Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
Related News

Procedural Sedation Using Propofol Versus Midazolam/Ketamine in the Adult Emergency Department

Phase 4
Completed
Conditions
Procedural Sedation
Interventions
Drug: Ketamine/Midazolam
Drug: Propofol
First Posted Date
2008-11-04
Last Posted Date
2010-08-03
Lead Sponsor
Tel-Aviv Sourasky Medical Center
Target Recruit Count
60
Registration Number
NCT00784498
Locations
🇮🇱

Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Use of Closed-loop Anesthesia in Pediatric Patients

Phase 4
Terminated
Conditions
Anesthesia
Interventions
Drug: Propofol
Drug: Remifentanil
First Posted Date
2008-10-23
Last Posted Date
2016-09-23
Lead Sponsor
Hopital Foch
Target Recruit Count
45
Registration Number
NCT00778505
Locations
🇫🇷

Hôpital Foch, Suresnes, France

🇫🇷

Hôpital Necker Enfants, Paris, France

Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF

Phase 3
Completed
Conditions
Respiratory Insufficiency
Interventions
Drug: Placebo
Drug: Propofol
First Posted Date
2008-08-26
Last Posted Date
2011-08-26
Lead Sponsor
University Hospital, Bordeaux
Target Recruit Count
46
Registration Number
NCT00741949
Locations
🇫🇷

University Hospital Bordeaux, Groupe Hospitalier Pellegrin, Bordeaux cedex, France

🇫🇷

Centre hospitalier Libourne, Libourne, France

Propofol Cardioprotection for Type II Diabetics

Phase 2
Completed
Conditions
Myocardial Injury
Interventions
Drug: Propofol
First Posted Date
2008-08-14
Last Posted Date
2012-07-13
Lead Sponsor
University of British Columbia
Target Recruit Count
137
Registration Number
NCT00734383
Locations
🇨🇦

UBC Dept of Anesthesiology, Pharmacology & Therapeutics, Vancouver Acute Hospital, Vancouver, British Columbia, Canada

Evaluation of Different Anesthesia for Uterine Curettage

First Posted Date
2008-08-13
Last Posted Date
2009-03-31
Lead Sponsor
Nanjing Medical University
Target Recruit Count
150
Registration Number
NCT00733564
Locations
🇨🇳

Nanjing Maternal and Child Health Care Hospital, Nanjing, Jiangsu, China

Propofol Versus Volatile Anesthesia in Post Operative Pain Management

Not Applicable
Terminated
Conditions
Varicose Vein
Postoperative Pain
Interventions
Drug: propofol
Drug: sevoflurane
First Posted Date
2008-07-10
Last Posted Date
2016-07-20
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
90
Registration Number
NCT00712517
Locations
🇦🇹

Olga Plattner , MD, Vienna, Austria

Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

First Posted Date
2008-06-27
Last Posted Date
2009-02-10
Lead Sponsor
Medical University Innsbruck
Target Recruit Count
60
Registration Number
NCT00706277
Locations
🇦🇹

TILAK Hospitals, Innsbruck, Austria

Use of a Modified Propofol Emulsion in Adults

Phase 3
Completed
Conditions
Anesthesia
Interventions
Drug: Propofol 1%
Drug: Propofol
First Posted Date
2008-06-04
Last Posted Date
2012-01-05
Lead Sponsor
B. Braun Melsungen AG
Target Recruit Count
100
Registration Number
NCT00690495
Locations
🇩🇪

Klinik für Anästhesie und operative Intensivmedizin, Klinikum Leverkusen gGmbH, Leverkusen, Nordrhein-Westfalen, Germany

Evaluation of a Closed-Loop Control System for Administering Patient-Specific Anesthesia

Phase 1
Completed
Conditions
Anesthesia, General
First Posted Date
2008-05-26
Last Posted Date
2011-11-24
Lead Sponsor
Stanford University
Target Recruit Count
35
Registration Number
NCT00683956
Locations
🇺🇸

Stanford University School of Medicine, Stanford, California, United States

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

First Posted Date
2008-05-21
Last Posted Date
2012-01-06
Lead Sponsor
University of Parma
Target Recruit Count
22
Registration Number
NCT00681174
Locations
🇮🇹

University Hospital / Azienda Ospedaliero-Universitaria, Parma, PR, Italy

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