Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

The Effects of Dexmedetomidine on Early Stage Renal Functions in Pediatric Patients

Phase 4

Completed

Conditions: Renal Function Disorder
Hemodynamic Instability

Interventions: Drug: Ketamine
Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2013-09-23

Last Posted Date: 2013-09-23

Lead Sponsor: TC Erciyes University

Target Recruit Count: 60

Registration Number: NCT01948336

Remifentanil Use in Pediatric Rigid Bronchoscopy

Phase 4

Completed

Conditions: Pediatric Rigid Bronchoscopy

Interventions: Drug: Propofol
Drug: Ketamine
Drug: Remifentanil

First Posted Date: 2013-09-20

Last Posted Date: 2013-09-20

Lead Sponsor: Bezmialem Vakif University

Target Recruit Count: 40

Registration Number: NCT01947114

Locations: 🇹🇷
Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey

Propofol TCI Administered by Gastroenterologists During Endoscopy: a Randomized Double Blind Controlled Study

Phase 4

Completed

Conditions: Propofol
Target Controlled Infusion
Moderate Sedation
Gastrointestinal Endoscopy

Interventions: Drug: Propofol
Drug: Midazolam
Device: Target Controlled Infusion

First Posted Date: 2013-09-13

Last Posted Date: 2013-09-13

Lead Sponsor: Ospedale San Raffaele

Target Recruit Count: 140

Registration Number: NCT01941888

Locations: 🇮🇹
San Raffaele Hospital, Milan, Italy

Remimazolam Phase II Cardiac Anesthesia Study

Phase 2

Completed

Conditions: General Anesthesia

Interventions: Drug: Propofol
Drug: Remimazolam
Drug: Remifentanil
Drug: Sevoflurane
Drug: Fentanyl
Drug: Rocuronium

First Posted Date: 2013-09-10

Last Posted Date: 2020-01-18

Lead Sponsor: Paion UK Ltd.

Target Recruit Count: 90

Registration Number: NCT01937767

Locations: 🇩🇪
Herzzentrum Leipzig GmbH, Leipzig, Germany

Satisfaction With Nurse Administered Propofol Sedation vs. Midazolam With Fentanyl Sedation for Endoscopy

Phase 4

Completed

Conditions: Inflammatory Bowel Disease
Endoscopy
Sedation

Interventions: Drug: Propofol
Drug: Midazolam
Drug: Fentanyl

First Posted Date: 2013-09-04

Last Posted Date: 2015-09-29

Lead Sponsor: Copenhagen University Hospital at Herlev

Target Recruit Count: 130

Registration Number: NCT01934088

Locations: 🇩🇰
Endoscopy, Gastrounit, Herlev Hospital, Herlev, Region H, Denmark

Comparing Ketamine and Propofol Anesthesia for Electroconvulsive Therapy

Phase 4

Completed

Conditions: Treatment Resistant Depression

Interventions: Drug: Propofol
Drug: Ketamine

First Posted Date: 2013-09-04

Last Posted Date: 2017-09-13

Lead Sponsor: University of Saskatchewan

Target Recruit Count: 27

Registration Number: NCT01935115

Locations: 🇨🇦
Royal University Hospital, Saskatoon, Saskatchewan, Canada

The Medasense Study

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Propofol
Drug: Remifentanil

First Posted Date: 2013-07-30

Last Posted Date: 2015-04-06

Lead Sponsor: Leiden University Medical Center

Target Recruit Count: 96

Registration Number: NCT01912118

Locations: 🇳🇱
Leiden University Medical Center, Leiden, Netherlands

Comparison Between Continuous Infusion and Intermittent Bolus Injection of Propofol for Deep Sedation During ERCP

Not Applicable

Conditions: Biliary Tract Diseases
Pancreatic Diseases

Interventions: Procedure: Intermittent bolus injection of propofol
Procedure: Continuous infusion of propofol
Drug: Propofol
Drug: Midazolam

First Posted Date: 2013-07-17

Last Posted Date: 2013-07-17

Lead Sponsor: Hanyang University

Target Recruit Count: 210

Registration Number: NCT01900938

Locations: 🇰🇷
Hanyang University Guri Hospital, Guri, Gyeonggi, Korea, Republic of

A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial

Phase 4

Completed

Conditions: Obstructive Sleep Apnea

Interventions: Drug: propofol-remifentanil
Drug: Dexmedetomidine-remifentanil
Drug: Propofol

First Posted Date: 2013-07-10

Last Posted Date: 2016-08-17

Lead Sponsor: Yonsei University

Target Recruit Count: 60

Registration Number: NCT01895348

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of

The Neural Mechanisms of Anesthesia and Human Consciousness

Phase 4

Completed

Conditions: Consciousness, Level Altered

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2013-06-28

Last Posted Date: 2016-01-11

Lead Sponsor: University of Turku

Target Recruit Count: 47

Registration Number: NCT01889004

Locations: 🇫🇮
Turku PET Centre, Turku, Finland

Drug Development Updates

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