Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

The Effect of General Anesthesia on the Middle Ear Pressure

Not Applicable

Completed

Conditions: Ear Deformities, Acquired

Interventions: Drug: desflurane,
Drug: Sevoflurane

First Posted Date: 2017-04-04

Last Posted Date: 2017-04-11

Lead Sponsor: Trakya University

Target Recruit Count: 50

Registration Number: NCT03100604

Heart Rate Variability Under Propofol and Sevoflurane

Not Applicable

Completed

Conditions: General Anesthesia

Interventions: Drug: Sevoflurane
Drug: Propofol
Drug: Remifentanil

First Posted Date: 2017-04-04

Last Posted Date: 2017-04-04

Lead Sponsor: Hôpital Armand Trousseau

Target Recruit Count: 40

Registration Number: NCT03098875

Locations: 🇫🇷
Departement d'anesthesie Hopital Armand Trousseau, Paris, France

A Study to Compare the Long-term Outcomes After Two Different Anaesthetics

Phase 3

Active, not recruiting

Conditions: Anesthesia
Child Development
Neurotoxicity

Interventions: Drug: Sevoflurane
Drug: Remifentanil
Drug: Dexmedetomidine

First Posted Date: 2017-03-24

Last Posted Date: 2024-07-05

Lead Sponsor: Murdoch Childrens Research Institute

Target Recruit Count: 450

Registration Number: NCT03089905

Locations: 🇺🇸
Boston Children's Hospital, Boston, Massachusetts, United States
🇺🇸
The University of Texas Southwestern Medical Center, Dallas, Texas, United States
🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

and more 18 locations

Effect of Total Intravenous Anaesthesia With Propofol on Postoperative Pain After Bilateral Third Molar Surgery

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Sevoflurane
Drug: propofol

First Posted Date: 2017-02-20

Last Posted Date: 2020-07-07

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 96

Registration Number: NCT03058341

Locations: 🇭🇰
The University of Hong Kong, Hong Kong, Hong Kong

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair

Not Applicable

Conditions: Hernia, Inguinal
Pain, Postoperative

Interventions: Procedure: Caudal-epidural nerve block
Procedure: Ilioinguinal/iliohypogastric nerve block
Drug: Acetaminophen
Drug: Sevoflurane
Drug: Remifentanil
Drug: Propofol
Drug: Morphine
Drug: Ondansetron
Drug: Dexamethasone
Drug: Ketorolac

First Posted Date: 2017-02-03

Last Posted Date: 2017-11-14

Lead Sponsor: Alberta Children's Hospital

Target Recruit Count: 88

Registration Number: NCT03041948

Locations: 🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada
🇨🇦
Royal University Hospital/University of Saskatchewan, Saskatoon, Saskatchewan, Canada