To Assess The Effectiveness Of Injectable Platelet Rich Fibrin In Increasing Gingival Thickness

Phase 1/2

Not yet recruiting

Conditions: Chronic gingivitis,

Registration Number: CTRI/2021/04/032650

Lead Sponsor: Manasa Budhan

Brief Summary: Gingival biotype is the quality of soft tissue profile surrounding the tooth.Base on gingival thickness(Aimetti et al classification,2008), gingival biotype can be thin gingival biotype(<1mm) and thick gingival biotype(>1mm).Gingival biotype is important for periodontal health,aesthetics and function,and is a predictor of periodontal and peri-implant treatments.Thin gingval biotype can lead to gingival recession as a result of traumatic brushing,orthodontic,restorative and periodontal treatment.Thin gingival biotype also lead to unpredictable post-operative soft tissue healing,graft failure and extensive bone resorption after tooth extraction.Gingival thickness can be enhanced by different methods.Connective tissue graft is the gold standard procedure, but it requires second surgical site and there is limited availability of tissue.Alternative options are acellular dermal matrix and use of platelet concentrates like Platelet rich Plasma (PRP) and Platelet rich Fibrin (PRF). Injectable Platelet rich Fibrin(i-PRF) is a modification of PRF developed in 2014 by lowering spin centrifugation forces in non-glass centrifugation tubes.Studies have reported enhanced gingival thickness with PRP and conventional PRF.The present study is to evaluate the gingival thickness after injection with i-PRF in healthy volunteers with thin gingival biotype.

**PROCEDURE: 0.2ml**i-PRF will be injected at 6 points of central and lateral incisors on the test side.Contralateral side will be kept as control without i-PRF injection.Gingival thickness will be measured on the day of procedure before injection(baseline),at 3 months and 6 months follow up using a digital vernier calliper.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

Healthy volunteers Volunteers with thin gingival biotype according to aimetti et al classification 2008 (ï‚£ 1mm thin; ï‚³ 1mm thick) in all maxillary incisors and/or mandibular incisors. Non.
smokers. Periodontally and systemically healthy. Good oral hygiene.

Exclusion Criteria

Individual with insufficient platelet count(<200,000/cubic mm) Pregnant and lactating women Individuals undergoing orthodontic therapy Presence of restorations in selected teeth.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gingival thickness	At the day of procedure before injection(baseline) after 3 months and after 6 months

Secondary Outcome Measures

Name	Time	Method
Width of keratinized gingiva	At the day of procedure before injection(baseline) after 3 months and after 6 months

Trial Locations

Locations (1): Pms college of dental science and research
🇮🇳
Thiruvananthapuram, KERALA, India
Pms college of dental science and research
🇮🇳Thiruvananthapuram, KERALA, India
Manasa Budhan
Principal investigator
7306028359
manasabudhan59@gmail.com