Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

Not Applicable

Completed

Conditions: Complications
Anesthesia
Urinary Bladder Neoplasms
Catheter Site Discomfort

Interventions: Drug: Sevoflurane
Drug: Desflurane

First Posted Date: 2014-03-26

Last Posted Date: 2014-10-02

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 108

Registration Number: NCT02096224

Locations: 🇰🇷
Seoul National University of Hospital, Seoul, Korea, Republic of

The Effect of Sevoflurane on Cerebral CO2 Sensitivity and Systemic Arteries

Phase 4

Completed

Conditions: Sevoflurane Anesthesia

Interventions: Procedure: Partial pressure of CO2 at the end of an exhaled breath
Drug: Sevoflurane

First Posted Date: 2014-02-04

Last Posted Date: 2014-02-04

Lead Sponsor: University of Debrecen

Target Recruit Count: 24

Registration Number: NCT02054143

Locations: 🇭🇺
University of Debrecen Medical and Health Science Center Department of Anesthesiology and Intensive Care, Debrecen, Hungary

Anesthesia in Patients With Mitochondrial Disease

Not Applicable

Terminated

Conditions: Mitochondrial Diseases

Interventions: Drug: Sevoflurane
Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2014-02-04

Last Posted Date: 2024-08-28

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 19

Registration Number: NCT02053766

Locations: 🇺🇸
University of Texas Health Science Center at Houston, Houston, Texas, United States

Anesthesia and Circulating Tumor Cells in Breast Cancer

Phase 4

Completed

Conditions: Female Breast Carcinoma

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2013-12-09

Last Posted Date: 2020-04-14

Lead Sponsor: University of Zurich

Target Recruit Count: 221

Registration Number: NCT02005770

Locations: 🇨🇭
Institute of Physicians for Anesthesia and Intensive Care Klinik Hirslanden, Zurich, Switzerland
🇨🇭
University Hospital Zurich, Institute of Anesthesiology, Zurich, ZH, Switzerland

Prothrombotic Factors and Anaesthesia in Prostate Cancer

Not Applicable

Completed

Conditions: Surgery
Prostatic Cancer

Interventions: Drug: Midazolam
Drug: Propofol
Drug: Fentanyl
Drug: remifentanyl
Drug: Sevoflurane

First Posted Date: 2013-12-02

Last Posted Date: 2014-11-06

Lead Sponsor: Regina Elena Cancer Institute

Target Recruit Count: 200

Registration Number: NCT01998685

Locations: 🇮🇹
Department of Anaesthesiology, Regina Elena, National Cancer Institute, Roma, Italy

Sevoflurane and Propofol Anesthesia on Postoperative Delirium

Phase 4

Conditions: General Anesthesia
Geriatric Patient

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2013-11-26

Last Posted Date: 2013-11-26

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 500

Registration Number: NCT01995214

Locations: 🇨🇳
Tongji Hospital, Wuhan, Hubei, China

Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia

Phase 4

Completed

Conditions: Breast Neoplasms
Colonic Neoplasms
Rectal Neoplasms

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2013-11-03

Last Posted Date: 2022-12-14

Lead Sponsor: Uppsala University

Target Recruit Count: 5774

Registration Number: NCT01975064

Locations: 🇵🇱
Wroclaw Medical University, Wroclaw, Poland
🇨🇳
Fourth Military Medical University Hospital, Xijing, China
🇸🇪
Skane University Hospital, Lund, Lund, Sweden

and more 12 locations