and infusion type	during sugery and within 7days after surgery	Record the total amount of infusion and infusion type of during surgery
Hemodynamic changes	during sugery and within 7days after sugery	Focus on the fluctuation of mean arterial pressure

Trial Locations

Locations (1)

The Affiliated Hospital of Xuzhou Medical University; 🇨🇳 Xuzhou, Jiangsu, China