Oxytocin

Generic Name: Oxytocin

Brand Names: Pitocin

Drug Type: Biotech

Chemical Formula: -

CAS Number: 50-56-6

Unique Ingredient Identifier: 1JQS135EYN

Background: Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recog...

Indication: Administration of exogenous oxytocin is indicated in the antepartum period to initiate or improve uterine contractions for vaginal delivery in situations where there is fetal or maternal concern. For example, It may be used to induce labor in cases of Rh sensitization, maternal diabetes, preeclampsia at or near term, and when delivery is indicated due to pre...

Associated Conditions: Incomplete Abortion, Inevitable abortion, Postpartum Bleeding

Associated Therapies: Reinforcement of labor

Clinical Trials

Effect of Intranasal Oxytocin on Appetite and Caloric Intake in Men and Women

Early Phase 1

Completed

Conditions: Eating Behavior

Interventions: Drug: Placebo
Drug: Oxytocin

First Posted Date: 2012-01-20

Last Posted Date: 2019-04-08

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 25

Registration Number: NCT01513499

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)

Not Applicable

Completed

Conditions: Posttraumatic Stress Disorder

Interventions: Drug: Placebo
Drug: Oxytocin

First Posted Date: 2011-11-06

Last Posted Date: 2017-04-14

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 60

Registration Number: NCT01466127

Locations: 🇺🇸
Center for Anxiety and Traumatic Disorders, MGH, Boston, Massachusetts, United States

Study of Oxytocin to Treat Vaginal Atrophy in Postmenopausal Women

Phase 2

Completed

Conditions: Postmenopause
Vaginal Atrophy

Interventions: Drug: Placebo
Drug: Oxytocin

First Posted Date: 2011-09-13

Last Posted Date: 2011-09-13

Lead Sponsor: PepTonic Medical AB

Target Recruit Count: 74

Registration Number: NCT01432470

Locations: 🇸🇪
Karolinska University Hospital-Huddinge, Huddinge, Sweden
🇸🇪
Uppsala University Hospital, Uppsala, Sweden
🇬🇧
Northwick Park & St Marks Hospital NHS Trust, Harrow Middlesex, United Kingdom

Control of Blood Loss During Caesarean Section

Phase 3

Completed

Conditions: Complications; Cesarean Section

Interventions: Drug: Misoprostol
Drug: oxytocin

First Posted Date: 2011-08-08

Last Posted Date: 2014-10-07

Lead Sponsor: Cairo University

Target Recruit Count: 600

Registration Number: NCT01412073

Locations: 🇪🇬
faculty of medicine , Cairo University, Cairo, Egypt

Accelerated Titration of Oxytocin for Nulliparous Patients With Labour Dystocia: ACTION Pilot Study

Phase 3

Terminated

Conditions: Labour Dystocia

Interventions: Drug: Oxytocin

First Posted Date: 2011-07-19

Last Posted Date: 2015-06-25

Lead Sponsor: Ottawa Hospital Research Institute

Target Recruit Count: 79

Registration Number: NCT01397630

Locations: 🇨🇦
Sainte-Justine Hospital, Montreal, Quebec, Canada
🇨🇦
The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Safety Study of Intranasal Oxytocin in Frontotemporal Dementia

Phase 1

Completed

Conditions: Frontotemporal Dementia

Interventions: Drug: oxytocin
Drug: Saline Nasal Mist

First Posted Date: 2011-07-01

Last Posted Date: 2013-11-03

Lead Sponsor: Lawson Health Research Institute

Target Recruit Count: 23

Registration Number: NCT01386333

Locations: 🇨🇦
Cognitive Neurology and Alzheimer Research Centre, London, Ontario, Canada

Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia

Phase 3

Conditions: Severe Preeclampsia
Postpartum Hemorrhage

Interventions: Drug: Carbetocin
Drug: Oxytocin

First Posted Date: 2011-06-27

Last Posted Date: 2015-01-05

Lead Sponsor: Saint Thomas Hospital, Panama

Target Recruit Count: 636

Registration Number: NCT01382732

Locations: 🇵🇦
Saint Thomas H, Panama, Panama

Prevention of Postpartum Haemorrhage With Sublingual Misoprostol or Oxytocin

Phase 3

Completed

Conditions: Postpartum Hemorrhage

Interventions: Drug: Misoprostol
Drug: Oxytocin

First Posted Date: 2011-06-14

Last Posted Date: 2011-06-14

Lead Sponsor: Jawaharlal Nehru Medical College

Target Recruit Count: 652

Registration Number: NCT01373359

Locations: 🇮🇳
Jawaharlal Nehru Medical College, Belgaum, Karnataka, India

Effect of Oxytocin on Stress in Marijuana Users

Not Applicable

Completed

Conditions: Marijuana Dependence

Interventions: Drug: Saline
Drug: Oxytocin

First Posted Date: 2011-04-14

Last Posted Date: 2015-12-14

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 16

Registration Number: NCT01335789

Locations: 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States

Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?

Not Applicable

Completed

Conditions: Schizophrenia

Interventions: Drug: Inactive placebo nasal spray
Drug: Oxytocin

First Posted Date: 2011-03-10

Last Posted Date: 2014-05-02

Lead Sponsor: VA Greater Los Angeles Healthcare System

Target Recruit Count: 24

Registration Number: NCT01312272

Locations: 🇺🇸
West Los Angeles VA Healthcare Center, Los Angeles, California, United States

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