Ganciclovir

Generic Name
Ganciclovir
Brand Names
Cytovene, Zirgan
Drug Type
Small Molecule
Chemical Formula
C9H13N5O4
CAS Number
82410-32-0
Unique Ingredient Identifier
P9G3CKZ4P5
Background

An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

Indication

For induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised pat...

Associated Conditions
CMV colitis, Cytomegalovirus (CMV) Infections, Cytomegalovirus Retinitis, Cytomegalovirus gastroesophagitis, Varicella-zoster Progressive outer retinal necrosis, Acute Herpetic keratitis, Cytomegalovirus neurological disease, Varicella-zoster virus acute retinal necrosis
Associated Therapies
-

A Study of the Safety and Tolerance of Long-Term Therapy With Intravenous Cytovene (Ganciclovir Sodium) for Cytomegalovirus Retinitis in Persons With AIDS

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
100
Registration Number
NCT00002034
Locations
🇺🇸

Dr Alfred F Burnside Jr, Columbia, South Carolina, United States

🇺🇸

SUNY / Health Sciences Ctr at Stony Brook, Stony Brook, New York, United States

🇨🇦

Southern Alberta HIV Clinic / Foothills Hosp, Calgary, Alberta, Canada

and more 6 locations

A Randomized Study Comparing the Safety and Efficacy of Two Regimens of Oral Ganciclovir to Intravenous Ganciclovir Maintenance Therapy for Cytomegalovirus Retinitis in People With AIDS Who Have Received Prior Ganciclovir Therapy

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
225
Registration Number
NCT00002247
Locations
🇺🇸

Mount Zion Med Ctr, San Francisco, California, United States

🇺🇸

Dr Dorothy Friedberg, New York, New York, United States

🇺🇸

Georgetown Univ Med Ctr, Washington, District of Columbia, United States

and more 17 locations

A Multiple Dose Crossover Pharmacokinetics Study to Evaluate the Effects of Food on the Absorption of Oral Ganciclovir

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
20
Registration Number
NCT00002251
Locations
🇺🇸

Davies Med Ctr, San Francisco, California, United States

🇺🇸

Georgetown Univ Med Ctr, Washington, District of Columbia, United States

An Open-Label Safety Study of Oral Ganciclovir Maintenance Treatment of CMV Retinitis in People With Limited Venous Access

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Hoffmann-La Roche
Registration Number
NCT00002135
Locations
🇺🇸

Roche Global Development - Palo Alto, Palo Alto, California, United States

Ganciclovir: Compassionate Use in Patients With Serious or Life-Threatening Cytomegalovirus Infections

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Hoffmann-La Roche
Registration Number
NCT00002024
Locations
🇺🇸

Roche Global Development - Palo Alto, Palo Alto, California, United States

The Safety and Effectiveness of Ganciclovir Plus Interferon Beta in Preventing the Return of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Hoffmann-La Roche
Registration Number
NCT00002299
Locations
🇺🇸

UCI Med Ctr, Orange, California, United States

🇺🇸

Univ of California / San Diego Treatment Ctr, San Diego, California, United States

🇺🇸

USC, Los Angeles, California, United States

and more 3 locations

A Randomized, Double-Blind Study of the Efficacy and Safety of Oral Ganciclovir for the Prevention of CMV Disease in People Infected With the Human Immunodeficiency Virus

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
700
Registration Number
NCT00002095
Locations
🇺🇸

Kraus - Beer Med Group, Los Angeles, California, United States

🇺🇸

Beth Israel Hosp, Boston, Massachusetts, United States

🇺🇸

UCSD, San Diego, California, United States

and more 16 locations

Phase III Ganciclovir +/- rGM-CSF for AIDS-Related CMV Retinitis

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Schering-Plough
Registration Number
NCT00002070
Locations
🇺🇸

Children's Hosp of San Francisco, San Francisco, California, United States

🇺🇸

Pacific Presbyterian, San Francisco, California, United States

🇺🇸

Dr Douglas Dieterich, New York, New York, United States

and more 11 locations

An Open Label Evaluation of the Safety and Pharmacokinetics of Ganciclovir in Children

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Roche Global Development
Target Recruit Count
20
Registration Number
NCT00002015
Locations
🇺🇸

Univ of Rochester Med Ctr, Rochester, New York, United States

🇺🇸

Ctr for the Health Sciences / UCLA Med Ctr, Los Angeles, California, United States

🇺🇸

Univ of Chicago / Wylers, Chicago, Illinois, United States

and more 5 locations

A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR )

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Ionis Pharmaceuticals, Inc.
Target Recruit Count
194
Registration Number
NCT00002156
Locations
🇺🇸

Univ of Texas Southwestern Med Ctr of Dallas, Dallas, Texas, United States

🇺🇸

Retina - Vitreous Associates Med Group, Los Angeles, California, United States

🇺🇸

Univ of Illinois, Chicago, Illinois, United States

and more 15 locations
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