Ketamine

Generic Name
Ketamine
Brand Names
Ketalar
Drug Type
Small Molecule
Chemical Formula
C13H16ClNO
CAS Number
6740-88-1
Unique Ingredient Identifier
690G0D6V8H
Background

Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic effects and shorter psychotomimetic eff...

Indication

Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior oth...

Associated Conditions
-
Associated Therapies
General Anesthesia, Induction and Maintenance of General Anesthesia
Clinical Trials
Related News

Low-Dose Ketamine Infusion for Children With Sickle Cell Disease-Related Pain

Phase 2
Terminated
Conditions
Sickle Cell Disease
Interventions
Drug: ketamine
First Posted Date
2008-01-16
Last Posted Date
2019-08-21
Lead Sponsor
Connecticut Children's Medical Center
Target Recruit Count
3
Registration Number
NCT00595530
Locations
🇺🇸

University of Connecticut Health Center, Farmington, Connecticut, United States

🇺🇸

Connecticut Children's Medical Center, Hartford, Connecticut, United States

Low Dose Ketamine as an Adjunct to Fentanyl in Outpatient Tonsillectomy

Not Applicable
Completed
Conditions
Pain
Interventions
Drug: Placebo
Drug: ketamine
First Posted Date
2008-01-07
Last Posted Date
2017-06-14
Lead Sponsor
Mayo Clinic
Target Recruit Count
122
Registration Number
NCT00587665
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS

First Posted Date
2007-12-21
Last Posted Date
2010-06-17
Lead Sponsor
Drexel University College of Medicine
Target Recruit Count
40
Registration Number
NCT00579085
Locations
🇺🇸

Drexel University College of Medicine Department of Neurology, Philadelphia, Pennsylvania, United States

Efficacy of Ketamine in Children With Severe Brain Injury for Brain Cell Protection

Phase 2
Withdrawn
Conditions
Traumatic Brain Injury
Interventions
Drug: saline
Drug: Ketamine
First Posted Date
2007-11-12
Last Posted Date
2013-11-01
Lead Sponsor
University of Arkansas
Registration Number
NCT00556387

Use of Ketamine Prior to Cardiopulmonary Bypass in Children

Phase 2
Completed
Conditions
Ventricular Septal Defect
Interventions
Drug: saline
Drug: ketamine
First Posted Date
2007-11-12
Last Posted Date
2007-11-12
Lead Sponsor
Arkansas Children's Hospital Research Institute
Target Recruit Count
24
Registration Number
NCT00556361
Locations
🇺🇸

Arkansas Children's Hospital, Little Rock, Arkansas, United States

Continuation Ketamine in Major Depression

Phase 1
Completed
Conditions
Major Depressive Disorder
Interventions
Drug: Lithium
Drug: Ketamine
First Posted Date
2007-10-25
Last Posted Date
2014-05-23
Lead Sponsor
James Murrough
Target Recruit Count
36
Registration Number
NCT00548964
Locations
🇺🇸

Icahn School of Medicine at Mount Sinai, New York, New York, United States

Ketamine In Thoracic Surgery (KITS) Trial

Phase 2
Completed
Conditions
Lung Cancer
Interventions
Drug: 0.9% saline
Drug: Ketamine
First Posted Date
2007-07-20
Last Posted Date
2014-07-25
Lead Sponsor
Duke University
Target Recruit Count
40
Registration Number
NCT00504725
Locations
🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?

First Posted Date
2007-06-15
Last Posted Date
2014-04-14
Lead Sponsor
Northwestern University
Target Recruit Count
188
Registration Number
NCT00486902
Locations
🇺🇸

Northwestern University, Chicago, Illinois, United States

Ketamine Associated With Opioids in Refractory Cancer Pain Treatment

Phase 3
Completed
Conditions
Pain
Interventions
Drug: Ketamine
First Posted Date
2007-06-11
Last Posted Date
2011-05-04
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
100
Registration Number
NCT00484484
Locations
🇫🇷

Hopital Saint Antoine, Paris, France

Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity

Phase 4
Completed
Conditions
Intubation; Difficult
Interventions
Drug: Ketamine
Drug: Etomidate
First Posted Date
2007-02-26
Last Posted Date
2011-09-22
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
655
Registration Number
NCT00440102
Locations
🇫🇷

Chu Avicenne, Bobigny, France

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