Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

The Impact of Inhalation vs Total Intravenous Anesthesia on the Immune Status and Mortality in Patients Undergoing Breast Cancer Surgery: a Prospective Double-Blind Randomized Clinical Trial.

Not Applicable

Recruiting

Conditions: Anesthesia
Breast Cancer

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2021-03-16

Last Posted Date: 2023-04-26

Lead Sponsor: Moscow Clinical Scientific Center

Target Recruit Count: 130

Registration Number: NCT04800393

Locations: 🇷🇺
Moscow Scientific Clinical Center, Moscow, Russian Federation

Relationship Between Bispectral Index, EEG Features, and Propofol Effect-site Concentration in Young and Elderly Patients.

Completed

Conditions: Electroencephalography
Propofol
Aging
Depth of Anesthesia

Interventions: Drug: Propofol

First Posted Date: 2021-03-01

Last Posted Date: 2022-03-16

Lead Sponsor: Pontificia Universidad Catolica de Chile

Target Recruit Count: 30

Registration Number: NCT04774120

Locations: 🇨🇱
Division de Anestesia - Pontificia Universidad Catolica de Chile, Santiago, Metropolitana, Chile

PROUD Study - Preventing Opioid Use Disorders

First Posted Date: 2021-02-23

Last Posted Date: 2023-06-22

Lead Sponsor: Emory University

Target Recruit Count: 57

Registration Number: NCT04766996

Locations: 🇺🇸
Emory University Orthopaedic and Spine Hospital, Atlanta, Georgia, United States

Anesthesia on Gut Microbiota and Metabolomics

Not Applicable

Conditions: Hepatic Tumor Resection

Interventions: Drug: Propofol
Drug: Desflurane

First Posted Date: 2021-02-23

Last Posted Date: 2022-03-23

Lead Sponsor: National Taiwan University Hospital

Target Recruit Count: 60

Registration Number: NCT04767503

Locations: 🇨🇳
Department of Anesthesiology, Taipei, Taiwan

The Effect of Anesthesia on Cerebral Oxygenation

Completed

Conditions: One-Lung Ventilation
Thoracic Surgery
Postoperative Cognitive Complications

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2021-02-18

Last Posted Date: 2021-02-18

Lead Sponsor: Karadeniz Technical University

Target Recruit Count: 30

Registration Number: NCT04760262

Locations: 🇹🇷
Karadeniz Technical University, Trabzon, Turkey

Comparison of TIVA by Closed Loop Anaesthesia Delivery System Versus Target Controlled Infusion Device

Not Applicable

Recruiting

Conditions: Anesthesia

Interventions: Drug: Propofol

First Posted Date: 2021-02-01

Last Posted Date: 2024-01-23

Lead Sponsor: Sir Ganga Ram Hospital

Target Recruit Count: 160

Registration Number: NCT04731480

Locations: 🇮🇳
Sir Ganga Ram Hospital, New Delhi, Delhi, India
🇮🇳
Nitin Sethi, New Delhi, Delhi, India

The Effect of BIS-guided Propofol Induction on Hemodynamic Response in Patients With Cardiac Risk.

Not Applicable

Conditions: Anesthesia, General

Interventions: Drug: Propofol
Device: Bispectral Index Monitor

First Posted Date: 2021-01-28

Last Posted Date: 2021-02-03

Lead Sponsor: Istanbul University - Cerrahpasa (IUC)

Target Recruit Count: 60

Registration Number: NCT04729465

Efficacy and Safety of Remimazolam Tosylate for Sedation in Gastroscopy

Not Applicable

Recruiting

Conditions: Sedation Complication
Hypoxia
Propofol Adverse Reaction
Gastric Cancer

Interventions: Drug: Remimazolam tosylate
Drug: Propofol

First Posted Date: 2021-01-27

Last Posted Date: 2022-10-12

Lead Sponsor: RenJi Hospital

Target Recruit Count: 1800

Registration Number: NCT04727034

Locations: 🇨🇳
Shanghai East Hospital, Shanghai, Shanghai, China, China
🇨🇳
Renji Hospital, Shanghai, Shanghai, China, China
🇨🇳
Affiliated Hospital of Jiaxing University, Jiaxing, China

and more 2 locations