Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Inflammation After One Lung Ventilation

Phase 1

Completed

Conditions: Inflammation

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2014-07-11

Last Posted Date: 2014-07-11

Lead Sponsor: University Medical Centre Ljubljana

Target Recruit Count: 40

Registration Number: NCT02188407

Locations: 🇸🇮
UMCLjubljana, CD of Anaesthesiology and Intensive Therapy, Ljubljana, Slovenia

Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation

Phase 4

Completed

Conditions: Induction of Anaesthesia

Interventions: Drug: etomidate-propofol
Drug: etomidate
Drug: propofol

First Posted Date: 2014-07-10

Last Posted Date: 2014-08-13

Lead Sponsor: T.C. ORDU ÜNİVERSİTESİ

Target Recruit Count: 90

Registration Number: NCT02186990

Locations: 🇹🇷
Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital, Altınordu, Ordu, Turkey

Bispectral Index Guiding Etomidate Used in Children Aged 3 to 10 for Clinical Anesthesia Induction

Phase 4

Conditions: Bispectral Index
Pediatric
Etomidate
Induction

Interventions: Drug: etomidate
Drug: propofol
Drug: sevoflurane

First Posted Date: 2014-07-08

Last Posted Date: 2014-07-08

Lead Sponsor: Henan Provincial People's Hospital

Target Recruit Count: 120

Registration Number: NCT02182648

Moderate Sedation for Elective Upper Endoscopy With Balanced Propofol Versus Propofol Alone: a Randomized Clinical Trial

Not Applicable

Completed

Conditions: EGD Procedure

Interventions: Drug: Midazolam + propofol
Drug: propofol

First Posted Date: 2014-06-25

Last Posted Date: 2017-01-25

Lead Sponsor: Yonsei University

Target Recruit Count: 22

Registration Number: NCT02174588

Locations: 🇰🇷
Yonsei university College of Medicine, Seoul, Korea, Republic of

The Application of Target Controlled Infusion of Etomidate Combined With Propofol in the Maintenance of Anesthesia During Brain Surgeries

Phase 4

Conditions: Target Controlled Infusion
General Anesthesia

Interventions: Drug: etomidate
Drug: propofol

First Posted Date: 2014-06-25

Last Posted Date: 2014-06-25

Lead Sponsor: Henan Provincial People's Hospital

Target Recruit Count: 120

Registration Number: NCT02174120

Inflammatory Response Secondary Using Intravenous Anesthesia Versus Inhalation Anesthesia With Halogenated Agents

Phase 4

Completed

Conditions: Pulmonary Resection

Interventions: Drug: propofol
Drug: Sevoflurane

First Posted Date: 2014-06-20

Last Posted Date: 2016-04-06

Lead Sponsor: Hospital General Universitario Gregorio Marañon

Target Recruit Count: 180

Registration Number: NCT02168751

Locations: 🇪🇸
Anesthesiology Department Hospital GU Gregorio Mrañón, Madrid, Spain

The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide

Phase 4

Completed

Conditions: Prostate Cancer

Interventions: Drug: Desflurane
Drug: propofol

First Posted Date: 2014-05-29

Last Posted Date: 2015-07-29

Lead Sponsor: Yonsei University

Target Recruit Count: 50

Registration Number: NCT02149628

Locations: 🇰🇷
Yonsei University, Gangnam Severance Hospital, Seoul, Korea, Republic of

A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients

Phase 4

Conditions: Hysteroscopy
Hemodynamics
Sedation

Interventions: Drug: Etomidate
Drug: Propofol
Drug: Remifentanil
Drug: Anesthesia induction

First Posted Date: 2014-05-28

Last Posted Date: 2014-05-28

Lead Sponsor: Shaanxi Provincial People's Hospital

Target Recruit Count: 120

Registration Number: NCT02147678

Postoperative Sleep Quality of Patients Anesthesia With Propofol or Sevoflurane Undergoing Thyroidectomy

Phase 4

Completed

Conditions: Postoperative Sleep Quality

Interventions: Drug: propofol
Drug: sevoflurane

First Posted Date: 2014-05-26

Last Posted Date: 2016-01-29

Lead Sponsor: China Medical University, China

Target Recruit Count: 124

Registration Number: NCT02146976

Locations: 🇨🇳
the First Hospital of China Medical University, Shenyang, Liaoning, China

Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery

Phase 4

Completed

Conditions: Valvular Heart Disease
Aortic Disease

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2014-05-13

Last Posted Date: 2018-01-18

Lead Sponsor: Konkuk University Medical Center

Target Recruit Count: 2

Registration Number: NCT02136979

Locations: 🇰🇷
Konkuk University Medical Center, Seoul, Korea, Republic of

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