Propofol
- Generic Name
- Propofol
- Brand Names
- Diprivan
- Drug Type
- Small Molecule
- Chemical Formula
- C12H18O
- CAS Number
- 2078-54-8
- Unique Ingredient Identifier
- YI7VU623SF
- Background
Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
- Indication
Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
- Associated Conditions
- -
- Associated Therapies
- Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery
- First Posted Date
- 2021-01-15
- Last Posted Date
- 2023-10-06
- Lead Sponsor
- Haisco-USA Pharmaceuticals, Inc.
- Target Recruit Count
- 255
- Registration Number
- NCT04711837
- Locations
- 🇺🇸
Lotus Clinical Research, LLC, Pasadena, California, United States
🇺🇸Phoenix Clinical Research, LLC, Tamarac, Florida, United States
🇺🇸Plano Surgical Hospital, Plano, Texas, United States
Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy
- First Posted Date
- 2020-12-31
- Last Posted Date
- 2020-12-31
- Lead Sponsor
- Tianjin Union Medical Center
- Target Recruit Count
- 1000
- Registration Number
- NCT04691076
- Locations
- 🇨🇳
Tianjin Union Medical Center, Tianjin, China
Desflurane and Brain Relaxation in Craniotomy
- First Posted Date
- 2020-12-31
- Last Posted Date
- 2021-10-26
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 111
- Registration Number
- NCT04691128
- Locations
- 🇨🇳
Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing, China
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I
- Conditions
- Interventions
- First Posted Date
- 2020-12-23
- Last Posted Date
- 2024-12-02
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 15
- Registration Number
- NCT04680910
- Locations
- 🇺🇸
Washington University School of Medicine/Barnes-Jewish Hospital, Saint Louis, Missouri, United States
A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation
- First Posted Date
- 2020-12-17
- Last Posted Date
- 2022-05-27
- Lead Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
- Target Recruit Count
- 20
- Registration Number
- NCT04669821
- Locations
- 🇨🇳
The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China
The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung
- Conditions
- Interventions
- First Posted Date
- 2020-11-27
- Last Posted Date
- 2021-11-12
- Lead Sponsor
- Inonu University
- Target Recruit Count
- 72
- Registration Number
- NCT04645316
- Locations
- 🇹🇷
Inonu University, Malatya, Turkey
A Study Evaluating Sedation of Intravenous Administration of HSK3486 Injectable Emulsion in ICU Patients Undergoing Mechanical Ventilation
- First Posted Date
- 2020-11-06
- Last Posted Date
- 2022-05-27
- Lead Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
- Target Recruit Count
- 135
- Registration Number
- NCT04620031
- Locations
- 🇨🇳
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Propofol Versus Sevoflurane During FESS
- First Posted Date
- 2020-11-06
- Last Posted Date
- 2020-11-06
- Lead Sponsor
- Algemeen Ziekenhuis Maria Middelares
- Target Recruit Count
- 60
- Registration Number
- NCT04619160
- Locations
- 🇧🇪
General Hospital Maria Middelares, Ghent, Oost-Vlaanderen, Belgium
Effects of TIVA Versus Inhalational Anaesthesia on Circulating Tumour Cells in Hepatocellular Carcinoma Patients
- Conditions
- Interventions
- First Posted Date
- 2020-10-26
- Last Posted Date
- 2023-03-31
- Lead Sponsor
- The University of Hong Kong
- Target Recruit Count
- 220
- Registration Number
- NCT04601961
- Locations
- 🇨🇳
HKU Li Ka Shing Faculty of Medicine, Hong Kong, Guangdong, China
NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane
- First Posted Date
- 2020-09-28
- Last Posted Date
- 2023-12-21
- Lead Sponsor
- Ciusss de L'Est de l'Île de Montréal
- Target Recruit Count
- 60
- Registration Number
- NCT04567160
- Locations
- 🇨🇦
CIUSSS de l'Est de l'Ile de Montreal, Montreal, Quebec, Canada
Drug Development Updates
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