Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

The Optimal Effect Site Concentration of Propofol for Conscious Sedation in Elderly Male Patients Undergoing Urologic Surgery Under Spinal Anesthesia With or Without Intrathecal Fentanyl

Not Applicable

Completed

Conditions: Conscious Sedation Under Spinal Anesthesia

Interventions: Drug: propofol

First Posted Date: 2010-11-02

Last Posted Date: 2013-03-06

Lead Sponsor: Yonsei University

Target Recruit Count: 43

Registration Number: NCT01232270

Locations: 🇰🇷
Severance Hospital, Seoul, Korea, Republic of

Safety and Efficacy of Propofol Only Sedation in Oral and Maxillofacial Surgery

Phase 4

Conditions: Procedural Sedation
Propofol

Interventions: Drug: Propofol

First Posted Date: 2010-10-25

Last Posted Date: 2010-10-25

Lead Sponsor: Atlantic Center for Oral and Maxillofacial Surgery

Target Recruit Count: 169

Registration Number: NCT01227174

Locations: 🇨🇦
Atlantic Centre for Oral and Maxillofacial Surgery 1278 Tower Rd., Halifax, Nova Scotia, Canada

Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry

Completed

Conditions: Blindness

Interventions: Drug: Sevoflurane
Drug: propofol

First Posted Date: 2010-10-13

Last Posted Date: 2015-04-24

Lead Sponsor: Rutgers, The State University of New Jersey

Target Recruit Count: 35

Registration Number: NCT01219569

Locations: 🇺🇸
University Hospital, Newark, New Jersey, United States

A Pilot Study to Investigate Plasma Bupivacaine Concentrations in Children Receiving Total Intravenous Anaesthesia and Caudal Analgesia

Phase 1

Completed

Conditions: Anesthesia

Interventions: Drug: sevoflurane
Drug: propofol

First Posted Date: 2010-10-07

Last Posted Date: 2017-06-26

Lead Sponsor: University of British Columbia

Target Recruit Count: 30

Registration Number: NCT01216007

Locations: 🇨🇦
BC Children's Hospital, Department of Anesthesia, Vancouver, British Columbia, Canada

The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation

Not Applicable

Completed

Conditions: Intracranial Neurosurgery

Interventions: Drug: propofol
Drug: dexmedetomidine

First Posted Date: 2010-09-13

Last Posted Date: 2016-12-14

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 44

Registration Number: NCT01200433

Locations: 🇺🇸
Cleveland Clinic Foundation, Cleveland, Ohio, United States

Long-term Outcome of General Anesthesia on Dysgnosia

Phase 4

Conditions: Delirium,
Dementia,
Amnestic,
Cognitive Disorders

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2010-08-19

Last Posted Date: 2014-01-14

Lead Sponsor: Nanjing Medical University

Target Recruit Count: 10000

Registration Number: NCT01184638

Locations: 🇨🇳
Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, China

Comparing Safety and Efficacy of Dexmedetomidine and Propofol

Phase 3

Terminated

Conditions: Safety and Efficacy of Sedation Medications

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2010-06-29

Last Posted Date: 2019-05-21

Lead Sponsor: Boston Children's Hospital

Target Recruit Count: 15

Registration Number: NCT01152021

Locations: 🇺🇸
Children's Hospital Boston, Boston, Massachusetts, United States

Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction

Phase 4

Completed

Conditions: Anesthesia Intubation Complication

Interventions: Drug: propofol

First Posted Date: 2010-06-28

Last Posted Date: 2021-02-08

Lead Sponsor: University of Virginia

Target Recruit Count: 106

Registration Number: NCT01150838

Locations: 🇺🇸
University of Virginia Health System, Charlottesville, Virginia, United States

Propofol Versus Midazolam for Upper Endoscopy in Cirrhotic Patients

Not Applicable

Completed

Conditions: Cirrhosis

Interventions: Drug: propofol
Drug: Midazolam

First Posted Date: 2010-06-10

Last Posted Date: 2010-06-10

Lead Sponsor: Ziv Hospital

Target Recruit Count: 60

Registration Number: NCT01141036

Locations: 🇮🇱
Ziv medical center liver unit, Safed, Israel, Israel

A Comparative Study of Depth of Anesthesia Monitored by Bispectral Index (BIS) Values

Phase 2

Completed

Conditions: Anesthetics

Interventions: Drug: thiopental,propofol
Drug: propofol

First Posted Date: 2010-06-09

Last Posted Date: 2010-06-09

Lead Sponsor: Shiraz University of Medical Sciences

Target Recruit Count: 82

Registration Number: NCT01140100

Locations: 🇮🇷
Shiraz University of Medical Sciences, Shiraz, Fars, Iran, Islamic Republic of

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