Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Study of Efficacy, Pharmacokinetics and Safety of Continuous Intravenous Infusion of Org 9426 (Study P05977)

Phase 3

Completed

Conditions: Anesthesia

Interventions: Drug: Rocuronium bromide
Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2009-10-02

Last Posted Date: 2015-05-12

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 38

Registration Number: NCT00988520

Study of Efficacy, Pharmacokinetics, and Safety of Bolus Maintenance Doses of Org 9426 (Study P05976)(COMPLETED)

Phase 3

Completed

Conditions: Muscle Relaxation

Interventions: Drug: Rocuronium bromide (Org 9426)
Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2009-09-25

Last Posted Date: 2015-05-12

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 40

Registration Number: NCT00984633

Pain After Laparoscopic Cholecystectomy

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Drug: Isoflurane
Drug: Desflurane
Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2009-09-24

Last Posted Date: 2019-02-01

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 80

Registration Number: NCT00983918

Locations: 🇺🇸
Ben Taub General Hospital, Houston, Texas, United States

Onset Time of Thiopental Versus Propofol in the Elderly

Phase 4

Completed

Conditions: Induction of Anaesthesia
Age

Interventions: Drug: Thiopental
Drug: Propofol

First Posted Date: 2009-08-25

Last Posted Date: 2010-03-09

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 78

Registration Number: NCT00965107

Locations: 🇩🇰
Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
🇩🇰
Department of Anesthesia, Juliane Marie Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark