Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

EEG and Auditory Evoked Potentials During Local Anesthesia

Phase 4

Conditions: Healthy

First Posted Date: 2006-12-08

Last Posted Date: 2006-12-08

Lead Sponsor: Technical University of Munich

Target Recruit Count: 15

Registration Number: NCT00408941

Locations: 🇩🇪
Technische Universität München, Klinikum rechts der Isar, Department of Anesthesiology, Munich, Bavaria, Germany

Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane

Not Applicable

Completed

Conditions: Coronary Artery Bypass
Delirium
Dementia
Amnesia
Cognition Disorders
Morbidity

First Posted Date: 2006-11-17

Last Posted Date: 2010-06-29

Lead Sponsor: University of Melbourne

Target Recruit Count: 182

Registration Number: NCT00400790

Locations: 🇦🇺
Royal Melbourne Hospital, Melbourne, Victoria, Australia

Population PK/PD of Propofol in the Morbidly Obese Patient

Phase 4

Completed

Conditions: Morbid Obesity

Interventions: Drug: Diprivan

First Posted Date: 2006-11-03

Last Posted Date: 2010-10-22

Lead Sponsor: St. Antonius Hospital

Target Recruit Count: 20

Registration Number: NCT00395681

Locations: 🇳🇱
st. Antonius hospital, Nieuwegein, Netherlands

The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats

Not Applicable

Completed

Conditions: Myocardial Repolarization

First Posted Date: 2006-08-01

Last Posted Date: 2009-08-18

Lead Sponsor: University of British Columbia

Target Recruit Count: 60

Registration Number: NCT00358618

Locations: 🇨🇦
British Columbia Children's Hospital, Anesthesia Dept., Vancouver, British Columbia, Canada

Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)

Phase 3

Completed

Conditions: End-stage Chronic Renal Disease
Severe Acute Kidney Failure
Renal Transplantation

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2006-06-15

Last Posted Date: 2010-06-23

Lead Sponsor: University Hospital, Bordeaux

Target Recruit Count: 120

Registration Number: NCT00337051

Locations: 🇫🇷
Département d'anesthésie réanimation 1 - Hôpital Pellegrin - CHU de Bordeaux, Bordeaux, France

Anaesthesia With Propofol Versus Midazolam : Effect on Oxidative Stress in the Brain of Head Trauma Patients

Phase 3

Terminated

Conditions: Traumatic Brain Injury

Interventions: Drug: Midazolam
Drug: Propofol

First Posted Date: 2006-06-14

Last Posted Date: 2012-03-02

Lead Sponsor: Rennes University Hospital

Target Recruit Count: 30

Registration Number: NCT00336882

Locations: 🇫🇷
Réanimation Chirurgicale - Hôpital de Pontchaillou, Rennes, France

Effect of Dexmedetomidine Upon Sleep Postoperatively

Phase 4

Withdrawn

Conditions: Sleep

First Posted Date: 2006-06-06

Last Posted Date: 2014-07-14

Lead Sponsor: Duke University

Registration Number: NCT00333632

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Effect Site Controlled, Reaction Time Safeguarded, Patient Maintained Sedation With Propofol in Healthy Volunteers

Phase 4

Completed

Conditions: Healthy

First Posted Date: 2006-05-03

Last Posted Date: 2012-02-07

Lead Sponsor: Sonia Allam

Target Recruit Count: 20

Registration Number: NCT00321360

Locations: 🇬🇧
Glasgow Dental Hospital, Glasgow, Strathclyde, United Kingdom

Post-Marketing Clinical Study to Assess Efficacy and Safety of Dexmedetomidine in Post-Operative Patients

Phase 4

Completed

Conditions: Conscious Sedation

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2006-04-27

Last Posted Date: 2017-03-20

Lead Sponsor: Hospira, now a wholly owned subsidiary of Pfizer

Target Recruit Count: 85

Registration Number: NCT00318955

Locations: 🇯🇵
Kinki University Hospital, Osaka-Sayama-Shi, Osaka, Japan
🇯🇵
Osaka University Hospital, Suita, Osaka, Japan
🇯🇵
Nippon Medical School Hospital, Bunkyo-ku, Tokyo, Japan

and more 10 locations

The Influence of Injection Rate on EEG Propofol Peak Effect as Measured by Bispectral Index

Not Applicable

Completed

Conditions: Elective Surgery
Healthy

First Posted Date: 2006-02-10

Last Posted Date: 2006-02-10

Lead Sponsor: Technical University of Munich

Target Recruit Count: 99

Registration Number: NCT00290108

Locations: 🇩🇪
Technische Universität München, Klinikum rechts der Isar, Department of Anesthesiology, Munich, Bavaria, Germany

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