Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Comparison of Propofol/Alfentanil With Propofol/Ketamine

Not Applicable

Conditions: Lung Disease

Interventions: Drug: Propofol
Drug: Alfentanil
Drug: Ketamine

First Posted Date: 2013-12-04

Last Posted Date: 2013-12-04

Lead Sponsor: Rabin Medical Center

Target Recruit Count: 80

Registration Number: NCT02000206

Locations: 🇮🇱
Pulmonary Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel

Prothrombotic Factors and Anaesthesia in Prostate Cancer

Not Applicable

Completed

Conditions: Surgery
Prostatic Cancer

Interventions: Drug: Midazolam
Drug: Propofol
Drug: Fentanyl
Drug: remifentanyl
Drug: Sevoflurane

First Posted Date: 2013-12-02

Last Posted Date: 2014-11-06

Lead Sponsor: Regina Elena Cancer Institute

Target Recruit Count: 200

Registration Number: NCT01998685

Locations: 🇮🇹
Department of Anaesthesiology, Regina Elena, National Cancer Institute, Roma, Italy

Sevoflurane and Propofol Anesthesia on Postoperative Delirium

Phase 4

Conditions: General Anesthesia
Geriatric Patient

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2013-11-26

Last Posted Date: 2013-11-26

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 500

Registration Number: NCT01995214

Locations: 🇨🇳
Tongji Hospital, Wuhan, Hubei, China

Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery

Phase 4

Conditions: Patients Undergoing Elective Craniotomy

Interventions: Drug: Propofol
Drug: Desflurane

First Posted Date: 2013-11-15

Last Posted Date: 2013-11-15

Lead Sponsor: Tokyo Women's Medical University

Target Recruit Count: 60

Registration Number: NCT01985854

Locations: 🇯🇵
Tokyo Women's Medical University Hospital, Tokyo, Japan

Effect of Intravenous Dexmedetomidine on Analgesic Duration of Infraclavicular Block

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Drug: Propofol
Drug: Dexmedetomidine
Procedure: Infraclavicular block

First Posted Date: 2013-11-11

Last Posted Date: 2019-05-29

Lead Sponsor: Lawson Health Research Institute

Target Recruit Count: 100

Registration Number: NCT01981369

Locations: 🇨🇦
Saint Joseph's Health Care London, London, Ontario, Canada

Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative Medication

Phase 4

Completed

Conditions: Elective Orthopedic Surgery

Interventions: Drug: Propofol
Drug: Midazolam
Drug: Saline

First Posted Date: 2013-11-06

Last Posted Date: 2016-03-14

Lead Sponsor: Cedars-Sinai Medical Center

Target Recruit Count: 139

Registration Number: NCT01976845

Locations: 🇺🇸
Cedars Sinai Medical center, Los Angeles, California, United States

Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia

Phase 4

Completed

Conditions: Breast Neoplasms
Colonic Neoplasms
Rectal Neoplasms

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2013-11-03

Last Posted Date: 2022-12-14

Lead Sponsor: Uppsala University

Target Recruit Count: 5774

Registration Number: NCT01975064

Locations: 🇵🇱
Wroclaw Medical University, Wroclaw, Poland
🇨🇳
Fourth Military Medical University Hospital, Xijing, China
🇸🇪
Skane University Hospital, Lund, Lund, Sweden

and more 12 locations