Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

The Efficacy And Cognitive Impairment Of Modified Electroconvulsive Therapy

Not Applicable

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Etomidate
Drug: Propofol
Device: The right temporal MECT
Device: Bilateral temporal MECT
Device: Bilateral frontal MECT

First Posted Date: 2014-02-19

Last Posted Date: 2018-04-23

Lead Sponsor: Shanghai Mental Health Center

Target Recruit Count: 280

Registration Number: NCT02066077

Locations: 🇨🇳
Shanghai Mental Health Center, Shanghai, China

Propofol Administered by Gastroenterologists by Target Controlled Infusion Pump During Endoscopy

Phase 4

Completed

Conditions: Endoscopy
Sedation

Interventions: Drug: Propofol
Drug: Midazolam

First Posted Date: 2014-02-13

Last Posted Date: 2014-09-08

Lead Sponsor: Università Vita-Salute San Raffaele

Target Recruit Count: 140

Registration Number: NCT02062177

Locations: 🇮🇹
San Raffaele Hospital, Milan, Italy

Anesthesia in Patients With Mitochondrial Disease

Not Applicable

Terminated

Conditions: Mitochondrial Diseases

Interventions: Drug: Sevoflurane
Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2014-02-04

Last Posted Date: 2024-08-28

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 19

Registration Number: NCT02053766

Locations: 🇺🇸
University of Texas Health Science Center at Houston, Houston, Texas, United States

RCT of Efficacy and Safety of Sedation Compared to General Anesthesia for ERCP

Not Applicable

Terminated

Conditions: Anesthesia
Safety
Efficacy
ERCP

Interventions: Other: General anesthesia
Drug: Propofol

First Posted Date: 2014-01-28

Last Posted Date: 2023-02-15

Lead Sponsor: Erasme University Hospital

Target Recruit Count: 120

Registration Number: NCT02046590

Locations: 🇧🇪
Gastroenterology Department Erasme Hospital, Brussels, Belgium

Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation

Phase 1

Terminated

Conditions: Premature Birth of Newborn
Anesthesia Intubation Complication
Other Preterm Infants
Propofol Overdose

Interventions: Drug: Propofol

First Posted Date: 2014-01-20

Last Posted Date: 2018-02-01

Lead Sponsor: Erasmus Medical Center

Target Recruit Count: 91

Registration Number: NCT02040909

Locations: 🇳🇱
Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands
🇳🇱
VU Medical Center, Amsterdam, Netherlands
🇳🇱
Maxima Medisch Centrum, Veldhoven, Netherlands

Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies

Not Applicable

Completed

Conditions: Eosinophilic Esophagitis

Interventions: Drug: Intubated with Sevoflurane (IS)
Drug: Intubated with Propofol (IP)
Drug: Zofran - no intubation
Drug: Propofol

First Posted Date: 2014-01-17

Last Posted Date: 2020-09-24

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 179

Registration Number: NCT02038894

Locations: 🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery

Not Applicable

Completed

Conditions: Renal Failure

Interventions: Device: B-Braun, Perifix® ONE Paed, Germany
Drug: Pethidine
Drug: Fentanyl
Drug: Propofol
Drug: Bupivacaine

First Posted Date: 2014-01-16

Last Posted Date: 2014-10-06

Lead Sponsor: Cairo University

Target Recruit Count: 60

Registration Number: NCT02037802

Locations: 🇪🇬
Faculty of medicine, Cairo University, Cairo, Egypt

Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children

Phase 4

Conditions: Congenital Hydronephrosis
Congenital Choledochal Cyst
Fracture

Interventions: Drug: etomidate
Drug: midazolam
Drug: propofol

First Posted Date: 2013-12-17

Last Posted Date: 2013-12-17

Lead Sponsor: Du yi

Target Recruit Count: 30

Registration Number: NCT02013986

Locations: 🇨🇳
department of anesthesia of Xinhua Hospital, Shanghai, Shanghai, China

Anesthesia and Circulating Tumor Cells in Breast Cancer

Phase 4

Completed

Conditions: Female Breast Carcinoma

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2013-12-09

Last Posted Date: 2020-04-14

Lead Sponsor: University of Zurich

Target Recruit Count: 221

Registration Number: NCT02005770

Locations: 🇨🇭
Institute of Physicians for Anesthesia and Intensive Care Klinik Hirslanden, Zurich, Switzerland
🇨🇭
University Hospital Zurich, Institute of Anesthesiology, Zurich, ZH, Switzerland

The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia

Not Applicable

Withdrawn

Conditions: Optic Nerve Sheath

Interventions: Drug: Propofol
Drug: Desflurane

First Posted Date: 2013-12-06

Last Posted Date: 2014-07-15

Lead Sponsor: Yonsei University

Registration Number: NCT02003768

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