Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Driving Performance After Deep Sedation for Outpatient Endoscopy

Phase 4

Completed

Conditions: Driving Impaired

Interventions: Procedure: No sedation
Drug: Propofol

First Posted Date: 2021-07-02

Last Posted Date: 2021-07-02

Lead Sponsor: University of Liege

Target Recruit Count: 60

Registration Number: NCT04948385

Locations: 🇧🇪
Centre hospitalier universitaire de Liege, Liège, Belgium

The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients

Phase 3

Conditions: Analgesia
Postoperative Pain

Interventions: Drug: Remimazolam Besylate
Drug: Propofol

First Posted Date: 2021-07-01

Last Posted Date: 2021-07-01

Lead Sponsor: Peking Union Medical College Hospital

Target Recruit Count: 84

Registration Number: NCT04947345

Pain Management of Pecto-intercostal Fascial Block Versus Intravenous Fentanyl After Pediatric Cardiac Surgery

Not Applicable

Conditions: Pediatric Patients
Congenital Heart Surgery

Interventions: Other: Ultrasound-guided bilateral pecto-intercostal fascial block
Drug: Intravenous fentanyl
Drug: Propofol
Drug: Sevoflurane
Drug: Atracurium
Device: ultrasound

First Posted Date: 2021-06-30

Last Posted Date: 2021-06-30

Lead Sponsor: Mansoura University

Target Recruit Count: 80

Registration Number: NCT04945694

Locations: 🇪🇬
Mansoura University, Mansoura, DK, Egypt

GUARDIAN (NCT04884802) Sub-study, Etomidate vs Propofol

Phase 3

Recruiting

Conditions: Major Surgery

Interventions: Procedure: Routine blood pressure control
Procedure: Tight blood pressure control
Drug: Etomidate
Drug: Propofol

First Posted Date: 2021-06-22

Last Posted Date: 2024-12-04

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 6254

Registration Number: NCT04934683

Locations: 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

Sedation Compaired With Anesthesia With THRIVE in Endotracheal Intubation With Difficult Airways

Not Applicable

Conditions: Sedative, Hypnotic, or Anxiolytic Withdrawal
Airway Control

Interventions: Device: Respiratory Humidification Treatment Device, AIRVO 2 PT101AZ, Fisher & Paykel Healthcare, Inc.
Device: Mask ventilation
Drug: Midazolam(T group)
Drug: Sufentanil(C group)
Drug: Sufentani(T group)
Drug: Midazolam(C group)
Drug: Propofol(T group)
Drug: Propofol
Drug: Rocuronium(T group)
Drug: Tetracaine(C group)
Drug: Drug use target(T group)
Drug: Drug use target

First Posted Date: 2021-06-14

Last Posted Date: 2022-04-12

Lead Sponsor: Peking University

Target Recruit Count: 42

Registration Number: NCT04924621

Locations: 🇨🇳
Peking University Hospital of Stomatology, Beijing, Beijing, China

The Effectiveness of Sedation and Analgesia in Colonoscopy Treatment of Colorectal Polyps

Not Applicable

Recruiting

Conditions: Sedation and Analgesia
Colonoscopy

Interventions: Drug: midazolam and dezocine
Drug: Propofol

First Posted Date: 2021-05-28

Last Posted Date: 2021-05-28

Lead Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University

Target Recruit Count: 340

Registration Number: NCT04906317

Locations: 🇨🇳
The Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

Dexmedetomidine-ketamine Versus Propofol-ketamine for Sedation During Endoscopy in Hepatic Patients

Phase 4

Completed

Conditions: Anesthesia; Reaction

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2021-05-28

Last Posted Date: 2024-01-31

Lead Sponsor: Tamer Nabil Abdelrahman

Target Recruit Count: 70

Registration Number: NCT04906772

Locations: 🇪🇬
Faculty of medicine, Ain-Shams university, Cairo, Egypt

Effect of Propfol Versus Sevoflurane on Auditory and Cognitive Function

Phase 4

Completed

Conditions: Cognitive Dysfunction
Auditory Dysfunction, Central

Interventions: Drug: Propofol

First Posted Date: 2021-05-05

Last Posted Date: 2022-05-06

Lead Sponsor: Beni-Suef University

Target Recruit Count: 80

Registration Number: NCT04874545

Locations: 🇪🇬
Beni-Suef University, Banī Suwayf, Egypt

Sedation for Patients Undergoing Endoscopic Retrograde Cholangiopancreatography

Not Applicable

Completed

Conditions: Biliary Colic

Interventions: Drug: Diclofenac Sodium and Lignocaine 10 % spray
Drug: Propofol

First Posted Date: 2021-04-26

Last Posted Date: 2021-04-26

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 90

Registration Number: NCT04860167

Locations: 🇮🇳
Gaurav Sindwani, New Delhi, Delhi, India

Hypersensitivity Reactions to Propofol in Children

Completed

Conditions: Hypersensitivity
Soy Allergy
Allergy, Egg

Interventions: Drug: Propofol

First Posted Date: 2021-04-09

Last Posted Date: 2023-05-11

Lead Sponsor: Universitair Ziekenhuis Brussel

Target Recruit Count: 2299

Registration Number: NCT04839666

Locations: 🇧🇪
UZ Brussel, Jette, Brussel, Belgium

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