Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Comparison of the Protective Effect of Desflurane and Propofol in Patients With Renal Transplantation

Phase 4

Completed

Conditions: Healthy
End Stage Renal Disease

Interventions: Drug: Desflurane
Drug: Propofol

First Posted Date: 2010-05-27

Last Posted Date: 2014-03-05

Lead Sponsor: Yonsei University

Target Recruit Count: 99

Registration Number: NCT01132157

Locations: 🇰🇷
Severance hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

Combined Ketamine/Propofol for Emergency Department Procedural Sedation

Not Applicable

Terminated

Conditions: Procedural Sedation and Analgesia

Interventions: Drug: Placebo
Drug: Ketamine
Drug: Fentanyl
Drug: Propofol

First Posted Date: 2010-05-20

Last Posted Date: 2023-04-24

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 107

Registration Number: NCT01126957

Locations: 🇺🇸
University of Missouri - Columbia dept. of Emergency Medicine, Columbia, Missouri, United States

Postoperative Fatigue and Nausea Related to Choice of Anaesthetic Regimens

Phase 4

Completed

Conditions: Nausea
Fatigue

Interventions: Drug: Desflurane
Drug: Propofol

First Posted Date: 2010-05-19

Last Posted Date: 2014-11-19

Lead Sponsor: Sykehuset Telemark

Target Recruit Count: 130

Registration Number: NCT01125982

Locations: 🇳🇴
Telemark Hospital, Skien, Telemark, Norway

Propofol and Perioperative Inflammation

Phase 4

Completed

Conditions: Inflammation

Interventions: Drug: Saline
Drug: Intralipid 10%
Drug: propofol

First Posted Date: 2010-05-04

Last Posted Date: 2010-05-19

Lead Sponsor: University Hospital, Geneva

Target Recruit Count: 79

Registration Number: NCT01115179

Locations: 🇨🇭
Service of Anesthesiology; Geneva University Hospital, Geneva, Switzerland

Dose Titration of Propofol for Tracheal Intubation in Children With Sevoflurane Inhalation Induction

Not Applicable

Completed

Conditions: Pediatric Urinary Disorders

Interventions: Drug: propofol

First Posted Date: 2010-03-10

Last Posted Date: 2014-02-19

Lead Sponsor: Yonsei University

Target Recruit Count: 50

Registration Number: NCT01084031

Patient-controlled Sedation With Propofol and Remifentanyl for Endoscopic Retrograde Cholangiopancreatography (ERCP)

Phase 4

Completed

Conditions: Endoscopic Retrograde Cholangiopancreatography

Interventions: Device: infusion pump
Device: infusion pump for patient-controlled sedation
Drug: propofol
Drug: fentanyl
Drug: sedative mixture
Drug: remifentanil hydrochlorid

First Posted Date: 2010-03-03

Last Posted Date: 2020-12-22

Lead Sponsor: Helsinki University Central Hospital

Target Recruit Count: 80

Registration Number: NCT01079312

Locations: 🇫🇮
Helsinki University Central Hospital,Meilahti hospital,Endoscopy unit, Helsinki, Uusimaa, Finland

A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters

Not Applicable

Completed

Conditions: Blood Pressure

Interventions: Drug: Propofol
Drug: Ketamine

First Posted Date: 2010-02-09

Last Posted Date: 2013-05-03

Lead Sponsor: Mayo Clinic

Target Recruit Count: 85

Registration Number: NCT01065350

Locations: 🇺🇸
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States

Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)

Phase 4

Terminated

Conditions: Critical Illness
Mechanical Ventilation

Interventions: Drug: Dexmedetomidine
Drug: Propofol
Drug: Fentanyl
Drug: Midazolam
Behavioral: Physical and Occupational Therapy

First Posted Date: 2010-02-01

Last Posted Date: 2018-07-03

Lead Sponsor: University of Chicago

Target Recruit Count: 41

Registration Number: NCT01059929

Locations: 🇺🇸
The University of Chicago Medical Center, Chicago, Illinois, United States

Propofol Versus Midazolam With Fentanyl for EGD Endomicroscopy

Not Applicable

Completed

Conditions: Gastritis
Functional Dyspepsia

Interventions: Drug: midazolam with fentanyl
Drug: propofol

First Posted Date: 2010-01-22

Last Posted Date: 2011-06-14

Lead Sponsor: Shandong University

Target Recruit Count: 104

Registration Number: NCT01053871

Locations: 🇨🇳
Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, China

Sedation in Patients at Risk for Upper Airway Collapse

Not Applicable

Completed

Conditions: Obstructive Sleep Apnea

Interventions: Drug: Propofol
Drug: Dexmedetomidine

First Posted Date: 2010-01-08

Last Posted Date: 2015-04-27

Lead Sponsor: University of Rochester

Target Recruit Count: 15

Registration Number: NCT01045122

Locations: 🇺🇸
University of Rochester, Rochester, New York, United States

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2024. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy