Ganciclovir
- Generic Name
- Ganciclovir
- Brand Names
- Cytovene, Zirgan
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13N5O4
- CAS Number
- 82410-32-0
- Unique Ingredient Identifier
- P9G3CKZ4P5
- Background
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
- Indication
For induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised pat...
- Associated Conditions
- CMV colitis, Cytomegalovirus (CMV) Infections, Cytomegalovirus Retinitis, Cytomegalovirus gastroesophagitis, Varicella-zoster Progressive outer retinal necrosis, Acute Herpetic keratitis, Cytomegalovirus neurological disease, Varicella-zoster virus acute retinal necrosis
- Associated Therapies
- -
Measuring Changes in Blood in Patients at High Risk of Cytomegalovirus Infection After Undergoing Donor Bone Marrow Transplant or Peripheral Blood Stem Cell Transplant
- First Posted Date
- 2008-07-16
- Last Posted Date
- 2015-06-08
- Lead Sponsor
- City of Hope Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT00716911
Ganciclovir by Infusion and by Mouth in Treating Patients With Cytomegalovirus After Donor Bone Marrow Transplant
- Conditions
- Interventions
- First Posted Date
- 2007-09-17
- Last Posted Date
- 2017-12-02
- Lead Sponsor
- City of Hope Medical Center
- Target Recruit Count
- 61
- Registration Number
- NCT00530218
- Locations
- 🇺🇸
City of Hope National Medical Center, Duarte, California, United States
Maribavir Versus Oral Ganciclovir For The Prevention of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients
- First Posted Date
- 2007-07-09
- Last Posted Date
- 2021-06-11
- Lead Sponsor
- Shire
- Target Recruit Count
- 307
- Registration Number
- NCT00497796
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
🇺🇸Rush University Medical Center, Chicago, Illinois, United States
🇺🇸University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
VICTOR Study - A Study of Valcyte (Valganciclovir po) Compared to Ganciclovir iv in Patients With Cytomegalovirus (CMV) Disease Who Are Solid Organ Transplant Recipients
- Conditions
- Interventions
- First Posted Date
- 2007-02-05
- Last Posted Date
- 2016-11-02
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 325
- Registration Number
- NCT00431353
Prophylaxis With Ganciclovir Improves Graft Survival in Renal Allograft Recipients
- Conditions
- First Posted Date
- 2006-09-07
- Last Posted Date
- 2006-09-13
- Lead Sponsor
- Lower Saxony Center for Nephrology
- Target Recruit Count
- 150
- Registration Number
- NCT00373165
A Study of Valcyte (Valganciclovir) CMV Prophylaxis After Renal Transplantation
- Conditions
- Interventions
- First Posted Date
- 2006-09-06
- Last Posted Date
- 2020-03-11
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 299
- Registration Number
- NCT00372229
Trial of Preemptive Treatment With Oral Valganciclovir Compared With Intravenous (IV) Ganciclovir for Cytomegalovirus Infection After Bone Marrow or Peripheral Blood Stem Cell Transplant
- Conditions
- Interventions
- First Posted Date
- 2005-10-18
- Last Posted Date
- 2013-07-23
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 39
- Registration Number
- NCT00241345
- Locations
- 🇺🇸
Washington University School of Medicine, St. Louis, Missouri, United States
Bortezomib and Antiviral Therapy Followed By Effusion Drainage, Bevacizumab, and Combination Chemotherapy in Treating Patients With Primary Effusion Lymphoma
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2013-06-20
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 15
- Registration Number
- NCT00217503
- Locations
- 🇺🇸
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office, Bethesda, Maryland, United States
Steroid-Free Versus Steroid-Based Immunosuppression in Pediatric Renal (Kidney) Transplantation
- First Posted Date
- 2005-09-01
- Last Posted Date
- 2016-11-29
- Target Recruit Count
- 130
- Registration Number
- NCT00141037
- Locations
- 🇺🇸
UCLA - Department of Pediatrics, Division of Nephrology, Los Angeles, California, United States
🇺🇸Children's Hospital Boston - Division of Nephrology, Boston, Massachusetts, United States
🇺🇸Children's Hospital of New Orleans-Department of Pediatric Nephrology, New Orleans, Louisiana, United States
Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma
- Conditions
- First Posted Date
- 2004-08-09
- Last Posted Date
- 2015-04-29
- Lead Sponsor
- National Human Genome Research Institute (NHGRI)
- Registration Number
- NCT00005057
- Locations
- 🇺🇸
Baylor College of Medicine, Houston, Texas, United States
🇺🇸Clinical Genetherapy Branch, Bethesda, Maryland, United States
🇺🇸Metabolism Branch, Bethesda, Maryland, United States
Drug Development Updates
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