Ivabradine Versus Propranolol for Induced Hypotension in Endoscopic Sinus Surgery

Phase 2

• Conditions: Hypotension
• Interventions: Drug: oral Ivabradine; Drug: oral Propranolol

• Registration Number: NCT04580342
• Lead Sponsor: Ahmed talaat ahmed aly

Brief Summary

the study is designed to compare the effect of addition of oral Ivabradine, propranolol to general anesthesia aimed reduction in blood loss during functional endoscopic sinus surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-09-30
• Status Verified: 2020-10
• Study First Submitted QC: 2020-10-06
• Study First Posted: 2020-10-08
• Last Update Submitted: 2020-10-12
• Last Update Posted: 2020-10-14
• Study Start: 2020-10-15
• Primary Completion: 2021-01-01
• Study Completion: 2021-01-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age of 18 - 60 years.
• Patients of both genders.
• ASA grade I - II .

Exclusion Criteria

• Patient refusal.
• Any contraindication to medication included in the study .
• Patients with allergy to medication included in the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ivabradine group	oral Ivabradine	-
propranolol group	oral Propranolol	-

Primary Outcome Measures

Name	Time	Method
change in blood loss	immediately after the surgery	Estimated blood loss in millilitres per hour is calculated by subtracting the volume of total irrigation used during the case from the total amount of fluid in the suction canister at the end of surgery in addition, pre-weighing and post-weighing of sponges and oropharyngeal packs were also done and dividing by surgical time in hours.; assessment of blood loss by Boezaart and van der Merwe Grading System for bleeding during Endoscopic Sinus Surgery

Trial Locations

Locations (1)

Ahmed Talaat Ahmed; 🇪🇬 Assiut, Egypt