Oxytocin
- Generic Name
- Oxytocin
- Brand Names
- Pitocin
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 50-56-6
- Unique Ingredient Identifier
- 1JQS135EYN
- Background
Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recog...
- Indication
Administration of exogenous oxytocin is indicated in the antepartum period to initiate or improve uterine contractions for vaginal delivery in situations where there is fetal or maternal concern. For example, It may be used to induce labor in cases of Rh sensitization, maternal diabetes, preeclampsia at or near term, and when delivery is indicated due to pre...
- Associated Conditions
- Incomplete Abortion, Inevitable abortion, Postpartum Bleeding
- Associated Therapies
- Reinforcement of labor
Brain Blood Flow Changes Elicited by Oxytocin in Volunteers With and Without Schizophrenia
- First Posted Date
- 2010-05-14
- Last Posted Date
- 2019-08-19
- Lead Sponsor
- University of Maryland, Baltimore
- Registration Number
- NCT01123317
- Locations
- 🇺🇸
Maryland Psychiatric Research Center, Catonsville, Maryland, United States
Brain Imaging Study of Adults With Autism Spectrum Disorders
- Conditions
- First Posted Date
- 2010-03-26
- Last Posted Date
- 2019-12-17
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 38
- Registration Number
- NCT01093768
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Intraumbilical Vein Injection of Oxytocin in Routine Practice for Active Management of the Third Stage of Labor
- First Posted Date
- 2010-03-26
- Last Posted Date
- 2010-03-26
- Lead Sponsor
- Erzincan Military Hospital
- Target Recruit Count
- 412
- Registration Number
- NCT01094028
Oxytocin Buffers Stress Response in Individuals With Impaired Coping Abilities
- Conditions
- Interventions
- First Posted Date
- 2010-02-09
- Last Posted Date
- 2010-02-09
- Lead Sponsor
- University of Osnabrueck
- Registration Number
- NCT01065610
The Efficacy of a Single Dose of Intranasal Oxytocin in the Prevention of Post Traumatic Stress Disorder (PTSD)
- Conditions
- Interventions
- First Posted Date
- 2009-12-25
- Last Posted Date
- 2010-02-09
- Lead Sponsor
- Sheba Medical Center
- Target Recruit Count
- 24
- Registration Number
- NCT01039766
- Locations
- 🇮🇱
Sheba Medical Center, Ramat-Gan, Israel
Oxytocin or Galantamine Versus Placebo for the Treatment of Negative Symptoms and Cognitive Impairments in Schizophrenia
- Conditions
- Interventions
- First Posted Date
- 2009-11-11
- Last Posted Date
- 2022-01-12
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 86
- Registration Number
- NCT01012167
- Locations
- 🇺🇸
Baltimore VA Medical Center, Baltimore, Maryland, United States
🇺🇸Maryland Psychiatric Research Center, Catonsville, Maryland, United States
🇺🇸Community Mental Health Centers, Baltimore, Maryland, United States
Oxytocin Add-on Study for Stable Anxiety Patients
- First Posted Date
- 2009-10-06
- Last Posted Date
- 2019-09-25
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 17
- Registration Number
- NCT00989937
- Locations
- 🇺🇸
UCSD Medical Center, San Diego, California, United States
Impact of Uterotonic Agents on Isolated Human Myometrium
- Conditions
- Interventions
- First Posted Date
- 2009-10-02
- Last Posted Date
- 2014-02-20
- Target Recruit Count
- 56
- Registration Number
- NCT00989027
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Breast Stimulation Versus Pitocin for Induction of Labor
- Conditions
- Interventions
- First Posted Date
- 2009-09-25
- Last Posted Date
- 2009-09-25
- Lead Sponsor
- Hadassah Medical Organization
- Target Recruit Count
- 150
- Registration Number
- NCT00984347
- Locations
- 🇮🇱
Hadassah University Hospital Mt. Scopus, Jerusalem, Israel
Effect of Intranasal Oxytocin on Headache in Chronic Daily Headache
- Conditions
- Interventions
- First Posted Date
- 2009-08-20
- Last Posted Date
- 2023-06-15
- Lead Sponsor
- MedVadis Research Corporation
- Target Recruit Count
- 60
- Registration Number
- NCT00963040
- Locations
- 🇺🇸
MedVadis Research Corporation, Wellesley Hills, Massachusetts, United States
Drug Development Updates
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